Sick Friend, Sick Family, Sick World

This post is going to be a bunch of things that I’ve been thinking about. There isn’t necessarily a theme or connection between any of them, but they are things that I want to share, and even discuss (feel free to comment below), with the floxie community.

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First, Henk. Henk Noordhuizen has been contributing to the floxie hope community through his comments on the site (primarily the home page) for several years. He has provided information, insight, support, advice, humor, and friendship to the community through the years that he has been floxed. He is appreciated and adored by many. Sadly, Henk has recently been diagnosed with cancer of the esophagus. He is very weak and his prognosis is poor. I’m so sad about his illness, and I know that many others are too. Henk is in my thoughts, and I wanted to let others in the floxie community know what is going on with him so that they/you can send healing thoughts (and prayers if so inclined). If any of you want me to forward messages to Henk, please send them to me through the Contact link above, and I will send them to Henk. Thank you. And, Henk, if you read this, know that we are thinking of you. Hugs!

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Next, some COVID-19 stuff. I don’t know any more about COVID-19, or what to do about it, than anyone else, so I’ll keep my thoughts and opinions brief.

It’s bizarre that use of hydroxychloroquine for treatment of COVID-19 has become a politicized and polarizing issue. I suppose that it’s because Trump mentioned it, so now support or opposition of use of hydroxychloroquine is an indicator for whether a person supports or opposes Trump. This whole line of thinking, on both sides, is nonsense. It’s a drug. It has effects, and it has side-effects. With proper studies and experiments it will either be shown to be a safe and effective treatment for COVID-19, or it won’t. Randomized double blind studies have not yet been performed though, so we honestly don’t know how safe or effective hydroxychloroquine is for COVID-19 patients. I’m sure we’ll know with time whether or not it is considered a safe and effective treatment for most people (though not all people – some will suffer from adverse reactions that may be awful). Hydroxychloroquine has been around for a while, and we do know that it has some serious “side effects” (I really hate that term because it doesn’t encompass the horror of adverse drug reactions) that are worrisome. It is also chemically similar enough to fluoroquinolones that I think it’s appropriate for the “floxie” community to be cautious and wary of it. As I said in my last post, I would try to avoid it if possible, but that’s just me. I also think that it’s ridiculous to be either for or against hydroxychloroquine as a potential treatment for COVID-19 based on politics, and I’m glad that Trump has never said a thing about fluoroquinolones.

A lot of people who get COVID-19 are going to join the unfortunate “club” of those who are chronically ill, and it is likely that many of them will also join the unfortunate “club” of those who have been hurt by pharmaceuticals. Unfortunately, there are going to be some COVID-19 victims who are also floxies because, sadly, co-infections are being treated with fluoroquinolones. It’s all sad and scary and I’m not sure what else to say about it other than to point out the obvious that YOU DON’T TREAT VIRUSES WITH ANTIBIOTICS.

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On another, personal, topic – my Dad had a pacemaker put in about 10 days ago. The electrical system for his heart stopped working entirely, and we are all lucky that his backup system kicked in (apparently some people don’t have a backup system, or it doesn’t kick in), and that he had an appointment with a cardiologist when he did. The cardiologist said that people who have a heartbeat that is as slow and erratic as my Dad’s was usually come into the ER on a stretcher. As soon as my Dad got to the cardiologist’s office, he was told that he’d have to have a pacemaker put in ASAP. They did so that day, and he is now doing well. The pacemaker saved his life – the doctors who diagnosed him and put in the pacemaker did too – as did the entire medical system that made his surgery possible. This is the second time that medical interventions have saved my Dad’s life. The first time was about 15 years ago when he had cancer (non-hodgkin’s lymphoma) and a single round of chemo kicked it. We have been lucky and grateful twice.

It’s hard to be angry with the medical system when it saved my Dad’s life twice – once very recently. I’m grateful that pacemakers exist, that the surgery is so remarkably uninvasive, and that he is doing well. This in no way negates that I wish that the medical system was better at acknowledging, treating, and even curing multi-symptom chronic illnesses – especially those caused by pharmaceuticals. I don’t want to throw the baby out with the bathwater as they say, but I do want the bad drugs, and bad doctors, and bad practices, and bad studies, to be abandoned as they deserve. I think, and hope, that there’s room for both embracing the good and criticizing and abandoning the bad. I hope that our collective criticism of the medical system makes it better. It needs to get better – it is hurting too many people. But it also saves people, and right now, I am grateful that my Dad’s life was saved and that he is doing amazingly well.

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Fluoroquinolone Toxicity Featured on The Doctors

After years of multiple people writing, tweeting, and otherwise advocating for fluoroquinolone toxicity to be featured on the show, The Doctors, it finally happened. Whoo hoo!

In the April 2020 episode of The Doctors that goes over fluoroquinolone toxicity, one of the host doctors, Dr. Ordon, discusses his journey through getting “floxed”. Dr. Ordon took a fluoroquinolone to treat chronic prostatitis. It should be noted that most cases of chronic prostatitis are NOT bacterial, and that fluoroquinolone antibiotics are no better than a placebo at treating non-bacterial prostatitis (https://floxiehope.com/2015/04/15/cipro-is-no-better-than-a-placebo-at-treating-chronic-prostatitis-chronic-pelvic-pain-syndrome/). Unfortunately, Dr. Ordon had an adverse reaction to the fluoroquinolones he took. Dr. Ordon’s symptoms of fluoroquinolone toxicity that were discussed on the show include achilles tendinitis and muscle atrophy.

Dr. Ordon was helped by Dr. Mark Ghalili of Regenerative Medicine LA. On the show, Dr. Ghalili discusses some of the treatments he prescribed for Dr. Ordon including a customized IV treatment and growth factor injections.

Dr. Ghalili also discusses his journey through fluoroquinolone toxicity. Dr. Ghalili was in a wheelchair and unable to care for himself for months after taking a fluoroquinolone. He also suffered from brain fog and other adverse effects. You can learn more about his journey on Episode 25 of The Floxie Hope Podcast.

In addition to the help that Dr. Ordon received from the treatments provided by Dr. Ghalili, the host doctors also discussed the importance of time and patience for Dr. Ordon to get through fluoroquinolone toxicity.

This episode of The Doctors will certainly bring fluoroquinolone toxicity awareness to the thousands of people who watch the show. All those that made the episode possible are greatly appreciated!

You can view the fluoroquinolone toxicity feature on The Doctors here:

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Floxed in the time of COVID-19

The world has shifted. Most of us started the year as if 2020 was going to be a continuation of the norm of 2019, but the world shook, and all assumptions are now out the door.

We are dealing with a global pandemic. COVID-19, the novel coronavirus, has reached every state in the U.S. and most nations in the world. It has killed thousands of people, and it will almost certainly kill thousands more.

Governments have reacted to COVID-19 by declaring national (or local) emergencies, closing borders, stopping travel, shutting down places where people gather (including restaurants, bars, beaches, churches, etc.), closing schools, locking down nursing homes and retirement communities, telling people to stay home from work, and more. These actions have enormous consequences for our economy, and the reach of the ripple-effects are, and will be, far and wide.

I worry about my community—Durango, Colorado. I worry about the virus reaching Durango. As I write this, no cases have been confirmed in my community – but I’m sure that the day is coming when someone in the community will have, and spread, the virus. I worry about the pain, suffering, and death that will bring. I also worry about the effects of the reactions to COVID-19 on my community. I worry about all the people with young kids who can’t go to school for the next month who now must choose between their job(s) and leaving their kids at home alone. I worry about the people who can barely make ends meet while working full-time who are getting their hours cut because we won’t get tourists this year. I worry about the medical workers who must be exposed to sick people as part of their jobs.

I worry about the floxie community and my floxed friends as well. Floxies are susceptible to viruses just like anyone else, and they are also affected by economic fluctuations. Most of my floxed friends have been hurt economically by fluoroquinolones – losing jobs, money, marriages, relationships, and much more because of fluoroquinolone toxicity – and being further economically hurt by COVID-19 is likely to push some of them over the edge.

I worry about many things and many people.

All this fretting. I wish it was helpful, but, alas, it isn’t. But perhaps it may be helpful for someone reading this to hear that someone else cares and is worried about them. People care enough to worry – I do.

I don’t know any more about the ever-changing COVID-19 virus situation than anyone else. However, I do have a few thoughts on how it might affect those who have been floxed. As always, please keep in mind that I’m not a doctor and these are not opinions that are informed by any medical education, they are simply my opinions and thoughts. Here they are:

  1. If you are not on immunosuppressive drugs, I don’t think that COVID-19 will be any more dangerous for you than it is for anyone else. Yes, I know that fluoroquinolone toxicity makes your immune system go haywire, and that fluoroquinolone toxicity looks and feels a lot like various autoimmune diseases. But, I believe that what makes people with autoimmune diseases more susceptible to infections is the immunosuppressive drugs they are often on, not the autoimmune disease itself. HOWEVER, when COVID-19 (and ebola, and a lot of other viral infections) kills people, it is by over-reaction of the immune system in a process called a cytokine storm. So, if floxies have an over-reactive immune system they may be more likely to experience a cytokine storm. I haven’t seen any research saying that floxies are any more likely to experience a cytokine storm than anyone else though, and I assume that floxies are no more, or less, likely to be infected with or experience complications from COVID-19 than anyone else.
  2. Apparently, people who survived SARS and MERS often experience severe ongoing chronic fatigue after they recover. COVID-19 is related to both SARS and MERS, though whether or not there are ongoing fatigue-related effects of COVID-19 is still to-be-determined. A lot of floxies experience severe and intractable fatigue, and even though my fatigue wasn’t near as bad as that of many people, the thought of virus-induced chronic fatigue scares the crap out of me.
  3. NSAIDs can make COVID-19 infections worse. NSAIDs suck. Here are a couple articles about NSAIDs and COVID-19 as well as a couple posts about how NSAIDs are bad for floxies.
    1. The Guardian, “Anti-inflammatories may aggravate Covid-19, France advises
    2. Floxie Hope, “Why NSAIDs Suck for Floxies (and Probably Everyone Else Too)
    3. Floxie Hope, “NSAIDs and FQs Damage Mitochondria, Increase Oxidative Stress, and Cause Cell Death
  4. Chloroquine is being explored as a potential treatment for COVID-19. It is related to fluoroquinolones, but it is NOT a fluoroquinolone. It’s more of a cousin, or even second-cousin, drug. Is chloroquine contraindicated for people who have been floxed? Probably…. But I have not seen any studies showing that. Still, the precautionary principle should rule in most circumstances, and I wouldn’t touch it. In addition to its quin structure, problems with chloroquine include:
    1. It can cause retinal toxicity and blindness.
    2. Both chloroquine and ciprofloxacin are lysosomotropic drugs. People who are smarter than me should read “Lysosomal cell death at a glance” to figure out what that means.
    3. Chloroquine inhibits thiamine uptake, and depleted thiamine is related to many chronic illnesses (you can read about the connections between thiamine, mitochondrial health, and chronic illness on hormonesmatter.com).
    4. Both fluoroquinolones and chloroquine can lead to serious cardiac problems, including arrhythmia and cardiomyopathy, both of which can lead to death.
    5. Both fluoroquinolones and chloroquine can cause tinnitus, and tinnitus can be miserable.

As I said, I wouldn’t take it if it was avoidable. (I am not under the impression that people quarantined in a hospital have much liberty or choice over what drugs go into their bodies though, and I doubt I would be able to make that decision if faced with treating COVID-19 – hopefully I am being pessimistic on that front and body autonomy isn’t actually relinquished when in the hospital…. But I still hope to never be in the situation to find out.) Chloroquine is a serious and consequential drug that may be particularly consequential for people with a history of adverse reactions to fluoroquinolones, but, I want to caution against a total knee-jerk reaction against any drug or substance with “quin” in its name. For example, pyrroloquinoline quinone (PQQ) is a mitochondrial support supplement that many floxies have tried without incident – and its name is even scarier than chloroquine. My approach to chloroquine is to avoid it until it is proven safe for floxies, and hope that it won’t be forced upon me. I’m not a doctor and my approach may not work for others, but it’s my two cents for anyone who wants my thoughts on the matter.

We are still at the early stages of the COVID-19 pandemic, and I have no clue what the future will hold. I hope that the pain and suffering brought on by this disease is minimized as much as possible. I hope that the floxed community emerges from this difficult time without too many additional scars.

Hugs,

Lisa

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Fluoroquinolone Toxicity Studies

A couple fluoroquinolone toxicity studies are being conducted.

Dr. Charles Bennett, a Professor at the University of South Carolina College of Pharmacy, is conducting a study of genes related to fluoroquinolone toxicity. Dr. Bennett is seeking “floxed” participants in the study. In the “Floxed Friday” newsletter sent out by Michelle Polacinski – Floxie, Director, and Producer of ‘Floxed’ – the following information about how to participate was shared:

This study is open to those who have experienced FQ Toxicity. If you are interested in participating, please send your contact information (name, address, phone #) to abc8@email.sc.edu and please write “FQ Study” in the subject line.

You will receive instructions, a consent form, and a survey to complete. A saliva test kit will then be mailed to you. You will provide your saliva sample, as instructed. Then, you will mail the sample back to the university, as instructed.

This is very exciting! This study has the potential to answer questions about who is predisposed toward fluoroquinolone toxicity, and, as genetic testing gets easier and easier, perhaps it will someday lead to screening tools that will keep doctors from prescribing fluoroquinolones to people who are genetically predisposed toward fluoroquinolone toxicity.

I encourage you all to participate in the study. (FYI – just my personal experience – I emailed my information to the email address provided twice, but have not yet heard back from anyone, so I don’t have any personal experience of this study. I just have heard about it and I’m passing on the information I heard.)

Another study of fluoroquinolones is being conducted by the Mayo Clinic (the branch in Rochester, Minnesota). It is a clinical trial entitled, “A Study to Evaluate Biomarkers of Fluoroquinolone-induced Mitochondrial Toxicity” and more information about it can be found on the Mayo Clinic web page about the study.

Per the clinical trial announcement:

“The purposes of this study are to determine if patients treated with fluoroquinolone (FQ) antibiotics have depletion of mitochondrial DNA (mtDNA) in buccal swab samples, and whether the degree of depletion correlates with the likelihood of developing FQ-associated toxicity.”

This is a very exciting study for the floxed community in a couple ways. First, it is to determine whether or not mtDNA is depleted in humans. Several studies have shown that fluoroquinolones deplete mtDNA in cells studied in labs, but I don’t believe that any studies have shown the depletion of mtDNA in people.

The study requires recent administration of a fluoroquinolone antibiotic (the inclusion criteria includes, “Treatment with oral and/or intravenous FQ antibiotics (ciprofloxacin, levofloxacin, moxifloxacin, delafloxacin) that has been initiated upon, or within 24 hours of, admission to the HIM service or at time of initial Infectious Diseases consultation and lasting > 48 hours.“) so I don’t recommend that any floxed people sign up for it. Some people have expressed dismay over fluoroquinolones being studied by being given to people, and, while I understand the misgivings, fluoroquinolones are given to people all the time and I feel encouraged that there are people who are studying the effects of fluoroquinolones, even if the study requires administering them. I am assuming that the people who are a part of the study will be in-need of antibiotics and that fluoroquinolones would be given to them regardless of whether or not they participate in the study – I at least hope so, because giving these drugs to people who don’t have an infection or other need for them is unethical.

I appreciate the acknowledgement that is implicit in both these studies. In studying both genetic markers and mtDNA depletion as they relate to fluoroquinolone toxicity, fluoroquinolone toxicity is being acknowledged by the scientists and doctors conducting the studies. Acknowledgement is helpful in that it leads to studies which lead to more information which lead to fewer people getting hurt by fluoroquinolones and/or maybe even a cure for fluoroquinolone toxicity. We can at least hope for those things.

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Are Damaged Mitochondria Causing Autoimmune Diseases?

Fluoroquinolone toxicity looks and feels a lot like multiple autoimmune diseases including rheumatoid arthritis, lupus, MS, thyroid autoimmune diseases, and others. Some people have proposed that fluoroquinolone toxicity is its own autoimmune disease, but the auto-antibodies have not yet been identified and thus it is not treated as an independent autoimmune disease. In some people, fluoroquinolones have triggered a recognized autoimmune disease, as you can read about in Michelle’s Story of fluoroquinolone-induced lupus, JMR’s story of fluoroquinolone-induced thyroid autoimmune diseases, and I know a couple people with fluoroquinolone-induced MS.

I have always wondered what the connections are between fluoroquinolone toxicity and autoimmune diseases, whether or not fluoroquinolones are truly triggering autoimmune diseases generally, and what the mechanism is behind the connection.

A recent article in Scientific American, Brain’s Dumped DNA May Lead to Stress, Depression: New research suggests genetic material from the mitochondria can trigger an immune response throughout the body provides some interesting connections (and, dare I say, answers). The article points out that mitochondrial DNA, when it is released from mitochondria, can cause inflammation and an immune response:

“But how was this inflammation triggered by mitochondrial DNA leaking out of cells? A 2010 Nature paper provided the answer: In it researchers demonstrated the way mitochondrial DNA, when released into the blood after an injury, mobilized a pro-inflammatory immune response. Because of mitochondria’s bacterial origin and its circular DNA structure, immune cells think it’s a foreign invader.  When circulating mitochondrial DNA binds to a particular receptor, TLR9, on immune cells, they respond as if they were reacting to a foreign invader such as a flu virus or an infected wound. The immune cells release chemicals called cytokines telling other white blood cells they need to report for duty at sites of infection, inflammation or trauma.”

Multiple studies have shown that fluoroquinolones disrupt the replication and reproduction cycles of mitochondrial DNA (mtDNA) and deplete mtDNA. Of course they do – mitochondria are descendants of bacteria and drugs that affect bacterial DNA have similar effects on mtDNA. The way that fluoroquinolones work is that they disrupt the DNA and RNA replication cycles for bacteria (and mitochondria).

When mitochondrial DNA is released via fluoroquinolones (or a variety of other pharmaceuticals and environmental toxins that also damage mitochondria) the immune system attacks it because it appears to the immune system to be bacterial DNA. This attack of loose mtDNA can lead to an immune-system over-response, and even trigger an autoimmune disease.

The Scientific American article also notes that:

“The genetic cast-offs are not just inert cellular waste. “This circulating mitochondrial DNA acts like a hormone,” says Martin Picard, a psychobiologist at Columbia University, who has been studying mitochondrial behavior and the cell-free mitochondrial DNA for the better part of the last decade. Ejection of mitochondrial DNA from the cell mimics somewhat adrenal glands’ release of cortisol in response to stress, he says. Certain cells produce the circulating mitochondrial DNA and, as with the adrenal glands, its release is also triggered by stress.”

To emphasize – “circulating mitochondrial DNA acts like a hormone” that “mimics somewhat adrenal glands’ release of cortisol in response to stress.” So many people suffering from fluoroquinolone toxicity are in vicious cycles of chronic stress and anxiety that are wreaking further havoc on their health. The post, “Cellular Stress, Chronic Stress, and Fluoroquinolone Toxicity” goes into more detail about the connections between stress and anxiety and fluoroquinolone toxicity.

Fluoroquinolones aren’t the only toxins that damage mtDNA. The list of pharmaceuticals that damage mtDNA include all bactericidal antibiotics (including fluoroquinolones) (1), statins (2), chemotherapy drugs (3), acetaminophen (4), metformin (a diabetes drug) (5), and others. The environmental pollutants that have been shown to damage mitochondria include rotenone, cyanide, lipopolysaccharide, PAH quinones, arsenic, and many others (6).

I would bet quite a bit that the rise in autoimmune diseases corresponds with the rise in production of pharmaceuticals, pesticides, herbicides, and other chemicals that are toxic to mitochondria. The Scientific American article, Brain’s Dumped DNA May Lead to Stress, Depression: New research suggests genetic material from the mitochondria can trigger an immune response throughout the body, provides some valuable connections that point in that direction, and I would love to see more research on the topic.

 

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Patience and Kindness

Perhaps it’s because of the winter solstice dark and cold, or because 2019 was a particularly bad year for some people, or because being floxed SUCKS, or because of fear, or because nuance can be difficult to convey via the internet, or because of a million other potential reasons for ill moods, but it seems to me that people have been particularly impatient, rude, and even hateful on the floxie facebook pages and groups–including the floxie hope page and the fluoroquinolone wall of pain page, both of which I manage. I’m pretty decent at ignoring unpleasant things and avoiding confrontation, but the comments that are mean-spirited are starting to bother me. Perhaps in recognition of the holiday spirit or the change of the year (and decade), I would like to make a request – can y’all please be nice?

No one knows the perfect way to go through fluoroquinolone toxicity. No one knows the correct way to cure this. Everyone is experimenting and trying their best. Some people try things that they hope will be helpful or curative that have hurt others. The people who try these things are not stupid or trying to rub an adverse reaction in anyone else’s face. Sometimes knowledge of best practices shifts and what someone tried years ago is now known to hurt floxies. It stinks, but it happens. There’s no need to belittle people for what they tried years ago – or what they tried yesterday. People are doing their best to heal with the information they have. Feel free to give more information, but I would like to ask people to please be thoughtful when “correcting” others.

A common criticism on the floxie hope facebook page is that posts are old. Yup – some of them are. This site has been around for 6.5 years – since June, 2013. I put older posts up on the floxie hope facebook page because I figure that some people will still get value out of the posts. I sincerely hope that they are helpful, hopeful, or otherwise valuable to some of the people who see them. I also don’t think that 6 years is that long, or that a 6-year-old post is less valuable than a 6-hour-old post. However, if some of the information is out-dated or incorrect, I apologize. I did the best I could at the time I wrote each post, and I’m still doing my best now. I try to post accurate and backed-up information, but sometimes I’m wrong about an assertion. It happens. I’m a blogger. This site is my blog, not a peer-reviewed journal. I have always tried my best to be correct, but I don’t have the resources to verify any of my assertions about the causes or effects of fluoroquinolone, so please take everything I write with that grain of salt.

I also put up old posts because, frankly, I’ve gotten tired of doing fluoroquinolone research, putting together pieces of information from various sources, and formulating thoughtful and informative posts. I don’t have the emotional or intellectual energy to do that like I used to. I apologize. I wish I still had that energy and passion. But, to be honest, it has waned. I miss the passion that I once had, and I feel like the posts I have written in the last year-ish are not particularly inspired (or interesting). I would LOVE to have thought-provoking, interesting, inspired, passionate posts on this site, and I invite anyone who is interested in putting a post on floxiehope.com to send me what they’d like to post. This site has a decent-sized audience and it’s a good way to say what you want to say about fluoroquiolone toxicity to the community. Please let me know if you’re interested in writing for floxiehope.com (through either clicking THIS LINK or on the pic below).

One more thing that is a bit tangential – Facebook is cracking down on a lot of sites and groups, and I hope that the fluoroquinolone toxicity community on Facebook doesn’t get hurt by the crackdowns. I don’t think I’m breaking any FB rules, but even without thinking I’m breaking any rules, I’m still having some issues. This notice is currently on the fluoroquinolone wall of pain facebook admin page:

I clicked on the “learn more” link and, as far as I can tell, all rules have been followed. But maybe I did something inadvertently that was against facebook’s rules. Or, maybe they’re wrong. Either way, facebook has a massive amount of power to affect our reach and our ability to spread the word about fluoroquinolone toxicity, and if they shut down the pages and groups related to fluoroquinolone toxicity, well, that will be an awful shame. Facebook has facilitated the growth of this community (as I’m writing this, the Fluoroquinolone Toxicity Group on Facebook has 10,761 members). It has facilitated people sharing information about this illness, recovery, coping, etc. I am grateful to Facebook for all that it has offered. But what it gives, it can take away. I’m slightly worried that a wrong move can result in the disillusion of a major meeting-ground for floxies. I hope that we can continue to use facebook, and it would be a shame if we couldn’t and had to start over on a different platform. If you have a problem with something that is posted on the floxie hope facebook page or the fluoroquinolone wall of pain facebook page, please contact me rather than reporting it to facebook. Maybe then we can stay in their good graces.

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Mitochondria Summit

I just had surgery (just a couple hours ago as I write this), so this post is going to be short and sparse. BUT, I wanted to let you all know that there is a summit about Mitochondria that is happening THIS WEEK (December 9-15). You can access it through clicking on the image above, or through THIS LINK.

Fluoroquinolones damage mitochondria, and have been shown to deplete mitochondrial DNA. More information about the damage done to mitochondria (the energy-producing organelles of our cells) can be found in these posts:

Study Finds that Ciprofloxacin Depletes Mitochondrial DNA

New Study Finds that Ciprofloxacin Depletes Mitochondrial DNA

More posts about how fluoroquinolones damage mitochondria can be found through doing a search for mitochondria on floxiehope.com, and through searching for “mitochondria” on the links & resources page where you can find media and journal articles about the effects of fluoroquinolones on mitochondria.

In their April 27, 2013 Pharmacovigilance Review, “Disabling Peripheral Neuropathy Associated with Systemic Fluoroquinolone Exposure,” the FDA describes the damage done to mitochondria by fluoroquinolones:

Ciprofloxacin has been found to affect mammalian topoisomerase II, especially in mitochondria. In vitro studies in drug-treated mammalian cells found that nalidixic acid and ciprofloxacin cause a loss of motichondrial DNA (mtDNA), resulting in a decrease of mitochondrial respiration and an arrest in cell growth. Further analysis found protein-linked double-stranded DNA breaks in the mtDNA from ciprofloxacin-treated cells, suggesting that ciprofloxacin was targeting topoisomerase II activity in the mitochondria.

The FDA Pharmacovigilance Report also notes that mitochondrial damage (and the ensuing oxidative stress that occurs when mitochondria are damaged) is related to multi-symptom, chronic diseases like optic neuropathy, neuropathic pain, hearing loss, muscle weakness, cardiomyopathy, lactic acidosis, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis (ALS).

I am excited to hear what the mitochondria experts featured in the Summit have to say about healing mitochondria, possibly un-doing the damage done by fluoroquinolones, and maybe even how to prevent the diseases associated with damaged and depleted mitochondria.

One of the featured speakers is Dr. Terry Wahls, author of The Wahls Protocol, that has helped many floxies including Renee and Jamieson. You can read Renee’s story HERE and you can listen to her podcast HERE and you can read Jamieson’s story HERE. Dr. Wahls was also featured on The Floxie Hope Podcast and you can listen to her interview HERE.

I’m also excited to hear Bridgit Danner, LAc, FDNP discuss the effects of toxic mold on mitochondria, and to hear Michelle Sands, ND discuss the hormone-mitochondria connection, and to hear Jason Prall discuss microbiota-mitochondria communication, and to hear what many more wonderful speakers have to say about mitochondria.

I look forward to spending the next couple days relaxing, recuperating, and recovering from my surgery while learning lots about mitochondria.

I think it will be helpful for floxies, and give insight into healing our mitochondria. It’s THIS WEEK – please let me know your thoughts in the comments below. We can all learn together. 🙂