Monthly Archives: May 2014

Epigenetics and Fluoroquinolones: Now What?

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Per Dr. Chandler Marrs (who runs www.hormonesmatter.com), “Above and around genetic codes reside the on/off switches to many processes (the switching of genes on and off is epigenetics). If common medications, including fluoroquinolones, up or downregulate these processes and create new diseases, what is someone who takes them supposed to do? Can epigenetic changes be reversed? What is the patient to do with all the recent research on epigenetics? The research is all well and good, but what does it mean to the patient?”

Indeed.

Here is a post about how fluoroquinolones, and other common pharmaceuticals, affect epigenetics. There are currently more questions than answers and the right path is far from clear.

https://www.hormonesmatter.com/epigenetics-common-medications/

 

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Articles About Fluoroquinolone Toxicity to Give to Your Doctor

People often ask for articles about fluoroquinolone toxicity to share with their doctors.  Following are a few articles that I recommend.

What you should share with your doctor depends on your doctor’s willingness to read what you give him or her.  Doctors are busy.  Most of them don’t have the time, energy or inclination to keep up with all of the latest drug research.  They depend on the FDA to regulate drugs and they assume that if a drug has been on the market for years, it must be safe.  They are wrong in those assumptions.  It would be more appropriate for them to assume that all of the mysterious diseases of modernity (fibromyalgia, chronic fatigue syndrome / M.E., autoimmune diseases, allergies, dietary intolerances, autism, etc.) are due to the damage that pharmaceuticals are doing to the mitochondria, microbiome, endocrine system, etc.; and the feedback loops between those delicate systems.  Unfortunately, most doctors haven’t had that epiphany quite yet.  Here are some articles that can at least introduce Fluoroquinolone Toxicity Syndrome to them:

Show your doctor this if 4 sentences is his/her limit:

I’m going to ruffle feathers, but I’ll tell you anyway” By Suzy Cohen

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Here are more details on fluoroquinolones being chemo drugs, as Suzy Cohen notes: “ CIPRO, LEVAQUIN AND AVELOX ARE CHEMO DRUGS” by me (Lisa Bloomquist) on Hormones Matter.

For doctors who are willing to take the time to read a few articles, but aren’t going to spend a lot of time looking into FQ toxicity, I recommend that you show them these:

  1.  Dear Doctor letter written by Dr. Plumb, a doctor who was Floxed
  2. New York Times article by Jane Brody, “Popular Antibiotics May Carry Serious Side Effects
  3. PBS Frontline expose about fluoroquinolones
  4. Forbes article by Melanie Haiken, “Antibiotic Alert: The Drug the Doctor Ordered Could Cause Deadly Side Effects
  5. Fluoroquinolones 101” by me (Lisa Bloomquist) on Hormones Matter.

For doctors who are willing to read journal articles about fluoroquinolones, I recommend these:

  1. Physical Medicine and Rehabilitation (PM & R) “Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population
  2. Science Translational Medicine, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
  3. Journal of Young Pharmacists, “Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients
  4. Molecular Pharmacology, “Delayed Cytotocicity and Cleavage of Mitochondrial DNA in Ciprofloxacin Treated Mammalian Cells

There are more than 100 other useful peer-reviewed research articles on the Links & Resources page of Floxie Hope.

Another thing that you can do is go over the FDA warning labels for the fluoroquinolones with your doctor:

  1. FDA Datasheet – Ciprofloxacin (Cipro)
  2. FDA Datasheet – Levofloxacin (Levaquin)
  3. FDA Datasheet – Moxifloxacin (Avelox)

The severity of adverse reactions to fluoroquinolones isn’t noted anywhere on the labels.  Nor is the fact that symptoms can be delayed.  It is assumed, by everyone, that adverse drug reactions are transient and that they will stop when administration of the drug has stopped.  This isn’t true for fluoroquinolones.  The adverse effects listed on the fluoroquinolone warning labels are multi-systemic and perhaps your doctor should wonder how and why fluoroquinolones cause multi-symptom, chronic illness.

Most people, doctors and patients alike, think that adverse reactions to fluoroquinolones are rare.  If you feel like going over this post with your doctor, I think that I make some good points in it:  “Is Fluoroquinolone Toxicity Rare?

Multi-symptom chronic illness brought on by a chemotherapy drug masquerading as an antibiotic is something to take seriously.  If your concerns are not taken seriously, I highly recommend finding another doctor.

And please thank the doctors who listen to you, read the articles that you give them and start being more prudent with their use of fluoroquinolones.  When a critical mass of doctors realize the dangers of these drugs, we’ll start seeing change.  I thank every one of you who takes the time to talk to your doctors about fluoroquinolone toxicity.  It does a lot of good.

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Thanks for the Fluoroquinolone Toxicity Rally!

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The second annual Fluoroquinolone Toxicity Awareness Rally occurred on May 8th and 9th, 2014. A group of people went to Washington D.C. to stand up and say, “I was poisoned by a fluoroquinolone antibiotic and IT IS NOT OKAY.” We gave that message to our congressional representatives and anyone else who would listen. People listened. They heard what we had to say and they responded with empathy and compassion. Many people shared their own stories of harm done to them by fluoroquinolones with us. We connected with people. We warned people. We tried to make a step toward changing this absurd situation of a chronic, multi-symptom illness being induced by taking an overly strong prescription antibiotic.

So many people made the rally possible that I cannot possibly list them all individually, so I will list them categorically.

Thank you to the people who organized the rally. A huge amount of work was put into organizing meetings, hotels, presentation materials, transportation, permits for the demonstration, the materials given to the congressional representatives that we met with, etc.

One of the materials presented to the congressional representatives was a book of stories of pain and suffering inflicted by fluoroquinolones. Thank you to all of the people who took the time to write their stories, and thank you to the people who organized and edited the book. A lot of hard work went into the book and it is appreciated!

Presentations were given and I am thankful to all of the people who put work into making the presentations possible. The analysis, synthesis, logistics, presentation, etc. all took time and energy and I appreciate everyone who helped with them.

Thank you to everyone who attended the rally! People flew to D.C. from all over the country and one person even came in from Canada. People who are sick spent their time, money and energy to get to D.C. in order to advocate. All of you – your efforts are greatly appreciated!

Thank you to all of the people who met with Floxies. Senators, Representatives, their aides and interns all took the time to meet with us and listen to our stories. I am grateful for their time and attention.

Thank you to the people who listened to us and engaged with us as we handed them FQ Toxicity Awareness cards as they walked by. Your openness and receptiveness are appreciated!

Everyone who was involved in the rally, either directly or indirectly, made it possible and I greatly appreciate all their efforts.

A lot of hard work went into the rally. Whether it results in change is still to be determined. Whether or not the rally was a success is to be determined – assuming that you base success on outputs (change) not inputs (time, money, effort spent).

In order for change to come about, the ball has to start rolling somewhere. All of the effort that was put into the rally may result in change. I hope so. It certainly resulted in some lessons learned. We will get more and more effective as time goes on. Maybe someday legislation will be enacted that stops this absurd situation from occurring. I hope that the ball is rolling in that direction.

Thank you for reading Floxie Hope!  I hope that all who read Floxie Hope gain insight, support, understanding and, most of all, HOPE.  If you would like to support Floxie Hope, all contributions will be greatly appreciated!  Click HERE to contribute to Floxie Hope.  Thank you!

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Losing my Reading Comprehension

I lost a lot of my reading comprehension while I was floxed. I could still officially read – if you gave me a short memo that said, “buy milk,” or something like that, I could read it. But reading a novel or complex materials for work became really difficult. I lost track of the content of the beginning of a paragraph by the time I reached the end of the paragraph. I struggled to understand things that I used to be able to read with ease. I read The Hunger Games series about 2 months after I got floxed. Despite the fact that most 14-year-olds are able to understand those books, and I could have breezed through them before I got floxed (especially when I was 14), I struggled to comprehend them. I remember the basic gist of the books, but the details were lost on me. I read them slowly and without joy or interest (which kind of sucks because I heard that they were fun). My job requires me to read so I had to force myself to read materials for work, but it was difficult to get through them and I had to read everything two or more times in order to understand what I had read. Even after reading work materials a couple of times, I was still unsure about what I had read.

I hated the feeling of not being able to read like I used to be able to. It was horrible. It was scary. I thought that I was stupid and that I would continue to be stupid because I would never be able to comprehend written words again. I doubted my ability to do my job. I was scared that I wouldn’t be able to learn about what happened to me because I couldn’t read well enough to research. I was scared that I would never be able to enjoy reading a novel again. I was scared that I was unemployable.

Interestingly though, I could still write. My writing actually improved after getting floxed. Written words could flow out of me, but it was a one-way stream – they couldn’t come back in.

I thought of the loss of reading comprehension as a symptom, but it never occurred to me that my improved writing may be a symptom too until other floxies started to report to me that they experienced the same thing – a loss of reading comprehension along with an improved capacity for writing.

Isn’t that odd? Something similar happened in our brains that made us less capable of reading and more capable of writing. It’s really strange and I’m curious about it. What happened? Why would that be a common set of symptoms for multiple people who are suffering from fluoroquinolone toxicity?

Neither a loss of reading comprehension nor an increased capacity for writing are the most severe symptoms that most floxies experience, so I would guess that most people would want research funds to be focused elsewhere. But I wonder if any neurologists find this curious symptom to be interesting enough to study it. If there are any neurologists who read this who want to hear about my experience, please let me know (but know that my willingness to undergo testing is pretty close to zero).

The most simple explanation for these symptoms is that oxidative stress in the brain is what hurt our reading comprehension, and our writing capacity increased because we had something to say. Also, our brains had to compensate in some way for the loss of reading comprehension and perhaps they did so with an increased capacity for writing. That seems like an overly simplified way of looking at complex processes though, and I’m still quite curious about what happened in my floxed brain.

It’s interesting. At least, I think it is. I think that it should be studied. Maybe along with all of the other deleterious effects on the brain/mind that result from fluoroquinolone use.

Are any researchers, scientists or doctors curious about this?

Sadly and strangely, there seems to be a lack of curiosity about anything related to adverse reactions to fluoroquinolones. Maybe that’s because the symptoms are so broad. How does one even start to examine multi-symptom, chronic illness? It’s too big. Perhaps noting some of the little symptoms will pique some curiosity.

I hope so.

P.S. – I can read again. I feel like some of my writing talent has diminished as my reading capacity has increased. This is probably perception more than objective reality, but I wonder if there is only a certain amount of capacity that I have for written words and as one goes up, it takes from the other. Probably not. 🙂

 

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Fluoroquinolones and Children

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The post entitled, “DON’T LET YOUR BABIES GROW UP TO BE FLOXIES” can be found on Hormones Matter.

http://www.hormonesmatter.com/fluoroquinolone-antibiotics-child-health-floxie/

Despite the fact that fluoroquinolone antibiotics – Cipro/Ciprofloxacin, Levaquin/Levofloxacin, Avelox/Moxifloxacin and Floxin/Ofloxacin – are contraindicated in the pediatric population because they have been shown to cause lameness and lesions on the cartilage of juvenile animals, they are administered to children all the time.  I have a friend who has a three year-old daughter who has been prescribed Cipro twice – once in the form of ear drops and once in the form of pills.  Luckily, my friend knows how dangerous fluoroquinolones are and she didn’t fill the prescriptions.  Other parents and children aren’t so lucky.  Children are being hurt by fluoroquinolones every day.  It’s a tragedy that needs to stop.  Please share “DON’T LET YOUR BABIES GROW UP TO BE FLOXIES” with any friends who are parents.  No child should go through the horror of fluoroquinolone toxicity.

 

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