Fluoroquinolones Damage Mitochondrial Lipids

Fluoroquinolones are Mito-Toxic

Many articles about how fluoroquinolones damage mitochondria and lead to mitochondrial dysfunction have been published.  In Science Translational Medicine, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells,” it is noted that bactericidal antibiotics, including ciprofloxacin, a fluoroquinolone, “damage mammalian tissues by triggering mitochondrial release of reactive oxygen species (ROS).”  Additionally, in Molecular Pharmacology, “Delayed Cytotocicity and Cleavage of Mitochondrial DNA in Ciprofloxacin Treated Mammalian Cells” it is noted that fluoroquinolones “cause a selective loss of mitochondrial DNA (mtDNA)” and “The loss in mtDNA was associated with a delayed loss in mitochondrial function.”  Even the FDA acknowledges that fluoroquinolones cause mitochondrial damage.  In their April 27, 2013 Pharmacovigilance Review, “Disabling Peripheral Neuropathy Associated with Systemic Fluoroquinolone Exposure,” the FDA notes that the mechanism for action through which fluoroquinolones induce peripheral neuropathy is mitochondrial toxicity. The report says:

“Ciprofloxacin has been found to affect mammalian topoisomerase II, especially in mitochondria. In vitro studies in drug-treated mammalian cells found that nalidixic acid and ciprofloxacin cause a loss of mitochondrial DNA (mtDNA), resulting in a decrease of mitochondrial respiration and an arrest in cell growth. Further analysis found protein-linked double-stranded DNA breaks in the mtDNA from ciprofloxacin-treated cells, suggesting that ciprofloxacin was targeting topoisomerase II activity in the mitochondria.”

Fluoroquinolones are very, very bad for mitochondria.  And, as the engines of our cells, healthy mitochondria are very necessary for healthy cells.  Mitochondrial dysfunction is connected with many chronic diseases, including autism, CFS/ME, fibromyalgia, Alzheimer’s Disease, Parkinson’s Disease, multiple sclerosis, etc.

Even though there is quite a bit of evidence that fluoroquinolones damage mitochondria, it is not generally acknowledged that fluoroquinolones are mito-toxic.  A petition has been filed with the FDA asking them to add a warning about mitochondrial toxicity to the label of fluoroquinolones.  If the FDA adds the information that is in their internal documents to the public warning label, it will become accepted and acknowledged that fluoroquinolones damage mitochondria, and that fact will be further reflected in research articles.  The ball has to start rolling somewhere.  I thank the researchers who have uncovered the mitochondrial toxicity of fluoroquinolones very much for their research that got the realization of the mito-toxicity of fluoroquinolones started.

Similarities between Fluoroquinolones and other Mito-Toxic Drugs

A drug that is acknowledged to be mito-toxic is adriamycin (doxorubicin).  In Toxicological Sciences, “Review: Mitochondria as a Target of Environmental Toxicants” it is noted that:

“One well-studied example is adriamycin (doxorubicin), a chemotherapeutic whose clinical use is limited by the fact that it also causes irreversible and cumulative cardiomyopathy (Wallace, 2007). It appears to act largely by poisoning mitochondria, both via redox cycling to generate ROS and by inhibiting ATP production via uncoupling of oxidative phosphorylation. Although its antineoplastic function is largely a result of DNA intercalation and topoisomerase II inhibition in the nucleus, a substantial amount reaches mitochondria, where it has a high binding affinity for cardiolipin, a lipid found only in the mitochondrial inner membrane (Mustonen and Kinnunen, 1993).”

It should be noted that, like adriamycin (doxorubicin), fluoroquinolones also cause topoisomerase inhibition and DNA intercalation.  In fact, the mechanism of action for fluoroquinolones is the disruption of topoisomerases, enzymes that are necessary for DNA and RNA replication.  (The “Mechanism of Action” for cipro/ciprofloxacin, as listed on the warning label, is “The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination.”)

Also like adriamycin (doxorubicin), fluoroquinolones bind with and damage cardiolipin, a mitochondrial (and bacterial) membrane lipid.  I suspect that the damage done to mitochondrial cardiolipin by fluoroquinolones is key to understanding fluoroquinolone toxicity.


Cardiolipin and Fluoroquinlones

In order to explain the relationship between fluoroquinolone induced damage of mitochondrial cardiolipin and FQ toxicity, I’m going to attempt to summarize and synthesize information from The Journal of Cell Biology, “Making Heads or Tails of Phospholipids in Mitochondria” and the Journal of Medicinal Microbiology, “Comparison of the effects of subinhibitory concentrations of ciprofloxacin and colistin on the morphology of cardiolipin domains in Escherichia coli membranes.”  I highly recommend that you read the articles yourself though, because there is a lot of information in them that I won’t be able to get to, and, frankly, I may be wrong in my interpretations of some of the information in the articles.

It should be noted that very little is known about mitochondrial phospholipids.  We know how to mess them up through pharmaceuticals and environmental toxins, but we don’t know how to fix them or even detect the damage done to them very well.  It is noted in “Making Heads or Tails of Phospholipids in Mitochondria,” which was published in 2011, that, “Although an increasingly detailed structural and mechanistic picture is emerging for the biogenesis, sorting, and compartmentation of mitochondrial proteins (Schmidt et al., 2010), much less is known about mechanisms regulating the supply of phospholipids and the maintenance of mitochondrial membrane integrity.” (Emphasis added)  It is also stated that, “The biosynthesis of PE (phosphatidylethanolamine) and CL (cardiolipin) occurs, at least in part, within mitochondria and relies on an intricate exchange of precursor forms between the membrane of the ER (endoplasmic reticulum) and the mitochondrial outer membrane at distinct contact sites, whose structural basis we are just beginning to understand.” And, “Specific mechanisms must exist to ensure the transport of phospholipids from the ER to mitochondria and between outer and inner mitochondrial membranes. However, we are only beginning to understand how these transport processes occur and how they are regulated.”  So don’t feel confident at all that even scientists who publish in the Journal of Cell Biology really have any solid answers about how fluoroquinolones, or any other pharmaceutical, mess up mitochondrial membranes.

What is known about cardiolipin (CL) is that it creates “tension in membranes that is likely of functional importance to various mitochondrial processes like membrane fusion or the movement of proteins or solutes across membranes,” and “CL regulates multiple steps of the apoptotic program” (apoptosis is programmed cell death) and CL also plays an important role in protein import into mitochondria.  Additionally, these pictures (taken directly from “Making Heads or Tails of Phospholipids in Mitochondria,” and all credit should go to the authors and publisher) further explain the important role of cardiolipin:


The role of CL in mitochondrial processes. (A) CL (depicted in red) affects mitochondrial energy production and is required for dimerization and optimal activity of the AAC and the formation of respiratory chain supercomplexes. (B) Assembly and activity of protein translocases in the outer (TOM) and inner membrane (TIM22 and TIM23 complexes), the SAM complex in the outer membrane, and the assembly of TIM23 complex with the mitochondrial import motor (PAM complex) is supported by CL. (C) Various roles of CL during apoptosis. (1) Cytochrome c (Cyt c) binds to CL in the inner membrane. (2) Release of cytochrome c upon oxidation of CL. (3) Pro–caspase-8 (pro-8) binds to the surface of mitochondria, oligomerizes, and undergoes autocatalytic processing in a CL-dependent manner. (4 and 5) Bid cleavage to truncated Bid (t-Bid) by pro–caspase-8 (4) and activation and oligomerization of Bax/Bak is stimulated by CL (5). (6) PLS3 allows export of CL from the inner to the outer mitochondrial membrane. (D) CL affects fusion of mitochondrial outer and inner membranes. The phospholipase MitoPLD converts in trans CL into PA (depicted in red), triggering the fusion of outer membranes. CL in the inner membrane stimulates oligomerization and GTP hydrolysis of short Mgm1/OPA1 isoforms. IM, mitochondrial inner membrane; OM, mitochondrial outer membrane.”

Got it?  Yeah, this stuff is hard.  Cardiolipin and the other mitochondrial membranes are important for cellular functioning, and messing up mitochondrial DNA messes up mitochondrial membranes – that’s the gist of it.

Shape Shifting Mitochondria

In “Comparison of the effects of subinhibitory concentrations of ciprofloxacin and colistin on the morphology of cardiolipin domains in Escherichia coli membranes” it was found that “exposure of bacteria to ciprofloxacin significantly increased the percentage of filamentous cells with altered morphology of the cardiolipin domains.”  This finding was surprising to the researchers who authored the study because fluoroquinolones are not supposed to work by disturbing the cell wall of bacteria, they disrupt bacterial DNA reproduction, “but surprisingly, changes were found exclusively in CIP-treated cells.”  (CIP stands for ciprofloxacin.)  They noted that:

“We are not the first to report that DNA topoisomerase inhibition can be followed by the alterations at the level of the bacterial membrane. Dougherty & Saukkonen (1985) showed that inhibition of DNA synthesis by nalidixic acid, a DNA gyrase inhibitor, results in morphological changes consistent with a loss of membrane integrity and leakage of intracellular components. Similar results were presented by Wickens et al. (2000), who noticed a decrease of both membrane integrity and membrane potential after exposure of E. coli to CIP. One of the proposed explanations of this finding is that, as a result of processes induced by inhibition of DNA replication, cells lose their capacity to synthesize necessary components and to maintain the proper membrane structure (Dougherty & Saukkonen, 1985).”

It has been known, SINCE 1985, that fluoroquinolones (the backbone of all fluoroquinolones is naladixic acid) cause “a loss of membrane integrity and leakage of intracellular components.”  Intracellular components, especially minerals, especially magnesium, are pretty important.  Thanks, FDA, and all the other powers that be within the medical/pharmaceutical complex for completely ignoring that valuable piece of information when making use guidelines for fluoroquinolones.  Sigh.

It is also noted in “Comparison of the effects of subinhibitory concentrations of ciprofloxacin and colistin on the morphology of cardiolipin domains in Escherichia coli membranes” that:

“It has also been reported that the unique chemical structure of CL (cardiolipin) allows for trapping of protons and lateral shuttling of them from oxidative phosphorylation complexes to ATP synthase (Haines & Dencher, 2002). This ability determines a unique role of CL as a proton trap within membranes that conduct oxidative phosphorylation and thus ATP synthesis, which suggests why CL is found in membranes which pump protons, e.g. mitochondrial inner membrane and cell membrane of eubacteria (Haines & Dencher, 2002). This specific CL function allows us to speculate that presumably after the fluoroquinolone treatment bacterial membranes maintain CL domains, but (due to membrane perturbation) in altered shapes. Such an effect was observed in our experiments, as CIP treatment induced a significant increase in the number of filamentous cells with FT2 morphology.”

The changing of the shape of mitochondria that is induced by ciprofloxacin induced damage of cardiolipin (and other mitochondrial lipids) is important as well.  In the post on Hormones Matter entitled “Hormones, Hysterectomy and the Aging Brain” it is noted that:

“I just finished writing an extensive paper on acquired mitochondrial illness. Over the course of the research, I stumbled upon a short essay linking mitochondrial structure and function to estradiol. More specifically, the rapid estradiol decline common post oophorectomy (ovary removal), fundamentally alters the shape, and ultimately, the function of mitochondria. (emphasis added)  Researchers found that a rapid decline in estradiol evokes significant damage in the brains (and presumably other body parts) of female monkeys. Additional studies using estradiol starved mitochondria from female rodents showed similar shape alterations and consequent declines in brain bioenergetics. Interestingly though, with natural menopause, where estradiol declines more gradually, no such structural changes were observed. In fact, with the more gradual decline in estradiol the mitochondria appear to increase their production of the lifesaving ATP as a compensatory reaction.”

Mitochondrial shape, which is determined by phospholipid integrity, is connected to hormones and brain health as well.  It’s all connected.  Fluoroquinolones throw a wrench in the whole thing.

Molecular Shape of Mitochondrial Lipids and Possible Solution

It is noted in “Making Heads or Tails of Phospholipids in Mitochondria” that “The non–bilayer-forming lipids PE and CL are more conical shaped with a smaller hydrophilic head group diameter and a relatively larger hydrophobic domain diameter. This shape allows the formation of hexagonal phases that can be observed for isolated lipids depending on the pH and ionic strength” and that, “Early studies with model membranes demonstrated that the formation of hexagonal structures induce membrane fusion and suggested a crucial role of non-bilayer lipids such as CL or PE for membrane fusion in vivo.”

This may be a reach and I could be wrong to connect these things, but the mention of a hexagonal structure made me think of a treatment that has helped several long-time floxies.  The treatment is called Buckminsterfullerene/c60.  In the few articles that I’ve read about Buckminsterfullerene/c60 it appears that the molecular shape is important.  Per the article, “Liposome Formulation of Fullerene-Based Molecular Diagnostic and Therapeutic Agents,” published in Pharmaceutics, “Fullerenes are hollow cage molecules with sp2 carbon atoms arranged in hexagons and pentagons.”   They’re also powerful antioxidants and the results that the floxed friends are getting from supplementing with Buckminsterfullerene/c60 are impressive.

I think that a lot more research needs to be done on Buckminsterfullerene/c60 before it is determined to be an effective or safe treatment for FQ toxicity.  As with everything, do your own research, be careful, know that I’m not a doctor, etc.

Here are a couple of articles about Buckminsterfullerene/c60:

Huffington Post, “Do Buckyballs Extend Lifespan?

Vaughter Wellness, “Aerobic- & strength gains, longevity, brain rejuvenation and tumor prevention with lipofullerene C60 olive oil

It is also noted in “Fullerenes are hollow cage molecules with sp2 carbon atoms arranged in hexagons and pentagons” that, “Fullerene medicine is a new but rapidly growing research subject. Fullerene has a number of desired structural, physical and chemical properties to be adapted for biological use including antioxidants, anti-aging, anti-inflammation, photodynamic therapy, drug delivery, and magnetic resonance imaging contrast agents.”

I don’t currently have enough information to say whether or not Buckminsterfullerene/c60 will help to put your mitochondrial lipids (especially cardiolipin) back together.

But I do think that there is enough information about the severe damage done by fluoroquinolones to mitochondrial lipids that another black box warning for mitochondrial toxicity is warranted.


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23 thoughts on “Fluoroquinolones Damage Mitochondrial Lipids

  1. Lisa Bloomquist January 24, 2015 at 4:40 pm Reply

    The PK Protocol may also help to put mitochondrial lipids back together – http://www.pkprotocol.com/

  2. Don January 25, 2015 at 10:37 am Reply

    Hi Lisa, I first would like to thank you for all of the hard work that you do to give Floxies hope! I was wondering if you had any additional information regarding what symptoms were improved with the Floxies who took the c60? Or any info on their protocols, source, or length of time that they took the c60? Thanks again!

    Sent from my iPhone


    • Lisa Bloomquist January 25, 2015 at 10:47 am Reply

      Hi Don,

      I’m going to refer you to a facebook group where you can ask your question – https://www.facebook.com/groups/FQC60/ There are people in that group who have seen significant improvement after starting C60 supplementation. A couple of the people were long-time floxies who hadn’t seen significant improvement in a while. One of those people has now signed up for a 5k race (or maybe it’s a 10k, I’m not sure). Please keep in mind that none of us in the group are doctors, and that all evidence of C60 helping floxies is anecdotal at this point. Please be sure to look up the pros and cons of this supplement and to proceed with appropriate caution – it’s a more experimental and potentially dangerous supplement than many. With that said, the few results that I’ve heard about are promising.

      Best regards,

  3. The Other Side Of The Stretcher February 3, 2015 at 7:02 pm Reply

    Reblogged this on The Other Side Of The Stretcher and commented:
    The Foxie Hope Blog has a very good post about MITO Toxicity Caused by Flouroquinolones Antibiotics!

  4. […] Dr. Wahls goes over how mitochondrial damage is linked to autoimmune diseases, especially MS.  Fluoroquinolones profoundly damage mitochondria.  Fluoroquinolone toxicity looks and feels a whole lot like multiple autoimmune diseases including […]

  5. Marian May 8, 2015 at 9:24 am Reply

    I want to leave a strong warning note about C60. Half a year ago I had an adverse reaction to ciprofloxacin. I had mild physical problems, but severe cognitive and emotional problems – psychosis, fear, brain fog/depersonalisation, memory loss. I was prescribed antipsychotics and benzodiazepines, both of which led to a severe increase in symptoms.

    Recently I started to recover a little bit. My energy and concentration levels went up, my fear went down and now and then I could be a little bit happy and loving again.

    I decided to try one dose of C60 to see if it could help my recovery.

    After one hour I went outside and noticed a rapid increase of all my symptoms. Fatigue, brain fog/depersonalisation, weird headaches, stomach problems, nausea, etcetera. It has been 5 days now and my symptoms are not getting better, they even seem to get worse. There seems to be a negative response to sunlight and to food.

    I have posted his to Longecity forum and another user there had a similar return of mental floxing symptoms after C60 use, in combination with sun exposure.

    Please take care!

    This is an extremely experimental drug and not much is known about it. Side effects and interactions are still not known and tested.

    • Lisa Bloomquist May 8, 2015 at 10:09 am Reply

      Thank you very much for your input, Marian! I’m so sorry to hear of your bad reaction to C60! I hope that you are able to recover from it. As you say, it is an experimental drug and not much is known about it. Your input and personal experience are valuable and appreciated! I hope that others use caution with it.


  6. Nita Jain July 16, 2017 at 10:13 pm Reply

    I recently found out that one of the reasons I’ve been getting deathly sick after eating fats and proteins has been due to severe carnitine deficiency, required for transporting fats into the mitochondrial. Without carnitine, the fats accumulate, causing organ damage.

    Fullerine is a very long-chain lipid (60 carbon backbone), so it may require substantially more carnitine for transport into the mitochondria.

    I used to suffer severe reactions to coenzyme Q10, which I am deficient in, until I learned about the carnitine and started supplementing with acetyl L-carnitine.

    Adverse reactions to fats and lipid-based supplements could be a sign of carnitine deficiency.

  7. […] via Fluoroquinolones Damage Mitochondrial Lipids […]

  8. Johanna Milford July 28, 2018 at 1:34 pm Reply

    This article fascinated me! My husband was poisoned by FQs mutiple times between 2009-2017.. Cipro was right after a 6 month stay in the hospitals.. horrible horrible drugs!! How do we get them off the market??
    He is doing well.. but it’s a career keeping him good! NrF1 and NrF2 from LifeVantage are the reason he survived!! Survival genes .. wake them up!!

  9. Desiree Ann Parkes November 4, 2019 at 4:27 am Reply

    I am suffering seizure/panic attacks, heart palpatations and breathing problems as a result of taking Ciplox antibiotics which contain fluoroquinolones. I have had 17 seizures/panic attackes since 6th Septemeber 2019. Feeling desparate, frightened and exhausted and under the care of a Neurosurgeon with costly accounts been settled without medical aid help. Feeling desparate!

    • Henk Noordhuizen November 16, 2019 at 7:26 am Reply

      Desiree,this were the first symptoms,I got after 4 Cipro pills.The first heart palpatation I got,after the first pill,almost threw me from my bike.Now,after 3 years,I regret having taken 3 more of those poison pills;I should have stopped,taking them,immediatly,but,brainwashed as we are (“You have to finish the whole course,otherwise you’ll help the bacteria to get resistant!!”).

      I think it’s very important to start supplementing magnesium,as soon as possibble,regarding the heart palptations and the panic attacks your magnesium level is very low.It will take a while,but both symptoms will,over time,get better and might completely vanish.In the meantime;you’d better avoid everything,containing fluoride;medicines,tea,fluoridated toothpaste and fluoridated drinking water;those are no-no’s for floxies.

      The fastest way to improve your magnesium level is magnesium oil (interdermal),and to take a supplement like magnesium-bisglycinate.Magnesium L-Threonate is another popular form;it’s the only form that can easily pass the blood/brain barrier.Might help you to relax a bit and reduce your panic attacks (who wouldn’t panic when suddenly experiencing those heart palpatations?).

      I wish you all the best,and hope that your health will improve,soon!

      • Desiree Ann Parkes November 18, 2019 at 8:46 am Reply

        Dear Henk,

        Thank you so much for the trouble you have gone to as in making me feel that there is light at the end of my huge tunnel.
        At times, I have felt like I am going to die as a result of lack of oxygen. My neurosurgeon wants me to have my heart checked and also wants to admit me for tests to make sure I do not have epilepsy. Everything will cost an arm and a leg and just wonder if I should waste my time.
        At the moment I am on drugs called Redilev to stop the Seizures. Redilev is making me feel awful and would love to try natural healing as I fear the drugs may cause more complications.

        I shall certainly take your advice and try my best to heal myself from this monster disaster.
        Feeling so depressed and desperate and have lost a lot of faith in the medical field.

        Thanking you kindly and hope you have a full recovery from your bad experience.

        Take care,

        Kind regards

        Desiree Parkes

  10. Desiree Ann Parkes November 21, 2019 at 5:41 am Reply

    I would love to keep hearing from people who have negative and positive stories and information as we are all in this together for the same reason. Every little bit of information can give us hope for a healthy body so we can enjoy our lives we all so deserve to in this toxic world.

    • Nita Jain November 23, 2019 at 6:19 pm Reply

      Hi Desiree! I also suffered seizures, psychosis, depression, cardiomyopathy, and many other issues for 4 years post-floxing, but all of that has been reversed now. I no longer suffer from POTS, EPI, CIDP, CVID, or GBS. I’ve been ambulatory and functional for about a year now.

      The Autoimmune Protocol (AIP) diet coupled with FMT helped get me back on my feet. If you’d like to get in touch, feel free to email me at nitajain8@gmail.com

      Wishing you happiness and health,

      • Desiree Parkes November 25, 2019 at 12:02 pm Reply

        Thank you so much Nita Jain for giving me hope and encouragement. Some days feel so hopeless and dark for me. I have never lived in fear of my life as I have in the last 11 weeks since my first seizure.

        I am having my heart checked by my Cardiologist on the 2nd December 2019. My kidney stent surgery took place 4 days after my first seizure. 10th September.

        The surgery was a nightmare as I was also feeling the effects of the Fluoroquinolones as well as the pain from the surgery.

        They cannot do the stent removal without checking that my heart is in good order as my Neurologist is concerned that my seizures are being triggered by my heart.

        I am so pleased to know that you have had an amazing recovery. It makes me feel more positive about my recovery and do realise I need to be positive about my recovery and take good advice from people who have done self healing as you have done.

        I shall be in touch soon!

        Thanks a million!

        From your Floxie Hope Friend


        • Nita Jain December 10, 2019 at 12:07 pm

          Hi Desiree! Hope your cardiologist appointment went well. When I was at my sickest, my cardiopathy responded well to benfotiamine (a fat-soluble version of vitamin B1) and nicotinamide (a reduced form of vitamin B3). Benfotiamine requires magnesium as a cofactor, so I used to take both together for optimum effect. MitoQ sometimes also brought some relief.

          Wishing you restored health this holiday season!

        • Desiree Parkes December 12, 2019 at 3:23 am

          Hi Nita Jain

          Thank you so much for the valuable information, I so appreciate your love, care and dedication.

          My appointment went well with my Cardiologist. He admitted to me that the Fluoroquinolones upset the electricity in my heart and that is why I have responded so well to taking Magnesium and other minerals as in Tissue salts.

          Thank goodness for all the Floxie friends as I would still be having seizures.🤗

          I had a bad time this past week as I had my kidney stent removed after having surgery on the 10th September 2019. All went well but have been feeling very strange and feel that it has to be the anaesthetic reacting with the Fluoroquinolone poison. I have been having a lot more body pain and a pressure feeling on the brain which makes me feel like I am floating some days.😪

          Not one of my doctor’s – GP, Neurologist, Cardiologist suggested magnesium or any supplements. At the moment I am on medication for epilepsy prescribed by my neurologist to control the seizures but I am slowly reducing the dose on my own accord as I am not happy about taking them. The neurologist was certain that my seizures were being triggered by my heart.

          I have no idea how long it will take for me to feel normal again. My hearing has deteriorated as well as my macular eye disease which is blood vessels bleeding behind the macular and causes blurred eye vision. I have eye injections once a month in my right eye to control the bleeding and hopefully it will stop as time does heal.

          I have been meaning to respond to you when we had our first chat but my mother had a near fatal Pulmonary Embolism, she is a lucky lady to be alive as the clot that went into her lung is a large one. She has been in hospital for 9 days now under the care if a good Physician.

          Take care and I wish you all the best in health and look forward to chat in the near future. Xxx


        • Nita Jain December 24, 2019 at 7:59 pm

          Hi Desiree, I’m so sorry to hear about your surgery and your mom’s struggles. I hope your health improves and your mom recovers and can return home soon!

          I also experienced a lot of hearing and vision problems post-Cipro; an ophthalmologist had diagnosed me with an inflammatory eye disease and a holistic eye practitioner told me I had chronic dry eye as well. One floxie suggested I try AREDS2, but I couldn’t tolerate it due to soy and other ingredients. Beef liver has been somewhat helpful. I still deal with tinnitus but don’t pay much attention to it these days.

          Over the past several weeks, I began experiencing a relapse of ataxia, paresthesias, seizures, and arrthythmias and my B12 levels recently came back low. I required shots for most of 2017, so I suppose that I should continue to monitor this.

          Please take care and enjoy the holidays as much as your health allows!

        • Desiree Parkes December 27, 2019 at 7:17 am

          Hi Nita,

          I’m so sorry to know that you have had a relapse. I have just realised that I suffer from the exact same symptoms as you have.😪 I have been taking lots of magnesium and pleased to say that I have only had 1 seizure since taking magnesium and the 12 Tissue Salts daily. I will definitely have my B12 levels checked. My Neuroligist prescribed Epilepsy medication which was a 3 month nightmare as I felt like my brain had so much pressure and suffered from depression and often feeling like “I cannot do this” 😢 I slowly weaned myself off the drug. He also prescribed Ativan to take when a seizure starts. Hopefully I can stay drug free taking supplements and eating healthy. My mother is home after 2 weeks in hospital and managing her oxygen well at the moment, thank you for asking.🤗 My eye sight is of great concern to me at the moment as I have Macular Degenerative Disease and have injections once a month in my right eye. My eye sight has deteriorated and have swirls of silver watery looking patterns all the time, almost like heat waves. I am taking an eye supplement Eyes RX Plus which is a South African product. I wish you all the best with your B12 shots. Hopefully with a healthy diet and supplements we may get back to where we were before Cipro. Let us both be positive for 2020 and hopefully we can have some positive feedback for each other and for everyone else suffering Post Cipro.

          Take care and will be in touch. I hope your New Year will bring positive things for you.

          Much Love


      • Desiree Parkes January 23, 2020 at 12:51 pm Reply

        Thank you so much Nita Jain for giving me more hope and encouragement. Some days feel so hopeless and dark for me. I have never lived in fear of my own life as I have done in the last 11 weeks since my first Seizure.

        I am having my heart checked by a Cardiologist on the 2nd December as I am having a stent removed from my kidney on the 5th December. My kidney stent surgery took place 4 days after my first seizure.

        They cannot operate without checking that my heart is in good order as my Neurologist was concerned that my seizures/panick attacks are being triggered by my heart.

        I am so pleased to know that you have had an amazing recovery. It makes me feel more positive about my recovery and do realise I need to be positive and take good advice from people who have done self healing.

        I shall be in touch soon!

        Thanks a million!

        Kind Regards

        Desiree Parkes

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