Monthly Archives: December 2014

Off Label FQ Use – WTF are they thinking???

It has come to my attention that (some) doctors are prescribing Cipro to patients who are having adverse reactions to other drugs.

I am so flabbergasted by this that I’m close to speechless.

WHY would anyone think that it is appropriate to give a fluoroquinolone to someone who is experiencing an adverse reaction to a drug?!  NOWHERE in the literature for fluoroquinolones does it say that they should be used to treat adverse drug reactions.  It makes no sense.

I thoroughly disagree with fluoroquinolones being used as antibiotics in cases where there are other, safer, remedies that can be used.  They are too dangerous and it is a violation of the oath to “do no harm” to prescribe fluoroquinolones when there are safer antibiotics available.   But at least fluoroquinolones do kill bacteria.  Most doctors aren’t aware of how dangerous fluoroquinolones are, and they use them for the purposes for which they are indicated – urinary tract infections, prostatitis, sinusitis, typhoid, anthrax, and other bacterial infections.  There are even some articles that indicates that fluoroquinolones can be used as chemotherapeutic agents to kill cancer cells.  But there is NO REASON to think that they should be given to people who are experiencing adverse drug reactions.  It’s insane and it’s dangerous.  What in the world are these doctors thinking?!

Why would any doctor who has taken the Hippocratic Oath prescribe a drug that has a 43 PAGE warning label and a black box warning, for purposes other than those for which it is proven to be effective?  Why would a doctor who has taken a pharmacology class think that it is okay to give a topoisomerase interrupter to someone who doesn’t even have an infection (or cancer – topoisomerase interrupters are really only appropriate for use to treat cancer)?  Why are they ignoring the serious and severe adverse effects that are listed on the warning label?  Why are they handing out Cipro like it is candy?  Why are they giving drugs that deplete liver detoxification enzymes to people who are having an adverse reaction to another drug?  WHY?

Here is a video from a guy (a Veteran) who was given a prescription for Cipro after he went to the VA doctor’s office with an adverse reaction to Finasteride:

Another case is illustrated in this comment, which, frankly, broke my heart:

“The baby reacted badly to each vaccination, screaming throughout the night each time, and the doctor prescribed her cipro drops after each one. She can’t taste, and has many delays in speech, reading, learning, and physical development, even though she started off being very advanced in certain ways.”

WHY?

Why would a child (A CHILD) be given Cipro after she has had an adverse reaction to a vaccine?  To completely shut down her liver?  To shut down her kidneys?  To destroy her mitochondria?  To obliterate her microbiome?  To make sure that the microbial protection that her microbiome should give her blood-brain barrier is completely destroyed and the aluminum in the vaccines gets deep in there? (See post-script for sources.)

What kind of masochistic doctor does that to a child?

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There seems to be a strange and disturbing trend to give people Cipro for no justifiable reason – just ‘cause.  Bayer donated (aren’t they sweet?) 3.7 million Euros worth of Cipro to the countries of West Africa to help them deal with Ebola.  Ummm….. Ebola is a VIRUS.  In case it needs to be said, antibiotics do NOTHING to treat viral infections.  In fact, they can make viral infections worse by killing off the good bacteria in the microbiome that are fighting the virus.  If the doctors in West Africa are giving the people who are fighting Ebola Cipro, they are doing them no good.  Cipro can do plenty of harm too.  The warnings on the 43 page warning label aren’t a joke, and they’re not temporary.

The Western Medicine doctors in West Africa wonder why people don’t trust them and would rather go to a local Shaman.  Shoot, I’d rather go to a Shaman than be needlessly pumped full of Cipro.  The Cipro would definitely kill me, at least I’d have a chance of survival with the Shaman.

We’re in this bizarro world of Orwellian notions of drug safety.  The most dangerous drugs, like fluoroquinolones, are pushed as having “an excellent record of safety and efficacy.”  Just ignore the permanent peripheral neuropathy, severe psychiatric disturbances, mitochondrial dysfunction, cellular mineral chelation, antioxidant depletion, microbiome obliteration, etc. that they cause.  Those symptoms can happen weeks, months, or even years after administration of the drug, so it is pushed that fluoroquinolones are “safe” and that the multi-symptom, chronic illnesses that result from them are a “coincidence.”

Doctors are throwing Cipro at people who they don’t know how to deal with.  If you or your boyfriend/father/son is having bizarre psychiatric problems after taking Finasteride, or your child is reacting badly to a vaccine, they’ll be given Cipro.

Why?

I cannot for the life of me understand why.

Post Script – 

The findings published in Science Translational Medicine in the 2014 article, “The gut microbiota influences blood-brain barrier permeability in mice,” are fascinating and likely quite consequential.  The scientists/researchers found that gut microbiota influences blood brain barrier permeability.  Mice with a compromised (or nonexistent) microbiome showed more permeability in their blood brain barrier than mice with normal/healthy microbiomes.  Blood brain barrier permeability means that unwanted molecules and cells from the bloodstream can enter the brain.  Disturbing our microbiome with antibiotics, especially powerful chemotherapeutic antibiotics like fluoroquinolones, is quite consequential to the brain.

Here are some articles about the study:

Science Translational Medicine, “The gut microbiota influences blood-brain barrier permeability in mice

Translational Microbiome Research Forum, “Gut Microbiota Influences Blood Brain Barrier Permeability

NeuroScienceNews.com, “Gut Microbiota Influences Blood Brain Barrier Permeability

The Scientist, “Mother’s Microbes Protect Baby’s Brain: Bacteria in the gut of a pregnant mouse strengthen the blood-brain barrier of her developing fetus.

Karolinska Institute, “Gut microbiota influences blood-brain barrier permeability

 

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FDA Petitioned to Add Psychiatric Side Effects to Black Box Warning for Fluoroquinolones

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In a survey of 94 people who experienced adverse reactions to Levaquin/levofloxacin, a fluoroquinolone antibiotic, 72% reported experiencing anxiety, 62% reported depression, 48% reported insomnia, 37% reported panic attacks, 33% reported brain fog and/or cognitive impairment, 29% reported depersonalization and/or derealization, 24% reported thoughts of suicide and 22% reported psychosis.

Psychiatric side-effects of fluoroquinolones are common.  Though many of the psychiatric adverse effects of fluoroquinolones are listed on the warning label, they are buried in the “Central Nervous System Effects” section.  Dr. Charles Bennett of the Southern Network on Adverse Reactions (SONAR), has submitted a petition to the FDA requesting that a black box warning about serious psychiatric adverse events be added to the Levaquin/levofloxacin warning label.

More information about the serious psychiatric adverse effects of fluoroquinolones can be found in this post –

PSYCHIATRIC SIDE EFFECTS OF FLUOROQUINOLONE ANTIBIOTICS

Please spread the word about the psychiatric problems that fluoroquinolones can cause.  The serious psychiatric adverse effects of fluoroquinolones are under-recognized.

People are suffering because they are not adequately warned about the dangers of fluoroquinolones.

Thank you for reading and sharing the post!

 

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The Floxie Hope Podcast Episode 001

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With this post, I am officially launching the FLOXIE HOPE PODCAST.

You can listen to the Floxie Hope Podcast through several methods.

First, you can download it from iTunes using THIS LINK.  You can also subscribe to the Floxie Hope Podcast through iTunes.  Please do – and thanks!!

Podcatchers should be able to catch it from iTunes and download it to your phone or other device.

Or, if you prefer, you can stream the podcast directly through your computer by clicking on any of these links:

http://www.floxiehopepodcast.com

Episode 001 of the Floxie Hope Podcast in its own window

If you are interested in being interviewed on the Floxie Hope Podcast, please let me know.  The best way to reach me is through the “Contact” page on this site.

I want to interview people about all things related to fluoroquinolone toxicity.

As you can probably tell from my introductory episode, I’m not completely comfortable on the microphone quite yet.  I’ll get there, I’m sure.  But it would be really nice, and less painful for my listeners, if someone else was conversing with me on the podcast.  I look forward to hearing your stories on the podcast!

Thanks for listening!

 

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Antibiotic Resistance – Can We Please Stop Being Stupid?

Can I just complain about how ridiculously STUPID the over-use of antibiotics in agriculture is?  Antibiotics are regularly used prophylactically in livestock in order to fatten up the animals and to compensate for the abhorrently unsanitary conditions in commercial feedlots.   Neither of those things are okay in the least.  They are appalling in themselves.

But if you don’t care that pigs, cows, chickens and turkeys are dirty and fat, you may say, “so what?”

The “so what” is that pathogenic bacteria are QUICKLY adapting to antibiotics and are getting stronger.  This is speeding up the process of antibiotic resistance among bacteria that can not only make livestock sick, but can also make humans sick.  When YOU get sick with one of these bacterial infections that is resistant to antibiotics, well, you may be screwed, because even fluoroquinolones don’t touch some of these nasty, antibiotic resistant, bacteria.

According to the CDC:

“Each year in the United States, at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections. Many more people die from other conditions that were complicated by an antibiotic-resistant infection.”

For a while the CDC, FDA and others, led by the pharma and big-ag lobbies, tried to BS (lie to) us all by saying that antibiotic resistance in livestock had nothing to do with antibiotic resistance to humans.  The 2013 CDC Report on Antibiotic / Antibmicrobial Resistance settled that argument as it noted that:

“Antibiotics are widely used in food-producing animals, and according to data published by FDA, there are more kilograms of antibiotics sold in the United States for food-producing animals than for people… This use contributes to the emergence of antibiotic-resistant bacteria in food-producing animals. Resistant bacteria in food-producing animals are of particular concern because these animals serve as carriers. Resistant bacteria can contaminate the foods that come from those animals, and people who consume these foods can develop antibiotic-resistant infections. Antibiotics must be used judiciously in humans and animals because both uses contribute to not only the emergence, but also the persistence and spread of antibiotic-resistant bacteria.”

Here is a good article in Wired explaining the CDC report – “CDC Threat Report: Yes, Agricultural Antibiotics Play a Role in Drug Resistance.”

The reports are in.  The scientific consensus has been stated.  Over-use of antibiotics in agriculture is hurting humans.  So, perhaps we should stop over-using antibiotics in agriculture.  That seems like a good idea.  Too bad the big-ag and pharma pockets are deep and they control the hearts and minds of legislators.  More info on that can be found here – http://www.healthline.com/health/antibiotics/politics-pork-and-poultry-why-legislation-has-not-passed

As bacteria in livestock become resistant to penicillin and sulfa antibiotics, fluoroquinolones will be used more frequently.  Fluoroquinolones already are being used in livestock, just not as frequently as other, safer, antibiotics.  But as bacteria become resistant to safer antibiotics, fluoroquinolone use will surely increase.  For humans as well, as antibiotic resistance increases, fluoroquinolone use will increase.  Doctors will have to pull out the “big guns” because the smaller ones will no longer work.

Antibiotic resistant bacteria are not only harming livestock and people, they are harming the earth itself.  The animals that are given antibiotics excrete those antibiotics (everybody poops – and pees) and the antibiotics go onto the earth / the soil.  This messes up the microbiome of the soil (yes, soil has a microbiome) and more antibiotic resistant bacteria thrive in the soil.  That’s the topic of THIS POST.  Our earth is, literally, getting floxed.  It’s going to get worse too, as stronger and stronger antibiotics become preferred in agriculture, because the traditional ones are no longer doing the job.  The fluoroquinolones will hurt the animals that they are given to, destroy the microbiome of the soil, and leave us Floxies with nothing to eat.  Great.

I wish I didn’t think this was going to happen in my lifetime, but I fear that it will.

The antibiotic arms race will likely continue, with increasingly powerful antibiotics being developed to compensate for antibiotic resistance.  Those synthetic antibiotics will likely have the same, or worse, devastating “side-effects” as fluoroquinolones.  Destruction of the microbiome and destruction of mitochondria is consequential for human health, animal health, and the health of the earth itself – the soil.  Though the importance of the microbiome is starting to be recognized, it may be too late to stop destroying our microbiome with antibiotics.  (The alternative is to fight pathogenic bacteria with helpful bacteria.)  We are accustomed to turning to drugs, and to wantonly killing bacteria.  I don’t see us stopping any time soon.

The bacteria will die – because there isn’t any political will to stop being foolish with antibiotics.  The insects (pests) will die – because there isn’t any political will to protect them from pesticides.  The bees will die – because corporate profits are, apparently, more important than our food supply.  The frogs will die – because no one understands non-linear hormonal responses.

Perhaps, with a painful number of human deaths from this ridiculousness, we’ll, collectively, stop being so stupid.  Maybe.  Because 23,000 human deaths per year (from antibiotic resistant bacteria) haven’t made policy-makers do squat about the over-use of antibiotics in agriculture.  Recommendations for prudent antibiotic use are put into place, but no actual changes are made.  Recommendations.  Recommendations will do nothing to solve this problem – nothing.

P.S. – Sorry for not being hopeful.  Here’s something I hope – I hope that the canaries in the coal mine are listened to.  That’s what we are – canaries.  Is anyone listening?

 

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The Earth is Floxed

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The use of antibiotics in agriculture is incredibly stupid on multiple levels. One level of stupidity to consider – the health of the microbiome of the soil is negatively affected by antibiotic treated animals excreting onto it. Soil has a microbiome. It’s not just ground up rocks. The health of the microbiome of the soil is necessary for healthy plants, and the over-use of antibiotics in agriculture is encouraging antibiotic resistance and pathogenic bacteria within soil.

Please read (and share) this post on Hormones Matter about how our soil is being affected by agricultural antibiotics:

THE EARTH IS FLOXED

Thank you!!!

Thank you for reading Floxie Hope!  I hope that all who read Floxie Hope gain insight, support, understanding and, most of all, HOPE.  If you would like to support Floxie Hope, all contributions will be greatly appreciated!  Click HERE to contribute to Floxie Hope.  Thank you!

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