Is Fluoroquinolone Toxicity Quinolone Toxicity or Fluorine Toxicity?

Cipro Molecular Structure

As should be obvious from their name, FLUOROquinolones are fluorinated drugs.

A little history for you: Nalidixic Acid is the backbone of all fluoroquinolones. It was discovered by George Lesher in 1962, and it started to be used as an antibiotic in 1967. Nalidixic acid, and the first-generation quinolones that were derived from it, were not widely used because they lacked bioavailability and were associated with the rapid development of bacterial resistance (1). To increase bioavailability, a fluorine atom was added to the nalidixic acid backbone at position 6, bonded to carbon (2 and 3). This increased bioavailability of the quinolones greatly, and their use increased exponentially (more than 26 million prescriptions for fluoroquinolones were given out in 2011 alone).

In addition to increasing the bioavailability of fluoroquinolones, did the addition of the fluorine increase the toxicity of the fluoroquinolones?

How much of Fluoroquinolone Toxicity is due to the quinolone core and how much of it is due to the fluorine addition that, as it is intended, penetrates cells and increases the quinolone efficacy and potency? Is Fluoroquinolone Toxicity quinolone toxicity, or is it fluorine toxicity?

I’ve always been of the opinion that the quinolone core is toxic and that the fluorine just increases the bioavailability and toxicity of the quinolones, and that fluoroquinolone toxicity is quinolone toxicity, not fluorine toxicity. However, recently I’ve been reading about the effects of fluoride, and, more specifically, fluoro-organic metabolites like fluoracetate and fluorocitrate, and I have been considering the possibility that fluoroquinolone toxicity is a result of the addition of the fluorine atom to the quinolone core. I intend to explore the possibility that fluoroquinolones are metabolized into poisonous metabolites like fluoracetate and fluorocitrate in future posts. In this post, I’ll start the conversation by looking at some evidence that the quinolone core is the toxic part of fluoroquinolones, as well as some evidence that the fluorine is the main source of toxicity.

There is a lot of grey area in the question of whether fluoroquinolone toxicity is caused by the quinolone core, the fluorine attachment, or both. It is likely, in my opinion, that both are toxic. There are undoubtably complex feedback and feed-forward loops in our biochemistry that may make one increase the toxicity of the other too.

fluoroquinolone-lawsuit-banner-trulaw

Argument #1 – Quinolones were toxic before the fluorine was added.

Nalidixic acid and the first-generation quinolones that weren’t fluorinated, have serious and severe adverse effects. For example, Cinoxacin, a first-generation unfluorinated quinolone, has the following adverse-effects (4):

  • difficulty breathing
  • fever
  • increased sensitivity to the sun or ultraviolet light
  • irregular heartbeat, palpitations, or chest pain
  • joint, muscle, or tendon pain
  • nervousness, restlessness, anxiety
  • severe stomach or abdominal pain
  • severe or watery diarrhea
  • seizures (convulsions)
  • skin rash or itching
  • swelling of the face or neck
  • vomiting
  • diarrhea (loose stools)
  • difficulty sleeping
  • dizziness, drowsiness
  • headache
  • nausea
  • stomach upset

In a study of 1,118 patients who took Cinoxacin, it was found that many experienced the following (5):

Gastrointestinal: Nausea was reported most commonly and occurred in less than 3 in 100 patients. Other side effects, occurring less frequently (1 in 100), were anorexia, vomiting, abdominal cramps/pain, perverse taste, and diarrhea.

Central Nervous System: The most frequent side effects were headache and dizziness, reported by 1 in 100 patients. Other adverse reactions possibly related to Cinobac (cinoxacin) include insomnia, drowsiness, tingling sensation, perineal burning, photophobia, and tinnitus. These were reported by less than 1 in 100 patients.

Hypersensitivity: Rash, urticaria, pruritus, edema, angioedema, and eosinophilia were reported by less than 3 in 100 patients. Rare cases of anaphylactic reactions have been reported. Toxic epidermal necrolysis has been reported very rarely. Erythema multiforme and Stevens-Johnson syndrome have been reported with cinoxacin and other drugs in this class.

Hematologic: Rare reports of thrombocytopenia.

Though those aren’t comprehensive lists of fluoroquinolone toxicity symptoms, they’re pretty close. Even reviews of modern fluorinated fluoroquinolones rarely have more comprehensive lists of adverse-effects than the lists for Cinoxacin above.

Argument #2 – The fluorine increases the toxicity so much that it is largely responsible for fluoroquinolone toxicity.

From various publications:

“Fluorinated C-6 position was shown to contribute to an overall toxicity of the molecule and its CNS activity” (6).

“Fluoroquinolone antibiotics may cause tendon pain and rupture… The non-fluorinated quinolone nalidixic acid had lesser or no effects” (7).

“Although the etiology of fluoroquinolone-associated muscle disorders has yet to be fully elucidated, evidence supports a relationship with both latent myopathic disorders and the fluorine atom in fluoroquinolones… Further support for the hypothesis that fluorine may be the trigger for fluoroquinolone-associated myopathy comes from the fact that no adverse muscular events have been reported with unfluorinated quinolones” (8).

“The potential of this non-fluorinated series became clearer when two independent reports showed that non-fluorinated quinolones were consistently less genotoxic than their 6-fluorinated counterparts” (9).

Argument #3 – The fluorine is toxic, and fluoroquinolone toxicity is fluoride toxicity.

This post would be way too long if I went into detail about this argument, but I will note that the symptoms of fluoride toxicity are similar to the symptoms of fluoroquinolone toxicity. Fluoride toxicity is a multi-symptom, chronic illness that affects all systems in the body….. just like fluoroquinolone toxicity. There are people who have been exposed to other sources of fluoride who have very similar symptoms to those of people who have been “floxed.”

Conflicting Evidence

I suspect that the reason for the conflicting evidence presented above is that long-term studies of fluoroquinolones (and of other sources of fluorine/fluoride) have never been done–or, if they have been done, they have not been responded to appropriately, as there is no movement (that I’m aware of) to stop the fluorination of drugs, and the movements to stop the fluoridation of water constantly run up against obstacles including the accusation of being “conspiracy theorists.” In the short-term, and after limited exposure, many people (and lab rats) are fine. It is only after an accumulation of cellular damage occurs that a threshold is crossed, and multi-symptom, chronic illness results. In the post, The Fluoroquinolone Time Bomb – Answers in the Mitochondria, I go over the delayed reactions and tolerance thresholds that occur with fluoroquinolone adverse reactions. It should be noted that fluoride also accumulates in the body, there is a tolerance threshold for it, and fluorine metabolites damage mitochondria. In order to see the damage that is done by fluoroquinolones (and possibly other sources of fluoride like other fluorinated drugs, PFCs, and even fluoridated water) long-term studies need to be done. Studies that only examine a short exposure to fluoroquinolones, and that don’t look at adverse reactions that occur weeks, months, or even years after exposure to the drug has stopped, are not approaching these drugs appropriately. Short-term studies show that these drugs are less risky than they actually are in the long term, and/or after repeated exposure. Long-term studies are needed to show the real risks of fluoroquinolones.

Anecdotes

I recovered while drinking fluoridated water and using fluoridated toothpaste. I have never noticed any immediate ill effects from fluoride exposure.

However… some people have recovered from fluoroquinolone toxicity primarily through cutting all sources of fluoride from their lives. They have avoided fluorinated water for drinking, cooking/eating, and bathing, and have felt markedly better while avoiding fluoride. They notice that even small exposures to fluoride make them feel worse.

Nonconclusion

I honestly don’t know what to conclude. I think that both the quinolone core and the fluorine atom are dangerous. It’s undeniable that the fluorine makes the quinolone more powerful, and more dangerous. I am also starting to see that fluorine in itself can cause severe cellular damage. Fluorine is an undeniably reactive element that can bind to (and deplete) minerals, disrupt enzymatic reactions, and it may be wreaking havoc on those who exceed their tolerance for it.

BUT… the quinolone core is dangerous too. People can legitimately argue that there are many, many sources of fluorine in the world (20% of all prescription drugs are fluorinated, water and toothpaste are fluoridated, nonstick products like Teflon are fluorinated, air pollution has a lot of fluorine in it, etc.) and people who are exposed to those things don’t get “floxed.”

BUT… maybe we need to look beyond the people who are dealing with fluoroquinolone toxicity, and look at the bigger picture of multi-symptom, chronic, mysterious diseases. I’m honestly not sure if the many diseases of modernity that have increased along with both fluoroquinolone use and the increase in overall exposure to fluoride—like autoimmune diseases, neurodegenerative diseases, mysterious diseases like fibromyalgia and ME/CFS, mitochondrial diseases, autonomic nervous system diseases, autism, etc.–have anything to do with fluorine/fluoride exposure, or not. Studies, especially appropriately long-term studies, that examine the various sources of fluorine/fluoride, and their cumulative effects, haven’t been done. (Most people assume that things like this have been looked at thoroughly. Don’t assume that–they haven’t been.)

Action Plan

Whether we’re dealing with quinolone toxicity or fluorine toxicity, the result is mitochondrial damage and dysfunction, oxidative stress, mineral depletion, a disrupted microbiome, and more. Research on antioxidant supplementation has shown promising results for floxies, and for people dealing with the more recognized diseases of modernity. Mineral replacement is recommended whether cellular minerals are being displaced by the quinolone core or the fluorine. The healing tips noted in the stories on Floxie Hope, and the supplements and other protocols mentioned in The Fluoroquinolone Toxicity Solution, are helpful. Cutting fluoride exposure is also recommended by many “floxies,” and perhaps avoiding all sources of fluoride (fluoridated water, toothpaste, many supplements and pharmaceuticals contain fluorine, and nonstick products like teflon do as well) will be the key for healing for you. I know that avoiding fluoride and fluorine has helped others to heal.

Sources:

  1. The Canadian Journal of Infectious Diseases, “Safety of fluoroquinolones: An update
  2. Dartmouth, “Deconstructing Molecules: Cipro
  3. International Journal of Comprehensive Pharmacy, “SYNTHESIS OF NEW LEVOFLOXACIN DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY
  4. University of Utah Health Care, “Cinoxacin capsules
  5. RxList, “Cinobac Side Effects Center
  6. German, NA, Design and synthesis of novel molecules for overcoming bacterial resistance to fluoroquinolones. The University of Iowa 2007, p. 16.
  7. Rheumatology, “Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells
  8. Physical Medicine and Rehabilitation (PM & R) “Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population
  9. Current Medicinal Chemistry, “Discovery, Structure-Activity Relationships and Unique Properties of Non- Fluorinated Quinolones (NFQs)

 

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37 thoughts on “Is Fluoroquinolone Toxicity Quinolone Toxicity or Fluorine Toxicity?

  1. Linda January 7, 2016 at 11:44 am Reply

    I can check off all but one in that long list of side effects from quinolones alone, but I would guess that both are responsible, especially knowing now how toxic fluoride is. I wonder if the pill that Stephen Fried’s wife took (“Bitter Pills”) had a fluoride component?

    • Lisa Bloomquist January 7, 2016 at 12:15 pm Reply

      Stephen Fried’s wife, Diane, took Floxin (ofloxacin). It’s a fluoroquinolone (fluorinated).

  2. Debs January 7, 2016 at 2:06 pm Reply

    When it comes to looking at the nucleus in order to get a very comprehensive picture i feel strongly that the whole picture, the full history of the FQs far further back than the original Quinolones needs to be researched & included, as our various injuries are found in various patterns in various drugs way back in time, past the original non fluorinated Quinolones right back to synthetic Quinine. in my humble opinion to understand the whole picture is so very important. In my own research I include the quinolines as part of this picture & personally went right back to the source, the chinchona bark, the alkaloids .
    For anyone who is unaware, In the drugs in which our various injuries can be found in various patterns, all these drugs have the QuinoLINE ring the nucleus in common . The QuinoLINE ring is the nucleus of Quinine, Mefloquine, the 4-aminoquinolines, the 8-aminoquinolines, It is also the nucleus of the FQs.

    For anyone interested in the full history of that QuinoLINE nucleus, this hisory can be found under ‘ links & resources ‘ above, scroll down to ‘ other research ‘ where can be found a dropbox file, this file contains the archives of research from the Fluoroquinolone toxicity research foundation. you can find this information under ‘ ‘ History of the Fluoroquinolones ‘.

    I personally feel their are multifactorial issues which are beyond complicated, when we start widening the net to include other toxins environmental issues, drugs etc etc, & how the FQs interact with these & each persons unique variables it is simply mind-blowing, add in the complexity of fluorides, & we then get another how long is a piece of string scenario with so many knots I wonder if it will ever be untangled.
    All I know is that thinking about the sheer complexity of it all, just makes what’s left of my floxed brain hurt .

  3. Debs January 7, 2016 at 2:09 pm Reply
  4. Debs January 7, 2016 at 2:59 pm Reply

    In respect of fluorides numerous people are hypersensitive, & when it is cut out as much as humanely possible, many people whether they are floxed or not find they do begin feeling better. It is something I feel is so very important to do. I found an interesting study showing the effects of even small amounts on the body / brain.

    http://fluoridealert.org/wp-content/uploads/aksyuk-1962.pdf

  5. Lisa Bloomquist January 7, 2016 at 3:04 pm Reply

    Thank you, as always, for your thoughtful insight, Debs!

  6. Jason January 7, 2016 at 6:31 pm Reply

    Fortunately, “Studies, especially appropriately long-term studies, that examine the various sources of fluorine/fluoride, and their cumulative effects, haven’t been done.” – this is not really true, LOTS have been done, sure more would be nice, although totally unnecessary, its a PROVEN LETHAL TOXIN on MANY different levels to the Human/Animal bodies, not sure what else really needs to be known, its needs to be avoided, period, as the studies HAVE shown, buried, or not. Dr. Dean who worked 35 years at the Cancer Institute stated that, “In point of fact, Fluoride causes more Human Cancer Death, and causes FASTER than any other chemical”, you don’t really think he went on record with that statement without studies and facts to back it up I hope.

    My research, which goes back at least 15 years (on Fluoride), and has compiled a folder of a thousand or more documents/studies etc, would agree with the “study-backed” points above made under #2 , the Quins were less toxic before the Fluorine was added, which only makes sense, since if you take toxic drug “A”, and add a proven lethal toxin to it, the result “B” is of course a much more toxic drug, and really the list for Nalidixic acid (and the others like it, I DID go deep and way back into the history of Quins) and what the studies show for it, while not pleasant (the list for ANY drug never is, hell just look at the side effects for something as simple as Nexium http://www.rxlist.com/nexium-drug/side-effects-interactions.htm), pales in comparison to the full list for both Fluorine/Fluoride toxicity and Fluoroloquinolone Toxicity, which both look near identical

    • Lisa Bloomquist January 8, 2016 at 6:55 am Reply

      Edited – “or, if they have been done, they have not been responded to appropriately, as there is no movement (that I’m aware of) to stop the fluorination of drugs, and the movements to stop the fluoridation of water constantly run up against obstacles including the accusation of being ‘conspiracy theorists.'”

      Links are always appreciated.

      There is certainly a shortage of studies that note the long-term effects of fluorinated drugs. I haven’t seen any that connect them to chronic illnesses. Maybe I’m not looking in the right places. Feel free to send them over.

      Thanks, as always, for your knowledge!

      Regards,
      Lisa

      • Jason January 8, 2016 at 11:37 am Reply

        Hi Lisa. I am still reading the same quote, right above the bolded action plan title, “Studies, especially appropriately long-term studies, that examine the various sources of fluorine/fluoride, and their cumulative effects, haven’t been done.”

        What it seems like from your comment here, is maybe what you wanted to say then is, “fluorine/fluoride, and their cumulative effects once added to drugs” – There you might have a good point I am not sure, because I have never researched drugs themselves in any depth (other than the Quins…) as I know what I need to about them, they are chemical based and thus all toxic and best avoided (and yet, I was dumb enough to still take them, the joys of a weak immune system, and oh, they’re just antibiotics…famous foolish last words, I really should have known better).

        For Fluorine/Fluoride itself, there is tons of info/studies out there, and while in many cases they do not “directly” link to disease (in some they do), as that in and of itself is very difficult to “prove”, conclusively (like Aluminum & Alzheimers, Vaccines & Autism, etc), 2 + 2 still does equal 4, so if for example Fluoride is proven to damage Thyroid (among many many other things) then it seems pretty safe to conclude long term exposure is going to cause big problems and possibly Thyroid Disease (IIRC I am quite sure studies have linked it to both Hashimotos and Graves, it used to be used as “drug” to suppress the Thyroid, in the words of Walter Last, “Until the 1970’s Fluoride was prescribed by doctors as thyroid-suppressing medication for patients with an over-active thyroid).

        Also with regards to Drugs, the same principle applies, if it is toxic all by itself, I’m not really sure we need studies to tell us just how much worse the already toxic drugs become, and considering Fluorine/Fluoride crosses the Blood Brain Barrier and accesses the CNS directly in such a dangerous fashion, that alone means big trouble

        Yes, some people live their lives exposed to “F” and are “seemingly”(key word there) unaffected, yet studies prove “F” accumulates in the body, and when enough accumulates a threshold is passed and people end up with Fluoride Toxicity in one or many different manifestations. Of course some people will clear “F” from the body better than others too, so many variables, Genetics, diet, environment, current exposure, etc so those two things combined people can look at it and try to come to a bit of a “non-conclusion” (like those who still argue it’s safety…), however, the studies and facts are there going back until at least the 1930’s (probably even further), that is how much has been compiled.

        I hope my main point is more clear, sorry my tone might have been a bit ‘off’ last night, I received some very disturbing news. Many of the smartest, non-corrupted experts, who are dealing with and solving people’s “Diseases” daily, agree on the main causes of those “Diseases”: Toxins (Medicine, Metals, Halides, etc), Food, Water, Viruses/Bacteria/Fungus, and many of these negatively affect the Gut which is why it is often the common denominator. Truly Medicine, Fluoridated or not, is the most common and widespread toxin, and thus the biggest cause of most Disease today, and more people are coming to this conclusion, like my friend Mr. last 40 years in the Health Industry: “I am now fully convinced that most diseases are indeed caused by the medical system, and in the following I want to state my reasons for this conclusion.” http://www.health-science-spirit.com/medicaldisease.html

      • Jason January 8, 2016 at 11:55 am Reply

        There is just so much info out there, I’ll post just a few things here and maybe I’ll add to it over time.

        This was a pretty good related article, and has some info on drug “Baycol” from Linda’s favourite company Bayer. Note the 38 references/studies in this one, which them themselves are linked to even more references and studies

        http://www.westonaprice.org/health-topics/the-true-story-of-cipro/

        The whole article is good, Linda will like this quote, “The liver has been identified as a target organ of fluoroquinolone toxicity in animal studies.23 As early as the 1930s, scientists at Bayer and Knoll had discovered that all organic fluoride compounds tested (including those used for fluoroquinolone production) interfered with thyroid hormone activity in liver and muscle tissue.

        Don’t forget to look into all the Quins that were yanked off the market, and WHY, like these two it mentions: “Temafloxacin and grepafloxacin are two other fluoroquinolones now withdrawn from the market because they had caused severe liver and renal damage–and deaths, just like fluorinated drugs from other, different classifications, such as Baycol.3The same information also exists for Cipro, Fatal liver failure associated with ciprofloxacin was reported in the Lancet in 1994.7,8
        Ciprofloxacin has been implicated in several cases of acute renal failure and is the fluoroquinolone most established to cause such renal dysfunction.4,9,10,11”

        “Ciprofloxacin administration always results in elevated serum fluoride levels.12 In a series of tests evaluating the safety of ciprofloxacin in children, serum fluoride levels increased after 12 hours in 79 percent of the children; on day 7 the 24-hour urinary fluoride excretion was higher in 88.9 percent of children observed.12”

      • Jason January 8, 2016 at 12:30 pm Reply

        Just one of the references from above, which goes into some more detail about more Fluoridated drugs pulled off the market and why

        http://articles.mercola.com/sites/articles/archive/2001/08/18/fluoride-drugs.aspx

      • Jason January 8, 2016 at 12:37 pm Reply

        Some studies on Pineal Gland linked here:

        http://fluoridealert.org/issues/health/pineal-gland/

        “studies have found that calcified deposits in the pineal are associated with decreased numbers of functioning pinealocytes and reduced melatonin production (Kunz et al., 1999) as well as impairments in the sleep-wake cycle. (Mahlberg 2009).”

        A reason or “another” reason for so much FQ induced Insomnia? The “Coincidences” that stack up are enormous, whether there are studies proving without a shadow of a doubt the effects, or not

      • Jason January 8, 2016 at 12:42 pm Reply

        I think I linked this one recently somewhere:

        http://www.stopthethyroidmadness.com/fluoride-and-your-thyroid/

        “Scientific Facts on the Biological Effects of Fluorides

        Fluoride exposure disrupts the synthesis of collagen and leads to the breakdown of collagen in bone, tendon, muscle, skin, cartilage, lungs, kidney and trachea. A.K. Susheela and Mohan Jha, ” Effects of Fluoride on Cortical and Cancellous Bone Composition,” IRCS Medical Sciences: Library Compendium, Vol. 9, No.11, pp. 1021-1022 (1981); Y. D. Sharma, ” Effect of Sodium Fluoride on Collagen Cross-Link Precursors,” Toxicological Letters, Vol. 10, pp. 97-100 (1982); A. K. Susheela and D. Mukerjee, ” Fluoride poisoning and the Effect of Collagen Biosynthesis of Osseous and Nonosseous Tissue,” Toxicological European Research, Vol. 3, No.2, pp. 99-104 (1981); Y.D. Sharma, ” Variations in the Metabolism and Maturation of Collagen after Fluoride Ingestion,” Biochemica et Biophysica Acta, Vol. 715, pp. 137-141 (1982); Marian Drozdz et al., ” Studies on the Influence of Fluoride Compounds upon Connective Tissue Metabolism in Growing Rats” and “Effect of Sodium Fluoride With and Without Simultaneous Exposure to Hydrogen Fluoride on Collagen Metabolism,” Journal of Toxicological Medicine, Vol. 4, pp. 151-157 (1984).

        Fluoride stimulates granule formation and oxygen consumption in white blood cells, but inhibits these processes when the white blood cell is challenged by a foreign agent in the blood. Robert A. Clark, “Neutrophil Iodintion Reaction Induced by Fluoride: Implications for Degranulation and Metabolic Activation,” Blood, Vol. 57, pp. 913-921 (1981).

        Fluoride depletes the energy reserves and the ability of white blood cells to properly destroy foreign agents by the process of phagocytosis. As little as 0.2 ppm fluoride stimulates superoxide production in resting white blood cells, virtually abolishing phagocytosis. Even micro-molar amounts of fluoride, below 1 ppm, may seriously depress the ability of white blood cells to destroy pathogenic agents. John Curnette, et al, ” Fluoride-mediated Activation of the Respiratory Burst in Human Neutrophils,” Journal of Clinical Investigation, Vol. 63, pp. 637-647 (1979); W. L. Gabler and P. A. Leong, ., ” Fluoride Inhibition of Polymorphonumclear Leukocytes,” Journal of Dental Research, Vol. 48, No. 9, pp. 1933-1939 (1979); W. L. Gabler, et al., ” Effect of Fluoride on the Kinetics of Superoxide Generation by Fluoride,” Journal of Dental Research, Vol. 64, p. 281 (1985); A. S. Kozlyuk, et al., ” Immune Status of Children in Chemically Contaminated Environments,” Zdravookhranenie, Issue 3, pp. 6-9 (1987)

        Fluoride confuses the immune system and causes it to attack the body’s own tissues, and increases the tumor growth rate in cancer prone individuals. Alfred Taylor and Nell C. Taylor, ” Effect of Sodium Fluoride on Tumor Growth,” Proceedings of the Society for Experimental Biology and Medicine, Vol. 119, p. 252 (1965); Shiela Gibson, ” Effects of Fluoride on Immune System Function,” Complementary Medical Research, Vol. 6, pp. 111-113 (1992); Peter Wilkinson, ” Inhibition of the Immune System With Low Levels of Fluorides,” Testimony before the Scottish High Court in Edinburgh in the Case of McColl vs. Strathclyde Regional Council, pp. 17723-18150, 19328-19492, and Exhibit 636, (1982); D. W. Allman and M. Benac, ” Effect of Inorganic Fluoride Salts on Urine and Cyclic AMP Concentration in Vivo,” Journal of Dental Research, Vol. 55 (Supplement B), p. 523 (1976); S. Jaouni and D. W. Allman, ” Effect of Sodium Fluoride and Aluminum on Adenylate Cyclase and Phosphodiesterase Activity,” Journal of Dental Research, Vol. 64, p. 201 (1985)

        Fluoride inhibits antibody formation in the blood. S. K. Jain and A. K. Susheela, ” Effect of Sodium Fluoride on Antibody Formation in Rabbits,” Environmental Research, Vol. 44, pp. 117-125 (1987)

        Fluoride depresses thyroid activity. Viktor Gorlitzer Von Mundy, ” Influence of Fluorine and Iodine on the Metabolism, Particularly on the Thyroid Gland,” Muenchener Medicische Wochenschrift, Vol. 105, pp. 182-186 (1963); A. Benagiano

        • Jason March 30, 2016 at 2:24 pm

          In some of my old posts on this page https://floxiehope.com/comment-page-41/#comments I posted more information about the Collagen and Collagen synthesis destruction (aka Joint, Tendon & other issues), and more ways to try and combat it.

          You will need to use your Internet Browser’s “Search the Page” feature, and search the page for “10:27” (my first post on the subject) and you will find about 10 posts with information, links to websites with more information, studies etc.

          The following posts are where you will more info on this on that page:

          Jason November 8, 2015 at 10:27 am
          Jason November 8, 2015 at 10:47 am
          Jason November 8, 2015 at 10:49 am
          Jason November 8, 2015 at 10:52 am
          Jason November 8, 2015 at 10:37 pm
          Jason November 8, 2015 at 10:58 pm
          Jason November 8, 2015 at 6:43 pm
          Debs November 9, 2015 at 5:16 am
          Jason November 9, 2015 at 10:25 am
          Mark S November 9, 2015 at 11:13 am
          Jason November 11, 2015 at 12:49 pm

      • Jason January 8, 2016 at 12:45 pm Reply

        26 references in this one

        http://articles.mercola.com/sites/articles/archive/2015/06/14/fluoride-health-effects.aspx

        Water Fluoridation Linked to Higher Prevalence of ADHD

        Elevated Hypothyroidism Rates Linked to Fluoride Consumption in the UK

        Fluoride Is an Endocrine Disruptor

        New IQ Study Links Fluorosis to Neurotoxicity

        HHS Admits Overexposing Americans to Fluoride

        Fluoridegate: New Evidence of Government Cover-up

      • Jason January 8, 2016 at 12:51 pm Reply

        A picture, or in this case a short video, is worth a thousand or more words, Debs posted this one back in Feburary, VERY disturbing

        Proof that Fluoride damages the Mitochrondria, note this is one part in THIRTY million, not the “One PPM” “deemed” safe all those years ago. (they even note one part in 60 million was very similar)

      • Jason January 8, 2016 at 12:55 pm Reply

        A good almost 3 hour documentary

      • Jason January 8, 2016 at 12:57 pm Reply

        Another very good documentary

      • Jason January 8, 2016 at 1:04 pm Reply

        More info on the Brain, Mitochondria, another Iodine connection, importance of anti-oxidants and more, all study backed about 30 or 40 total here:

        http://fluoridealert.org/studies/brain04_/

        The animal research also includes over 40 studies that have investigated fluoride’s impact on various parameters of brain quality. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

        “Excessive intake of fluoride results in an altered mitochondrial distribution in axon and soma in cortical neurons (i.e., the increase in soma and the decrease in axon), increased expression of Fis1 gene and enhanced mitochondrial fission.

        fluoride’s toxic effects on brain cells are significantly worse in the presence of iodine deficiency (a finding consistent with current research on human intelligence) and aluminum excess;

        fluoride’s effects are reduced by increased intake of anti-oxidants

        the SOD/MDA ratio in this high fluoride and low iodine group was consistently lower than in the control group. These results suggest that [oxidative] stress from high fluoride and low iodine is one of the causes of reduction in learning and memory in offspring rats.”

        Much more there

      • Jason January 8, 2016 at 1:27 pm Reply

        These are only a tiny tiny tip of the Iceberg here, I could keep going for days possibly weeks, and in fact over the last 11 months I have posted a good number of things in the main pages (including what people have done successfully and what new people can do about it, Iodine, Borax/Boron, Tamarind, Lecithin & more, study backed and expert recommended), but I think the main point I wanted to make has been driven home already

  7. Charlett Hobart January 7, 2016 at 10:29 pm Reply

    Dear Lisa, Thank you for this post and for, at last, asking this most overlooked question
    about Fluorides and putting it out there for all us Floxies to take into account. Thank you Charlett Hobart

  8. Lisa Bloomquist January 15, 2016 at 1:20 pm Reply

    This is a good video too. It’s only 13 minutes long, for those who don’t have much time –

  9. Jason January 16, 2016 at 3:45 pm Reply

    I think I may have forgot to mention another good book on the topic, “The Fluoride Deception”, based on the Authors 10 years of research.

    The unfortunate part of Water Fluoridation, is it makes it VERY hard to avoid, and remove from the water as well (almost all filters do NOT remove it), and you end up absorbing it in your bath and shower, and it ends up in the food supply as well, like in almost ALL foods, grown, or manufactured since water is integral to the process, plants must be watered etc

    Tiny example of Fluoride PPM in some foods (it IS everywhere, so affecting people whether they realize it, or not, which is why the importance of Iodine and other things is being stressed by many Alternative Health Experts):

    Minute Maid orange Juice 1.22ppm
    Snapple 29ppm
    Dole Pineapple Juice 78ppm
    Lucerne 2% milk 72ppm
    CocaCola Classic 82ppm
    Hansens Soda 45ppm
    Capri Sun Juice .37ppm
    Gerber Strawberry Juice 1.80ppm
    Horizon Milk (organic) .22ppm
    Sunny Delight .31ppm
    Pepsi .37ppm
    Knudson Recharge .37ppm
    Gerber White Grape Juice 3.50ppm

    Anyway here is a 28 minute video interview with the Author Christopher Bryson of the book, “The Fluoride Deception”: (The book is much more comprehensive of course but this video has some interesting info & tidbits in it too)

  10. Jason January 17, 2016 at 2:08 pm Reply

    A compilation of many links to more info on their site and external others here

    http://www.whale.to/d/fluoride.html

  11. Jason January 20, 2016 at 11:35 am Reply

    Did a little experiment last night, my teeth have been a little sensitive for a few days so I decided just for fun (I am 95% healed and have been for 6 months) to put some “sensidyne” toothpaste on them, which contains Fluoride, I left it on for one minute only. I have had NO leg twitching at all for at least 3 or 4 weeks so it was a good time to “try” this, I have been sick and not exercising (which is when very minor twitching can come back)

    After one hour, very minor twitching started, and it was there in the morning as well right on waking where I am obviously not “thinking about it”. I’ve noted before that the “Placebo” effect really does not work on me, I’ve taken hundreds of supplements with “hope” and got nothing, and there are many other examples.

    I did not do this for myself (other than wanting a big of relief on teeth) but to show others what I already know, Fluoride is a BIG problem, whether people actually realize and “notice” or not. We have had people get completely “Re-Floxed” from Dentist treatments where Fluoride was given, from Fluoridated drugs almost every single time, and we have had people have their symptoms “completely disappear” by leaving the Country and going to a non-Fluoridated one (note they did not realize this at the time) only for the symptoms to return with a couple of days of coming back and starting their “Daily Fluoride Shower”.

    There is no doubt in my mind all forms of Fluorine and Fluoride are things that can prolong someone’s healing, and even prevent it in some cases. Its possible that some people when Floxed did not cross their “Fluoride threshold” and just suffered some acute damage and symptoms etc so would be “less” sensitive it over a little time then those who have, but I don’t suspect this would be very common, and I believe crossing that threshold is a big reason many people get Floxed (actually notice that is) in the first place.

    • Jason January 21, 2016 at 9:40 pm Reply

      No doubt about it, that little bit of toothpaste causes a bit of a re-floxing and/or a re-poisoning, even had some Floxie “back pain” today, one of my very first symptoms when Floxed. This is not the first time “Fluoride” has done this, not even close, it is the first time for toothpaste though as I have avoided it. Other exposures that I actually know about are De-caf Lattes (Fluoride in Coffee AND Water) at a certain bakery, they gave me Down-Cycles I think 3 times in total, at first I wasn’t totally sure that was the source, but I confirmed it without a doubt on 3rd exposure, and no longer go there and go somewhere else where I never have a problem.

      My down-cycles, probably at least 12 in total by now, where at least 7 were induced on purpose to chelate the toxins out of my body, did get weaker and weaker each time they happened, which to me signals I was leaching this junk out, however 12 months later it is still not all gone, and I chalk that up largely due to showering in Fluoridated water every single day, which keeps my Fluorine levels at a minor toxicity level quite obviously, I mean if a little dab of Fluoride toothpaste can set things off and start causing the leaching of Magnesium from the cells again etc etc (the one thing that really shuts the twitching “off” for me) then obviously I still have some toxicity.

      Anyway its just one more confirmation for anyone who still has doubts, ALL sources of Fluorine, which includes Fluorides, are an issue for someone who has crossed their threshold.

    • Jason May 10, 2016 at 10:13 pm Reply

      http://www.naturalnews.com/053953_fluoride_cancer_water_safety.html

      Undeniable evidence from numerous studies proves that fluoride causes cancer

      • Jason May 10, 2016 at 10:14 pm Reply

  12. Bob Monday May 3, 2016 at 6:17 pm Reply

    8 1/2 year floxie here. Fibromyalgia symptoms and tinnitus, with fatigue ect. This has me convinced that I need a whole house system for deflorination of the water. Anyone put in a whole house system that they recommend?

    • Bob Monday May 3, 2016 at 6:18 pm Reply

      Forgot to hit the email me comments.

  13. Mark Stark July 15, 2016 at 6:19 pm Reply

    Effect of tamarind ingestion on fluoride excretion in humans.
    http://www.ncbi.nlm.nih.gov/pubmed/11840184

  14. Jason August 11, 2016 at 1:31 am Reply
  15. Jenny October 1, 2016 at 9:38 pm Reply

    Have any of you other floxies out there tried doing an iodine loading type detox? I’ve come across this on the internet and wondering if it helps clear the quiniolone toxicity symptoms? All you need is Lugol’s iodine. I’m new to this recovery process only after finally figuring out the cause this last year. I have severe muscle jerking when trying to go to sleep, so I’ve never been able to recover after dealing with this for over 8 years after a 5 week poisoning back in 2008. It has destroyed my sleep and therefore my regenerating/healing process. All my connective tissue is trashed. I suspect this jerking is due to the flouride toxicity but I’m still not sure if its a magnesium problem. I’m unable to tolerate magnesium due to it causing diarrhea. Even transdermal magnesium gives me the runs sometimes. I’m still working on systemic candida issues after years of supplements, so could this be my problem with magnesium? I read the ebook “The Fluoroquinolone Toxicity Solution”. unfortunately I’ve already tried all the supplements she recommends. Her book doesn’t even address the flouride issue, which in my research is undoubtedly part of the problem. Any help is appreciated. I was floxed at age 26. I’m now 35. my life has been ruined by this and I’m still grasping at straws. My nervous system is badly damaged.

  16. Thomas Shamp July 9, 2017 at 12:31 am Reply

    Given that people who take non-fluoridated quinolones can also be floxxed id say its quinolone toxicity. However, fluoride dose enable the quinolone structure to more easily penetrate lipid membranes like the bbb.

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