Monthly Archives: January 2016

In Memory of Dr. Jay S. Cohen, M.D.

jaybookcasesm

I am saddened to report that Dr. Jay S. Cohen, M.D. passed away on December 6, 2015.

Dr. Cohen tirelessly advocated for recognition of medication adverse reactions, and specifically focused much of his work on bringing to light the many dangers of fluoroquinolone antibiotics.

Dr. Cohen’s articles about fluoroquinolone toxicity included:

  • New Warnings for Cipro, Levaquin, and other Quinolone Antibiotics
  • Peripheral neuropathy associated with fluoroquinolones
  • Reactions to Cipro, Levaquin, and Other Fluoroquinolone Antibiotics
  • Fluoroquinolone Toxicity Syndrome: A Letter to the Senate Committee on Health, Education & Labor
  • New Warnings for Cipro, Levaquin, and other Quinolone Antibiotics
  • Severe Reactions to Levaquin, Cipro and Other Fluoroquinolone Antibiotics: Are Doctors in Denial?

Many more articles by Dr. Jay S. Cohen can be found on his web site, www.medicationsense.com.

In addition to many articles, Dr. Cohen also published several books including, “How We Can Halt The Cipro & Levaquin Catastrophe: The Worst Medication Disaster In U.S. History.”

Dr. Cohen also consulted with and helped hundreds of people who had been injured by fluoroquinolone antibiotics. He was a powerful advocate and a friend to the community and many people in it. He is missed.

From the Jay S. Cohen M.D. Foundation Web Site:

Jay S. Cohen, M.D., was a nationally respected expert on prescription medications and natural therapies. Dr. Cohen earned his medical degree at Temple University in 1971. After completing his internship, he practiced general medicine and conducted ground-breaking research at UCLA in acupuncture and pain. In 1974, he undertook a residency in psychiatry and psychopharmacology at UCSD, where he was an Adjunct Associate Professor of Psychiatry. He was Chairman of the Medical Advisory Committee of the Erythromelalgia Association, and a Fellow of the American College of Nutrition.

Dr. Cohen’s interest in pharmacology led to independent research on the causes of medication side-effects that result in more than 100,000 deaths and 2 million hospitalizations each year. He noted that a substantial number of people are medication-sensitive, and, starting in 1996, published his findings in eight books and in leading medical journals, as well as articles in publications such as Newsweek, Bottom Line Health, and Life Extension Magazine. His work was featured in The New York Times, The Washington Post, Consumer Reports, Wall Street Journal, Modern Maturity, Women?s Day, and many other national magazines and newspapers. His book, Over Dose: The Case Against The Drug Companies (Tarcher/Putnam, 2001), was favorably reviewed by Publishers Weekly, Library Journal, and the The Journal of the American Medical Association.

In the course of his professional career, Dr. Cohen was featured on more than 100 radio programs across America, including NPR. He presented his findings at conferences of patients, doctors, drug industry executives, and attorneys. During the post-9/11 anthrax scare, his journal article on severe reactions to the class of antibiotics that includes Cipro and Levaquin, triggered a national debate and prompted the U.S. Center of Disease Control to withdraw its recommendation for their use in anthrax-exposure cases.

In 2002, Dr. Cohen was the keynote speaker at the Annual Science Day of the US. Food and Drug Administration’s Clinical Pharmacology Division. He debated top FDA officials on drug safety at several conferences, including those hosted by the American Society for Clinical Pharmacology and Therapeutics, and the Drug Information Association.

Dr. Cohen made his home in Del Mar, CA for over 40 years. He was an avid lover of learning, dogs and the beauty of Del Mar. He is survived by his son Rory Cohen and daughter-in-law Alana Cohen, and a nephew, Hal Cohen.

I had the opportunity to speak with Dr. Jay S. Cohen just a few months before he passed. He was thoughtful, generous and passionate about helping those who have been hurt by fluoroquinolones. He was a wonderful advocate whose work is greatly appreciated by many.

Condolences to Dr. Cohen’s family, friends and loved ones have been expressed extensively in the fluoroquinolone affected community. I echo those condolences. The fluoroquinolone harmed community, and the world, lost a brave and beloved man when Dr. Cohen passed.

He is appreciated and missed.

 

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Organofluorine Accumulation

organofluorine

I highly recommend that everyone read these two articles:

  1. The New York Times Magazine, “The Lawyer Who Became DuPont’s Worst Nightmare
  2. The Huffington Post, “Welcome to Beautiful Parkersburg, West Virginia: Home to one of the most brazen, deadly corporate gambits in U.S. history

They’re both brilliant exposés about DuPont’s dumping of perfluorooctanoic acid (PFOA) into the groundwater and land of Parkersburg, West Virginia. They reveal corporate malfeasance, regulator ineptitude, health risks, and environmental degradation that everyone should be aware of.

I also wrote an article that was published in Collective Evolution on the topic of organofluorine compounds like PFOA and how they affect our health – “Fluorine-Based Toxins Accumulate In The Body & Cause Multiple Health Problems.” You should read (and share) it too. 🙂

The articles listed above aren’t directly about fluoroquinolones. However, I suspect that they are connected to fluoroquinolones, and fluoroquinolone toxicity.

Both the chemical noted in the articles, perfluorooctanoic acid (PFOA, aka C8), and fluoroquinolones, are organofluorine compounds–meaning that they are composed of a carbon-fluorine bond. That fact alone does not mean that fluoroquinolones have the same consequences as perfluorooctanoic acid, but it does mean that similarities should be examined.

Organofluorine Bioaccumulation

The most worrisome aspect of perfluorinated compounds (PFCs) – man-made types of organofluorine compounds, like PFOA, that are used in many non-stick consumer products including cookwear and carpeting – is that they, essentially, never biodegrade. They stay in our bodies, and the environment, indefinitely, because there are no mechanisms in our bodies (or in the environment) to break them down.

Per the article, “Human detoxification of perfluorinated compounds:”

“it appears that most PFCs may be re-absorbed and returned to the liver through the enterohepatic circulation where the cycle of biliary excretion and re-absorption recommences repeatedly. In addition, there is increasing evidence in the literature that persistence in the body may also result from impaired renal excretion of some PFCs due to renal tubular re-absorption mediated through organic anion transporters.”

Additionally, PFCs accumulate in the environment and work their way up the food chain. They get absorbed into plants, then absorbed by the animals that eat the plants, then absorbed by the animals that eat those animals, until they are highly concentrated in the animals at the top of the food chain (us).

Do fluoroquinolones, or fluoroquinolone metabolites (specifically organofluorine metabolites), also stay in the body indefinitely–getting recycled and re-absorbed through enterohepatic circulation? Do they bioaccumulate indefinitely like PFCs?

Tolerance Thresholds for Fluoroquinolones

If fluoroquinolones (or their metabolites) bioaccumulate, it would make sense of some aspects of fluoroquinolone toxicity.

First, there appears to be a tolerance threshold for fluoroquinolones. People can tolerate fluoroquinolones well until they reach their personal tolerance threshold, at which time they get “floxed.” Some people are devastated by a single prescription of fluoroquinolones, while other people can tolerate several prescriptions before they get obliterated by fluoroquinolone toxicity. Personally, I was fine after my first exposure to ciprofloxacin in 2010–it was only after my second exposure in 2011 that I had an adverse reaction. (Of course, it should be noted that some people never reach their tolerance threshold and never experience getting “floxed.”)

Likewise, there appears to be a tolerance threshold for PFC exposure. People don’t get cancer, or colitis, or have children with birth-defects, after a single time cooking with a Teflon pan. Exposure to PFCs at high doses is necessary for their ill effects to become apparent. However, because of bioaccumulation, repeated small exposures (say, a decade of cooking in non-stick pans while living in a house with PFC-coated carpets) can lead to levels of PFCs in one’s body that are high, and can lead to negative health outcomes. That’s what makes the bioaccumulation situation so frightening–we all have PFCs in our blood* and every time we’re exposed to more, the toxic burden on our body increases.

Could our tolerance threshold for fluoroquinolones not only be a tolerance threshold for FQs, but also our tolerance threshold for all sources of organofluorine compounds (fluorinated pharmaceuticals, non-stick consumer goods, pesticides, etc.)?

Could the people who get “floxed” be the people with already high levels of PFCs who get pushed over the toxic edge by fluoroquinolones? Or, are the people who have adverse reactions to fluoroquinolones those who are particularly bad at metabolizing and eliminating organofluorine compounds / really good at holding onto and recirculating those toxins? Certainly, there must be some factors that differentiate those who suffer from adverse reactions to fluoroquinolones from those who don’t. There are any number of potential environmental and genetic factors, and maybe bioaccumulation of organofluorine compounds is a factor that should be considered (levels of PFCs and bioaccumulation may be due to a combination of both environmental and genetic factors).

The notion of a tolerance threshold for fluoroquinolones is reinforced by the cross-reactivity between fluoroquinolones. Once a person has an adverse reaction to a fluoroquinolone, all fluoroquinolones (not only the one they reacted badly to) are contraindicated for that person. This cross-reactivity may, or may not, have to do with an accumulation of organofluorine compounds or their metabolites (please keep in mind that there are other mechanisms for the cross-reactivity phenomenon).

Though bioaccumulation of toxins (including, but not limited to organofluorine compounds like fluoroquinolones and PFCs) is a problem that needs examination, I don’t think that the situation is hopeless for those who carry a high burden of toxins. Lifestyle changes may be necessary to avoid toxins and pollutants, and our natural cleansing organs may need to be supported a bit (through diet, supplements, etc.), but there is plenty of evidence that healing from fluoroquinolone toxicity is possible, and despite all the pollution in Parkersburg, WV, there are still some healthy people there. Bioaccumulation of toxins is frightening, for sure, but though our bodies are not well equipped to deal with organofluorine compounds, we do have detoxification and healing mechanisms that are helpful.

Years of Poisoning and Pollution

DuPont first started using PFOA in 1951. Internal documents reveal that they knew that PFOA was toxic at that time, yet they still used it in consumer products and disposed of it improperly. It wasn’t until 2011 that independent scientists, “began to release their findings: there was a ‘probable link’ between PFOA and kidney cancer, testicular cancer, thyroid disease, high cholesterol, pre-eclampsia and ulcerative colitis.” It wasn’t until 2016 that major news organizations like The New York Times and The Huffington Post began to publish articles about PFOA. Additionally, if you read “The Lawyer Who Became DuPont’s Worst Nightmare” you will note just how many things fell into place for the news of the toxicity of PFOA to reach the public.

How long will it take for fluoroquinolone-injury lawsuits to prevail, for studies examining whether or not fluoroquinolone-use is connected to the many diseases of modernity, and for major investigative journalism pieces to be completed? How long will it take for fluoroquinolone toxicity to reach public consciousness and for systems to change? As far as I know, no one is even looking at whether or not toxic fluorine metabolites are formed by fluoroquinolones, or whether or not they bioaccumulate like PFCs. Though there are hundreds of articles about the harm that fluoroquinolones do to cells (especially to mitochondria – BTW organofluorine metabolites like fluoroacetate and fluorocitrate wreak havoc on mitochondria. Unfluorinated quinolones may too though, so keep that in mind.), the only researcher who I know of who is even making steps toward connecting fluoroquinolone-use to the chronic, multi-symptom diseases of modernity is Dr. Golomb with The Fluoroquinolone Effects Study. I hope that more researchers study the many aspects of fluoroquinolone toxicity (mitochondria damage, mineral depletion, neurotransmitter dis-regulation, microbiome damage, thyroid damage, endocrine disruption, organofluorine metabolite accumulation, etc.) and that the questions raised in this post, and throughout this site, are answered.

Maybe we truly are canaries in the coalmine–warning everyone about the dangers, not only of fluoroquinolones, but of all fluorinated drugs, and also for the accumulated organofluorine compounds in our environment. It’s certainly a hypothesis that should be looked at. I would hate for 65 years of organofluorine compound metabolite accumulation to occur because of fluorinated drug use before an examination even takes place. After all, the toxicity of other organofluorine compounds is well-documented, so I’m not sure why fluorinated drugs are assumed to be safe. Fluoroquinolones certainly aren’t safe, and they need to be researched much more thoroughly.

Conclusions

I have neither the resources nor the expertise to know whether or not adverse reactions to fluorinated drugs, like fluoroquinolones, are related to the buildup of PFCs in our bodies and our environment. There are some aspects of fluoroquinolone toxicity that make more sense when it is noted that bioaccumulation is possible. Given that fluoroquinolones have a fluorine-carbon bond, and that other organofluorine compounds have been shown to bioaccumulate and wreak havoc on health, I think it’s something that should be explored.

Regardless of whether or not fluoroquinolones contribute to organofluorine load, we should all be concerned about PFCs in our bodies and our environment. Bioaccumulation of PFCs is going to make the problem worse and worse as time goes on. As chemical producing corporations like DuPont blatantly lie as they shift from one organofluorine pollutant to another, claiming that the current one is safer than the proven-toxic past ones–even though it’s not, more and more PFCs will accumulate. The potential detrimental effects of accumulated PFCs to our personal and collective health are yet to be determined. I suspect that health outcomes for humans, and all the other animals on the planet that are exposed to these compounds, will get worse and worse as time goes on and as they bioaccumulate. Perhaps I’m a pessimist though, and the consequences of organofluorine compounds in our environment won’t be as dire as I fear. We, or our children or grandchildren, shall see. Surely, future people will look back at this time and think that we are all fools for letting unregulated, greedy, corporate giants like DuPont release permanent, harmful pollutants into the world simply so they could make millions on non-stick pans and stain-resistant carpets. What a sad, sad, state of the world.

 

* “C8 was being detected everywhere—produce and beef in American grocery stores, polar bears in the Arctic, children in the remote Faeroe Islands. One analysis of blood banks from around the world showed that nearly all of the blood contained C8. The lone exception was a set of archived samples that had been collected from Korean War veterans before 1952.” (Source)

 

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48 Tips for Overcoming Insomnia

Insomnia FQ toxicity

Insomnia is horrible and it can wreak havoc on all areas of your life. If you can’t sleep, you can’t think, and if you can’t think, you can’t do your job well. It puts your emotions on edge and relationships suffer. It can affect your appetite and sleep-deprived people will either eat too much or too little. Prolonged insomnia can have seriously detrimental effects on mental health, and after a while of not sleeping, people start to hallucinate.

Unfortunately, insomnia is something that many “floxies” suffer from. Fluoroquinolones inhibit the neurotransmitter GABA-A, “the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays the principal role in reducing neuronal excitability throughout the nervous system.” Fluoroquinolones have similar effects on neurotransmitters to what happens when people go through benzodiazepine withdrawal–antagonism of the GABA-A receptors which leads to anxiety, psychosis, paranoia, paraesthesia, tinnitus, hypersensitivity to light and sound, tremors, suicidal ideation and tendencies, and INSOMNIA.

There is a vicious cycle when it comes to insomnia–if you can’t sleep, your anxiety and paranoia increase, which can make you even less able to sleep, and the cycle goes on.

Fortunately, many people have found relief from their insomnia. Here are some tips that people have provided for things that have helped them to sleep, and have relieved the cycle of fluoroquinolone-induced insomnia:

  1. Eliminate all sources of caffeine from your diet.
  2. Sleep in a completely dark room–either black-out your windows or set up a cot in a closet.
  3. Use ear-plugs.
  4. Melatonin.
  5. Visualize sleeping soundly in a peaceful place.
  6. Eat a banana before bed.
  7. EHT from Nerium.
  8. Cannabis.
  9. Eliminate alcohol from your diet.
  10. Calm Spirit Pills (Chinese Medicine).
  11. Meditation.
  12. Epsom salt baths.
  13. Borax baths.
  14. Baking soda baths.
  15. Prayer.
  16. A few spritz of magnesium oil spray and a couple of drops of Frankincense oil on a piece of cloth under a pillowcase.
  17. Kavinace PM.
  18. Benadryl.
  19. Tylenol PM.
  20. Herbal/Supplement sleep aids
  21. Honey with sea salt under the tongue.
  22. Valerian root.
  23. Low-dose naltrexone.
  24. EFT (Emotional Freedom Technique).
  25. Acupuncture.
  26. Zinc monomethionine.
  27. Magnesium.
  28. Tart cherry juice.
  29. Exercise 4+ hours before bedtime.
  30. Cut down on salt intake.
  31. Hydrochloric Acid (HCL) supplement.
  32. No screens (computer, phone, t.v.) before bed.
  33. Gaia Sound Sleep.
  34. Natural Calm Magnesium.
  35. 5HTP.
  36. Emperor’s Tea Pills (Chinese Medicine).
  37. Hypnotization (through an app).
  38. Bioidentical progesterone.
  39. Ambien.
  40. Benzodiazepines.
  41. Turn off wi-fi.
  42. Avoid soy.
  43. Sleep-restriction therapy.
  44. Listen to the radio on a foreign station or a boring station.
  45. Relaxing music.
  46. Silva Meditation For Deep Relaxation.
  47. Breathing Exercises.
  48. Don’t eat red-meat for dinner.

I hope that these tips help you! Insomnia can be debilitating and tortuous. I hope that you find some relief from your insomnia through using some of the methods mentioned above!

Sources:

  1. Toxicology Mechanisms and Methods, “Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms.
  2. British Journal of Clinical Pharmacology, “Neurotoxic effects associated with antibiotic use: management considerations

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Is Fluoroquinolone Toxicity Quinolone Toxicity or Fluorine Toxicity?

Cipro Molecular Structure

As should be obvious from their name, FLUOROquinolones are fluorinated drugs.

A little history for you: Nalidixic Acid is the backbone of all fluoroquinolones. It was discovered by George Lesher in 1962, and it started to be used as an antibiotic in 1967. Nalidixic acid, and the first-generation quinolones that were derived from it, were not widely used because they lacked bioavailability and were associated with the rapid development of bacterial resistance (1). To increase bioavailability, a fluorine atom was added to the nalidixic acid backbone at position 6, bonded to carbon (2 and 3). This increased bioavailability of the quinolones greatly, and their use increased exponentially (more than 26 million prescriptions for fluoroquinolones were given out in 2011 alone).

In addition to increasing the bioavailability of fluoroquinolones, did the addition of the fluorine increase the toxicity of the fluoroquinolones?

How much of Fluoroquinolone Toxicity is due to the quinolone core and how much of it is due to the fluorine addition that, as it is intended, penetrates cells and increases the quinolone efficacy and potency? Is Fluoroquinolone Toxicity quinolone toxicity, or is it fluorine toxicity?

I’ve always been of the opinion that the quinolone core is toxic and that the fluorine just increases the bioavailability and toxicity of the quinolones, and that fluoroquinolone toxicity is quinolone toxicity, not fluorine toxicity. However, recently I’ve been reading about the effects of fluoride, and, more specifically, fluoro-organic metabolites like fluoracetate and fluorocitrate, and I have been considering the possibility that fluoroquinolone toxicity is a result of the addition of the fluorine atom to the quinolone core. I intend to explore the possibility that fluoroquinolones are metabolized into poisonous metabolites like fluoracetate and fluorocitrate in future posts. In this post, I’ll start the conversation by looking at some evidence that the quinolone core is the toxic part of fluoroquinolones, as well as some evidence that the fluorine is the main source of toxicity.

There is a lot of grey area in the question of whether fluoroquinolone toxicity is caused by the quinolone core, the fluorine attachment, or both. It is likely, in my opinion, that both are toxic. There are undoubtably complex feedback and feed-forward loops in our biochemistry that may make one increase the toxicity of the other too.

fluoroquinolone-lawsuit-banner-trulaw

Argument #1 – Quinolones were toxic before the fluorine was added.

Nalidixic acid and the first-generation quinolones that weren’t fluorinated, have serious and severe adverse effects. For example, Cinoxacin, a first-generation unfluorinated quinolone, has the following adverse-effects (4):

  • difficulty breathing
  • fever
  • increased sensitivity to the sun or ultraviolet light
  • irregular heartbeat, palpitations, or chest pain
  • joint, muscle, or tendon pain
  • nervousness, restlessness, anxiety
  • severe stomach or abdominal pain
  • severe or watery diarrhea
  • seizures (convulsions)
  • skin rash or itching
  • swelling of the face or neck
  • vomiting
  • diarrhea (loose stools)
  • difficulty sleeping
  • dizziness, drowsiness
  • headache
  • nausea
  • stomach upset

In a study of 1,118 patients who took Cinoxacin, it was found that many experienced the following (5):

Gastrointestinal: Nausea was reported most commonly and occurred in less than 3 in 100 patients. Other side effects, occurring less frequently (1 in 100), were anorexia, vomiting, abdominal cramps/pain, perverse taste, and diarrhea.

Central Nervous System: The most frequent side effects were headache and dizziness, reported by 1 in 100 patients. Other adverse reactions possibly related to Cinobac (cinoxacin) include insomnia, drowsiness, tingling sensation, perineal burning, photophobia, and tinnitus. These were reported by less than 1 in 100 patients.

Hypersensitivity: Rash, urticaria, pruritus, edema, angioedema, and eosinophilia were reported by less than 3 in 100 patients. Rare cases of anaphylactic reactions have been reported. Toxic epidermal necrolysis has been reported very rarely. Erythema multiforme and Stevens-Johnson syndrome have been reported with cinoxacin and other drugs in this class.

Hematologic: Rare reports of thrombocytopenia.

Though those aren’t comprehensive lists of fluoroquinolone toxicity symptoms, they’re pretty close. Even reviews of modern fluorinated fluoroquinolones rarely have more comprehensive lists of adverse-effects than the lists for Cinoxacin above.

Argument #2 – The fluorine increases the toxicity so much that it is largely responsible for fluoroquinolone toxicity.

From various publications:

“Fluorinated C-6 position was shown to contribute to an overall toxicity of the molecule and its CNS activity” (6).

“Fluoroquinolone antibiotics may cause tendon pain and rupture… The non-fluorinated quinolone nalidixic acid had lesser or no effects” (7).

“Although the etiology of fluoroquinolone-associated muscle disorders has yet to be fully elucidated, evidence supports a relationship with both latent myopathic disorders and the fluorine atom in fluoroquinolones… Further support for the hypothesis that fluorine may be the trigger for fluoroquinolone-associated myopathy comes from the fact that no adverse muscular events have been reported with unfluorinated quinolones” (8).

“The potential of this non-fluorinated series became clearer when two independent reports showed that non-fluorinated quinolones were consistently less genotoxic than their 6-fluorinated counterparts” (9).

Argument #3 – The fluorine is toxic, and fluoroquinolone toxicity is fluoride toxicity.

This post would be way too long if I went into detail about this argument, but I will note that the symptoms of fluoride toxicity are similar to the symptoms of fluoroquinolone toxicity. Fluoride toxicity is a multi-symptom, chronic illness that affects all systems in the body….. just like fluoroquinolone toxicity. There are people who have been exposed to other sources of fluoride who have very similar symptoms to those of people who have been “floxed.”

Conflicting Evidence

I suspect that the reason for the conflicting evidence presented above is that long-term studies of fluoroquinolones (and of other sources of fluorine/fluoride) have never been done–or, if they have been done, they have not been responded to appropriately, as there is no movement (that I’m aware of) to stop the fluorination of drugs, and the movements to stop the fluoridation of water constantly run up against obstacles including the accusation of being “conspiracy theorists.” In the short-term, and after limited exposure, many people (and lab rats) are fine. It is only after an accumulation of cellular damage occurs that a threshold is crossed, and multi-symptom, chronic illness results. In the post, The Fluoroquinolone Time Bomb – Answers in the Mitochondria, I go over the delayed reactions and tolerance thresholds that occur with fluoroquinolone adverse reactions. It should be noted that fluoride also accumulates in the body, there is a tolerance threshold for it, and fluorine metabolites damage mitochondria. In order to see the damage that is done by fluoroquinolones (and possibly other sources of fluoride like other fluorinated drugs, PFCs, and even fluoridated water) long-term studies need to be done. Studies that only examine a short exposure to fluoroquinolones, and that don’t look at adverse reactions that occur weeks, months, or even years after exposure to the drug has stopped, are not approaching these drugs appropriately. Short-term studies show that these drugs are less risky than they actually are in the long term, and/or after repeated exposure. Long-term studies are needed to show the real risks of fluoroquinolones.

Anecdotes

I recovered while drinking fluoridated water and using fluoridated toothpaste. I have never noticed any immediate ill effects from fluoride exposure.

However… some people have recovered from fluoroquinolone toxicity primarily through cutting all sources of fluoride from their lives. They have avoided fluorinated water for drinking, cooking/eating, and bathing, and have felt markedly better while avoiding fluoride. They notice that even small exposures to fluoride make them feel worse.

Nonconclusion

I honestly don’t know what to conclude. I think that both the quinolone core and the fluorine atom are dangerous. It’s undeniable that the fluorine makes the quinolone more powerful, and more dangerous. I am also starting to see that fluorine in itself can cause severe cellular damage. Fluorine is an undeniably reactive element that can bind to (and deplete) minerals, disrupt enzymatic reactions, and it may be wreaking havoc on those who exceed their tolerance for it.

BUT… the quinolone core is dangerous too. People can legitimately argue that there are many, many sources of fluorine in the world (20% of all prescription drugs are fluorinated, water and toothpaste are fluoridated, nonstick products like Teflon are fluorinated, air pollution has a lot of fluorine in it, etc.) and people who are exposed to those things don’t get “floxed.”

BUT… maybe we need to look beyond the people who are dealing with fluoroquinolone toxicity, and look at the bigger picture of multi-symptom, chronic, mysterious diseases. I’m honestly not sure if the many diseases of modernity that have increased along with both fluoroquinolone use and the increase in overall exposure to fluoride—like autoimmune diseases, neurodegenerative diseases, mysterious diseases like fibromyalgia and ME/CFS, mitochondrial diseases, autonomic nervous system diseases, autism, etc.–have anything to do with fluorine/fluoride exposure, or not. Studies, especially appropriately long-term studies, that examine the various sources of fluorine/fluoride, and their cumulative effects, haven’t been done. (Most people assume that things like this have been looked at thoroughly. Don’t assume that–they haven’t been.)

Action Plan

Whether we’re dealing with quinolone toxicity or fluorine toxicity, the result is mitochondrial damage and dysfunction, oxidative stress, mineral depletion, a disrupted microbiome, and more. Research on antioxidant supplementation has shown promising results for floxies, and for people dealing with the more recognized diseases of modernity. Mineral replacement is recommended whether cellular minerals are being displaced by the quinolone core or the fluorine. The healing tips noted in the stories on Floxie Hope, and the supplements and other protocols mentioned in The Fluoroquinolone Toxicity Solution, are helpful. Cutting fluoride exposure is also recommended by many “floxies,” and perhaps avoiding all sources of fluoride (fluoridated water, toothpaste, many supplements and pharmaceuticals contain fluorine, and nonstick products like teflon do as well) will be the key for healing for you. I know that avoiding fluoride and fluorine has helped others to heal.

Sources:

  1. The Canadian Journal of Infectious Diseases, “Safety of fluoroquinolones: An update
  2. Dartmouth, “Deconstructing Molecules: Cipro
  3. International Journal of Comprehensive Pharmacy, “SYNTHESIS OF NEW LEVOFLOXACIN DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY
  4. University of Utah Health Care, “Cinoxacin capsules
  5. RxList, “Cinobac Side Effects Center
  6. German, NA, Design and synthesis of novel molecules for overcoming bacterial resistance to fluoroquinolones. The University of Iowa 2007, p. 16.
  7. Rheumatology, “Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells
  8. Physical Medicine and Rehabilitation (PM & R) “Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population
  9. Current Medicinal Chemistry, “Discovery, Structure-Activity Relationships and Unique Properties of Non- Fluorinated Quinolones (NFQs)

 

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