Tag Archives: Connective tissue

Prominent Activist Notes Possible Connections Between Fluoroquinolones and ME/CFS

I’m a big fan of Jennifer Brea–an activist and advocate for those with ME (Myalgic Encephalomyelitis – also known as Chronic Fatigue Syndrome or CFS), and the filmmaker behind the wonderful documentary Unrest. She is also heavily involved with the ME Action Network, “A global, grassroots network for people with Myalgic Encephalomyelitis and Chronic Fatigue Syndrome,” and a blogger on Medium. She is powerful, thoughtful, interesting, insightful, an amazing leader, and she has helped thousands (maybe millions) of people with ME to live with, and maintain hope through, a horrible and debilitating disease. She has brought understanding of the horror of ME to people in a way that is empathetic and thought provoking. She is a wonderful advocate for her community.

AND, I’m excited to tell the “floxed” community…

Fluoroquinolones are on her radar as a possible cause of connective tissue disorders that may lead to ME.

In her July 10, 2019 post, “Onset: Part III (Connections),” she notes that antibiotics are a potential cause of collagen and connective tissue disorders:

Antibiotics: doxycycline, which anecdotally some patients have benefited from, inhibits MMPs. Fluroquinolone antiobiotics, which can produce an ME/CFS-like illness, increases MMPs and in December 2018, the FDA issued a warning against its use in patients with Ehlers-Danlos Syndrome and Marfan Syndrome.”

Indeed, fluoroquinolones increase production of MMPs–a category of enzymes that are capable of degrading all kinds of extracellular matrix proteins including, but not limited to, the structural proteins of the aortic wall.

The article, “Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin‐1β in human tendon‐derived cells” notes the following:

In this study, we have shown that the antibiotic ciprofloxacin, which induces tendon pain in some patients (1) and tendon pathology in rodents (3, 4), can increase MMP expression in human tendon‐derived fibroblasts. Specifically, ciprofloxacin potentiated IL‐1β–stimulated expression of MMP‐3 at both the mRNA and protein level.

Tendon pain and degeneration have been associated with an increase in the normal turnover of matrix proteins (9, 10, 12). MMP‐3 has a broad substrate specificity; it is able to degrade matrix components including type III collagen and the proteoglycans aggrecan and versican, and is capable of activating a variety of other MMPs and pro–tumor necrosis factor (11). However, its role in tendon physiology and pathology has not been clearly defined.

Our results raise the possibility that a combination of fluoroquinolone and (fluoroquinolone‐induced) inflammatory mediators might result in the inappropriate or unbalanced expression of MMPs.

Changes in expression of matrix components such as collagen and proteoglycans have also been reported in response to various fluoroquinolones.

The increase in MMP expression may not be the only way that fluoroquinolones damage and destroy connective tissues, but it’s almost certainly one way.

More information about the increase of MMP expression caused by fluoroquinolone antibiotics can be found in the post, “Fluoroquinolones Increase Expression of MMPs” as well as these links:

In a couple posts on this site, I have noted that ME/CFS caused by connective tissue disorders may be proceeded (even caused by) fluoroquinolone exposure. You can read about these theories in the posts Are Fluoroquinolones Causing Connective Tissue Disorders that are Leading to ME/CFS? and Do Fluoroquinolones Cause Cerebrospinal Fluid Leaks?

In Jen Brea’s post she note that there are many causes of collagen and connective tissue disorders, including viral infections, bacterial infections, mold, pregnancy, surgery, car accident, concussion, Ehlers-Danlos Syndrome and other connective tissue disorders, and sex hormones.

It is likely that many people who suffer from ME/CFS, as well as many “floxies,” have been exposed to several of these triggers. Personally, I was exposed to both fluoroquinolone antibiotics and changes in sex hormones (my period) when the flox bomb went off in me. I don’t think I had an actual infection, but most people also have a concurrent bacterial or viral infection when they take fluoroquinolones. I have also surmised in the past that perhaps floxies (as well as people with ME/CFS) have a yet-to-be-discovered form of Ehlers-Danlos syndrome. I also think that there are genetic predispositions to both fluoroquinolone toxicity and ME/CFS, and that the RCCX theory by Dr. Sharon Meglathery is a good place to start when looking at genetic predispositions for all sorts of mysterious illnesses. On the site https://www.rccxandillness.com/ Dr. Meglathery states:

“I believe that the RCCX Theory solves some of medicine and psychiatry’s greatest mysteries. The RCCX Theory explains the co-inheritance of a wide range of overlapping chronic medical conditions in individuals and families (EDS/hypermobility, autoimmune diseases, chronic fatiguing illness, psychiatric conditions, autism, etc.). It explains the underlying pathophysiology of chronic fatiguing illnesses with so many overlapping features (EDS-HT, CFS, Chronic Lyme Disease, Fibromyalgia, toxic mold, Epstein Barr Infection, MCAS, POTS, etc.). And finally, it reveals the gene which I believe confers a predisposition toward brilliance, gender fluidity, autistic features, and stress vulnerability, as well as the entire spectrum of psychiatric conditions (other than schizophrenia which can be co-inherited).”

Though there is significant overlap between fluoroquinolone toxicity and ME/CFS they are not the same, and there are many people suffering from ME/CFS who had other triggers set off their illness. With that said, the evidence that ME/CFS is a connective tissue disorder is mounting, and if a debilitating disease like ME/CFS is caused by disordered connective tissues, perhaps drugs that are known to cause connective tissue disorders (fluoroquinolones) shouldn’t be prescribed by the millions each year.

I appreciate that a leader like Jennifer Brea has the fluoroquinolone connection on her radar, and I hope that those in the ME/CFS community that are floxies as well are able to gain insight and support from both our communities.

I also suggest that everyone watch her wonderful film, Unrest. As a recent floxie hope commenter said, “It’s a good window of what it’s like to live with a chronic illness and I think a great example of what it’s like to have a supportive partner (her husband Omar).” Here’s the trailer:

At the risk of sounding too much like a fan-girl, I’m pretty stoked that fluoroquinolone toxicity is on Jen Brea’s radar, because I think she’s amazing. Read and watch her work, and I think you’ll agree. Much of it will likely resonate with many “floxies” as well.

*****

 

Are Fluoroquinolones Causing Connective Tissue Disorders that are Leading to ME/CFS?

The symptoms of fluoroquinolone toxicity often mimic those of ME/CFS (Myalgic encephalomyelitis/chronic fatigue syndrome). Many people suffering from fluoroquinolone toxicity experience debilitating fatigue, and some are bed-bound and permanently disabled from this symptom, along with all the others that come along with fluoroquinolone toxicity. Both fluoroquinolone toxicity and ME/CFS are multi-symptom, chronic syndromes that are poorly understood and often disregarded by those in the medical community. Research into the mechanisms behind both fluoroquinolone toxicity and ME/CFS show that mitochondria (the energy centers of our cells) are likely related to both diseases, and so is autonomic nervous system dysfunction, mast cell activation, metabolomics, epigenetics, immune system dysfunction, hormonal imbalances, and other areas of human biology. Both fluoroquinolone toxicity and ME/CFS also have significant overlap with other diseases such as Ehlers-Danlos syndromes (EDS), Postural orthostatic tachycardia syndrome (POTS), and fibromyalgia.

The similarities between fluoroquinolone toxicity and ME/CFS may mean that they have a similar root mechanism…. or they may not. The root cause of fluoroquinolone toxicity is, of course, fluoroquinolones. (The mechanism behind fluoroquinolone toxicity is much more complex and the answer to the question of HOW fluoroquinolones hurt people is still being uncovered.) Most people who have ME/CFS don’t report that their symptoms started with fluoroquinolone exposure (though there is almost certainly some overlap, and there are likely some people who have been diagnosed with ME/CFS whose disease started with a fluoroquinolone prescription). There seem to be a variety of triggers that set off ME/CFS in previously healthy individuals, including, but not limited to, mold exposure and sensitivity, and exposure to a viral infection that the body never fully recovers from.

While it is possible that there are many cases of ME/CFS that were brought on by fluoroquinolones, and thus are “actually” fluoroquinolone toxicity (labels, shmables), it is also possible that both diseases/syndromes have a similar underlying mechanism despite different causes, and it is also possible that though the symptoms and features of both diseases are similar, they are actually different on a mechanistic and/or cellular level.

Though the possibilities for differences between fluoroquinolone toxicity and ME/CFS are potentially significant, the similarities are obvious, and it is likely that research that helps ME/CFS sufferers will help fluoroquinolone toxicity sufferers.

There is a theory about the mechanism behind ME/CFS that has recently come to my attention that could, potentially, tie it more directly to fluoroquinolone toxicity. The theory, in a nutshell, is this:

Some people with ME/CFS have an underlying predisposition for EDS, and thus collagen synthesis is disordered and connective tissues are weakened. The ligaments of the craniocervical junction (where your skull meets your first vertebra) become weak and this leads to craniocervical instability (CCI) and atlantoaxial instability (AAI) (together, CCI/AAI). When people suffer from CCI/AAI their neck ligaments don’t sufficiently hold up their head and their brain stems are compressed into their spines. This causes many symptoms of ME/CFS. (I’m not sure exactly how – ask someone who has done far more research into ME/CFS and/or CCI/AAI than me.)

You can read about how CCI/AAI relates to ME/CFS in these two links:

  1. MEchanical Basis
  2. A new diagnosis to add to the list: I have craniocervical and atlantoaxial instability

How does this relate to fluoroquinlones?

It is well known that fluoroquinolone antibiotics (Cipro/ciprofloxacin, Levaquin/levofloxacin, Avelox/moxifloxacin, Floxin/ofloxacin, and a few others) damage connective tissues–including musculoskeletal connective tissues like tendons, cartilage, bone, and muscle, as well as other connective tissues such as ocular tissue (including the retina)eardrums, and cardiac/heart tissue. Multiple studies have found that fluoroquinolones are toxic and damaging to connective tissues. Given the wide differences in tissues that fluoroquinolones have been shown to deleteriously affect–from cartilage to cardiac tissue–it is reasonable to assert that they damage all connective tissues throughout the body. (Read any of the articles in the citations listed below for information about how fluoroquinolones damage connective tissues.)

Given that fluoroquinolones damage connective tissues (probably all connective tissues – see links below), it is possible that they weaken the tendons of the neck and thus lead to CCI/AAI. CCI/AAI then leads to multi-symptom chronic illness including all the symptoms of ME/CFS (which are too numerous to count).

This weakening of tendons and subsequent CCI/AAI likely occurs more often in people with underlying connective tissue disorders like EDS. I suspect (though I have no proof of this) that there are many kinds of EDS that have not yet been identified, and that more people have the genes for a variation of EDS than those who can currently be diagnosed with the disease. It’s also possible that a genetic predisposition toward EDS is not necessary for fluoroquinolones to cause extensive connective tissue damage, and that they do so in everyone who is exposed to them (at varying levels, of course). Fluoroquinolones have been shown to damage dog and rat connective tissues, especially tendons, and human connective tissues exposed to fluoroquinolones have also shown extensive damage both in-vitro and through analysis of people exposed to fluoroquinolones. I have a hard time believing that all the rats, puppies, and people whose tissues were sampled all had underlying EDS prior to their tissues being destroyed by fluoroquinolones. However, it’s possible that underlying genetic predispositions, including those for EDS, determine how severely people are affected by fluoroquinolones. More research is, of course, needed.

Are fluoroquinolones causing CCI/AAI? And is CCI/AAI leading to ME/CFS? Given the large number of studies showing that fluoroquinolones destroy connective tissues and interfere with collagen synthesis, it’s quite plausible (even likely) that they cause CCI/AAI. How, and if, CCI/AAI is connected with ME/CFS is another question. But given the experiences of the authors of MEchanical Basis and A new diagnosis to add to the list: I have craniocervical and atlantoaxial instability, it’s a possibility that is certainly worth exploring.

 

Sources for the assertion that fluoroquinolones cause connective tissue destruction and disordered collagen synthesis:

Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population. Hall, Mederic M. et al. PM&R , Volume 3 , Issue 2 , 132 – 142

Etminan M, Forooghian F, Brophy JM, Bird ST, Maberley D. Oral Fluoroquinolones and the Risk of Retinal Detachment. JAMA. 2012;307(13):1414-1419. doi:10.1001/jama.2012.383

Tsai WC, Hsu CC, Chen CP, et al. Ciprofloxacin up-regulates tendon cells to express matrix metalloproteinase-2 with degradation of type I collagen. J Orthop Res. 2011;29(1):67-73

Lee C, Lee MG, Chen Y, Lee S, Chen Y, Chen S, Chang S. Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone. JAMA Intern Med. 2015;175(11):1839-1847. doi:10.1001/jamainternmed.2015.5389

Kaleagasioglu F, Olcay E. Fluoroquinolone-induced tendinopathy: etiology and preventive measures. Tohoku J Exp Med. 2012;226(4):251-258.

Adel Alrwisan, Patrick J. Antonelli, Almut G. Winterstein; Quinolone Ear Drops After Tympanostomy Tubes and the Risk of Eardrum Perforation: A Retrospective Cohort Study. Clin Infect Dis 2017; 64 (8): 1052-1058. doi: 10.1093/cid/cix032

Dear Colleague Letters: Information about Fluoroquinolone Toxicity from Doctors to Doctors

Several doctors have written “Dear Doctor/Colleague” letters regarding the horrible, damaging effects of fluoroquinolones. I appreciate all of these doctors who are speaking out about the dangers of fluoroquinolones, and I encourage you to read, print, and share each of these letters:

Additionally, the following “Dear Colleague” letter from Lawrence W. Rodgers, Jr. MD was recently brought to my attention. Dr. Rodgers’ wife has suffered from the adverse-effects of fluoroquinolones, and he wrote this thoughtful letter to his colleagues about her experience and the experiences of some of his patients.

Dear Colleague:

I am writing this letter to describe my journey as a physician in understanding the potential devastating and life altering side effects of Fluoroquinolones on patients. I am a practicing ENT physician in Florida. My training included Medical School at the University of Florida where I was Alpha Omega Alpha and graduated 10th in my class. Residency training as an Ear, Nose, Throat and Head and Neck surgeon was completed at the University of Florida.

During my career as a physician in private practice I have prescribed oral Levaquin, Avelox and Cipro for over 20 years. Usually this was given for chronic sinusitis.

My wife was given oral Levaquin twice, Avelox once and then Factive over a four year period of time. Her first Levaquin precipitated peripheral neuropathy in August 2008. She had persistent and then worsening symptoms since that first injury seven years ago. In retrospect she suffered acute onset connective tissue symptomatology, severe neurocognitive injury, marked prolonged fatigue and peripheral neuropathy related to taking these antibiotics. The onset of these side effects varied from acute, within a few days of beginning the drug to later onset. To this day she suffers ongoing peripheral neuropathy, neurocognitive difficulty and persistent fatigue with joint and back pain, also visual change and thyroid dysfunction. Her life has been permanently altered. I consider myself a good physician but I was unable to recognize these injuries as arising from the Fluoroquinolones because I was not looking for these drugs as the culprit. The differential diagnosis was complicated. Now I realize these medications as the direct cause and effect.

As I realized the potential side effects of Fluoroquinolones I began looking for this in my patients. In my experience over the last two to three years three patients come to mind. One who experienced acute significant vertigo lasting almost three months from the use of oral Levaquin. A second patient with acute onset severe debilitating lower extremity pain from oral Levaquin caused him to be unable to work as a truck driver for two months. A third patient is a 23 year old girl given oral Levaquin by her primary care physician for sinusitis. She immediately experienced severe ankle and foot pain within a few days of taking oral Levaquin. This patient worked as a horse trainer and rode horses daily. She quickly became unable to do her job because of severe ankle pain as she tried to place her feet in the stirrups as she rode. The patient was referred to me because of persistent sinusitis. This was cleared with the use of other antibiotics. My young patient had persistent ongoing debilitating ankle and lower extremity pain and was unable to continue in the work she enjoyed. This was noted at her last visit with me to be persistent six months after discontinuing the Levaquin. More details concerning these patients are available if you would like to discuss them with me.

This is anecdotal but caused me to review other information and studies of the potential side effects of Fluoroquinolones. In my experience I conclude these are dangerous and potentially life altering medications and should only be used in life threatening situations. The most important adage I learned as a young medical student was “First do no harm”, a very valuable basic principle for any physician. It is my belief and experience that the over prescribing of these antibiotics violates this basic principle of medicine. I no longer prescribe Fluoroquinolones to my patients. I will be happy to discuss my experience at any time.

Sincerely,
Lawrence W. Rodgers, Jr. MD
Otolaryngology

I am grateful for all of the doctors who have taken the time to speak out to their colleagues about the dangers of fluoroquinolones! As more doctors realize the dangers of these drugs, more will follow in the footsteps of doctors like Dr. Rodgers who no longer prescribes fluoroquinolones to his patients.

 

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Ciprodex – Poison Marketed to Children

Ciprodex Ear Drops

Ciprodex is an ear drop that is used in children, especially children under the age of 3, the main people who get ear infections, that contains Cipro, a fluoroquinolone antibiotic, and Dexamethasone, a steroid. Let me list the ways in which this is HORRIFYING:

  1. Fluoroquinolones are dangerous drugs. Their adverse effects include DESTRUCTION of all connective tissue throughout the body. This includes tendons, ligaments, fascia and cartilage. Destroying the connective tissue of a growing child is a REALLY BAD IDEA. Fluoroquinolones also adversely effect the nervous systems – central, peripheral, and autonomic nervous systems. Destroying a child’s central nervous system, its BRAIN, is also a REALLY BAD IDEA. A child’s brain is not fully developed and to damage it with chemicals is unconscionable. Fluoroquinolones are so dangerous that many have been removed from the market due to serious adverse reactions and safety concerns. The fluoroquinolones that have been removed from the market include gatifloxacin, repafloxacin, temafloxacin,trovafloxacin and afloxacin. Cipro (ciprofloxacin) may be formulated in a way that makes it slightly less strong, or, if you’re feeling cynical, it may be formulated in a way that adverse effects tend to be delayed, and thus it is not perceived as being as dangerous as other, recalled, fluoroquinolones, but it’s still REALLY DANGEROUS. Hell, it messed me up pretty severely, and I was a strong and healthy 32 year old. I can only imagine what it would do to a child. I shudder at the thought.
  2. Fluoroquinolones should NEVER be co-administered with a steroid. They are contraindicated with steriods. Yet Bayer, in all its glory and brilliance, decided that it would be a good idea to combine a fluoroquinolone and a steroid in a single medication then market it to children. Awesome. Steroids weaken tendons, fluoroquinolones weaken tendons, putting them together is a toxic cocktail. Steroids also intensify the toxicity syndrome that is “Floxing.”
  3. Because Ciprodex is an ear drop, it doesn’t carry the same warnings as orally administered Cipro. I’m sure that a drug that goes into the digestive tract is metabolized differently than a drug that goes into the body via the ear. However, I am also sure that people can be floxed by ear and eye drops because I’ve talked to people who have been poisoned that way. To take the warning labels off of ear and eye drops is absurd. The drugs are still going into the body. Eyes and ears aren’t disconnected from the rest of the body just because they’re not directly connected to the digestive tract. I’m not asking anyone to believe in homeopathy or to go to a holistic physician, but I am saying that it is crazy to think that drugs that go into the ear and/or the eye don’t go into the body. Ears and eyes actually are part of the body, not separate floating entities completely disconnected from the rest of the being. Yet the FDA treats them this way and doesn’t demand the same warning labels on ear and eye drops. So parents are completely uninformed of the dangers of Ciprodex when they administer it to their children.
  4. Again Ciprodex is specifically marketed to children – what is wrong with these people? And what is wrong with the FDA? Children, the most inherently vulnerable people in our society, the people who are depending completely on others to take care of them, are being endangered at the least and permanently damaged at the worst, by pharmaceutical companies and a medical system that isn’t looking out for them. This is disgusting.

Here is the package insert for Ciprodex – http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0ed518de-4ae1-43d1-84ff-26872d9e6a0f . Some things to note in the insert are:

  1. The amount of Cipro in it is low. This is good. Seriously, thank God.
  2. It is approved for use in patients 6 months of age and older. This is appalling.
  3. CIPRODEX® Otic is contraindicated in patients with a history of hypersensitivity to ciprofloxacin, to other quinolones, or to any of the components in this medication.” So, if your baby starts having seizures, you may want to discontinue use of this drug because it turns out that your child now has a history of hypersensitivity to Cipro. Too bad they don’t mention that an adverse reaction isn’t reversible. And how, other than poisoning their children, are parents supposed to know whether or not their child has a history of hypersensitivity to these drugs?
  4. Serious acute hypersensitivity reactions may require immediate emergency treatment.” This implies that there is a treatment. There isn’t. If your child has an adverse reaction to this drug and you take him or her to the emergency room, he or she will likely be pumped full of steroids which will make him or her worse. Then the child will have connective tissue and nervous system issues for a while, possibly for the rest of his or her life. But sure, tell your doctor immediately if your child experiences a hypersensitive reaction. They won’t be able to do anything about it, but they may realize that they poisoned your child and may avoid doing it again in the future.
  5. If the infection is not improved after one week of treatment, cultures should be obtained to guide further treatment.” Cultures should be obtained before the administration of any antibiotic, period. Fluoroquinolones should not be used as a first line of defense against verified bacteria, period.
  6. The systemic administration of quinolones, including ciprofloxacin at doses much higher than given or absorbed by the otic route, has led to lesions or erosions of the cartilage in weight-bearing joints and other signs of arthropathy in immature animals of various species.” Yup. And I wouldn’t trust that the amount absorbed by the otic route is too small, especially seeing as everyone’s tolerance for fluoroquinolones seems to be different. Some people die after 2 pills, others take 90 before they have a reaction. Besides, the people who are testing these drugs are the ones selling them. Don’t trust the bastards.
  7. Guinea pigs dosed in the middle ear with CIPRODEX® Otic for one month exhibited no drug-related structural or functional changes of the cochlear hair cells and no lesions in the ossicles.” Well, it’s nice to know that their ears looked okay. Could they run though? Could they still find their way through a puzzle (or do whatever cognitive things guinea pigs can do?) How did their brains look? How did their tendons look? You don’t know because you weren’t looking? Oh…. I see.
  8. It is very important to use the ear drops for as long as the doctor has instructed, even if the symptoms improve.” It is very important to stop using fluoroquinolones as soon as possible after you start having an adverse reaction. Even after stopping administration of them, the adverse reaction can continue. Since we’re talking about children, it’s really important that you stop giving your children drugs that are poisoning them. Discontinue use immediately.
  9. Specific drug interaction studies have not been conducted with CIPRODEX® Otic.” I’ll tell you that NSAIDs and steroids trigger adverse reactions.
  10. Ciprofloxacin and corticosteroids, as a class, appear in (breast) milk following oral administration.” This is bad.
  11. No clinically relevant changes in hearing function were observed in 69 pediatric patients (age 4 to 12 years) treated with CIPRODEX® Otic and tested for audiometric parameters.” Your child will still be able to hear. That’s good. He or she may even be able to hear constant ringing (tinnitus), a common effect of fluoroquinolone toxicity. That’s bad.
  12. All of the adverse events listed are things involving the ear. Of course, adverse effects on the ear should be noted when studying ear drops, but the rest of the subject should also be noted. Of the 937 babies poisoned by Ciprodex, how many suffered from subsequent tendon pain? How many had cartilage, tendons, ligaments or fascia that were mal-formed? How many of these children subsequently read at a normal level? How many of these children displayed symptoms of autism? Could they run? Could the jump? Could they think? Could they concentrate? Did they have GI problems? ALL of these things are problems associated with fluoroquinolone toxicity, and if none of these questions were asked, then the researchers were LOOKING AT THE WRONG THINGS. THEY WERE ASKING THE WRONG QUESTIONS AND THE SAFETY AND EFFICACY OF THIS DRUG HAS NOT BEEN ESTABLISHED PROPERLY.

Even if all of the 937 children who were part of this study (side-note – don’t put your children in drug studies, just don’t) were fine, (and I doubt that is the case), effects of fluoroquinolones appear to be cumulative. So, even if these children didn’t react to these drugs the first time they were administered, they may react horribly to them when they get a fluoroquinolone in the future. A ticking time-bomb in their little body has been triggered, and it may get set off by future fluoroquinolone use, steroid use, NSAID use, or maybe even vaccines. (I’m not trying to vilify vaccines any more than I’m trying to vilify ibuprofen, the culprit is the fluoroquinolone, not the triggering toxin.)

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Ciprodex and plain Cipro ear drops are given to children constantly. A very good friend of mine brought her then 9-month old daughter to an emergency services clinic with a suspected ear infection. The doctor never cultured the bacteria in her ear, he simply prescribed her some Cipro ear drops. Thankfully I was with my friend when she went to pick up the drops and she never filled the prescription (because I flipped out). The infection went away on its own.

The following was recently posted in a Facebook group that I belong to – “My 20 month old grandson is visiting from GA. He had a follow-up appointment at Vanderbilt for his ear tubes. The physician prescribed Ciprodex Otic Suspension for an ear infection. This is a combination of Cipro and corticosterod given via the ear. The insert does not disclose all the potential side effects. The insert states there are other potential risk and if you have concerns get additional information from your health care provider (which we know how that goes). After watching my wife go from a normal life to a life with disabilities…..I am concerned. In my personal research, children are at high risk of floxing. Does anyone know of floxing via the ear drop forms of quinolone antibiotics?”

Children are being given this poison every day. A child has probably been given a dose of Ciprodex in the amount of time that it took you to read this post. I hope and pray that they are okay.  

 

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Taking Supplements After Fluoroquinolone Toxicity

Supplements After Fluoroquinolone Poisoning

“I am not a doctor and none of the advice contained in this site should be seen as a replacement for the advice of a doctor or other medical professional. Please be careful with all supplements and treatments that you self-administer. Trusted supervision by a medical professional is a good idea.”

That’s the disclaimer that I have up on the Stories page of Floxie Hope. I have no idea how solid it is as a disclaimer. I’m not a lawyer either. Please don’t hurt yourself or sue me.

The disclaimer is understood. Sure.  Fine. We all know that each individual’s experience is different, their biochemistry is different, no one on here is doing a controlled scientific experiment because it’s IMPOSSIBLE to do a controlled scientific experiment on yourself, and we even know that we should probably avoid getting medical advice on the internet.

Fine.

But can you blame us?  What are we supposed to do? The doctors, the people who prescribed us a poison that MESSED US UP, could chat with us, but most Floxies are understandably wary of listening to their doctors. Doctors also have no answers. They have no advice, no course of action for us to take, and no cure. I don’t blame them for not having answers.  They just don’t know. They have no idea what is going wrong in our bodies or how to fix it. It would be nice if they tried to understand, explored different theories, answered the questions in my “What is going on???” post (https://floxiehope.com/2013/06/20/test-post/) compiled a database of what helps and what hurts, looked for a cure, etc. But seeing as we’re fighting to even get our ailments acknowledged and linked to fluoroquinolones, it’s pretty far-fetched to think that meaningful research into a cure is going to be done any time soon.

So we seek answers on the internet. We try different supplements that have helped other people. Luckily, unlike pharmaceuticals, supplements have an excellent safety record. But the combinations that any of us try may hurt us. We may inadvertently harm ourselves while trying to heal ourselves.  We don’t intend for that to happen, but it may.

I’ve had two minor mishaps with supplements. I took a niacin supplement and got a “flush” that scared the $*&% out of me. I recently started taking Magnesium Malate / Malic Acid (same thing, two names). It’s given me a nice energy boost, but it’s made it difficult to sleep.  Having a little more energy is not even close to worth insomnia – for me. Neither of these mishaps caused me any real harm. They were learning experiences. Taking Cipro was also a learning experience, but a lot of harm was done and the lessons learned came at a ridiculously high price.

I think that most of the supplements that I take help me in one way or another. I wouldn’t take them if I didn’t think that they were beneficial. Yeah, I see the benefit in each of them, but my attachment to them and the money that I spend on them isn’t completely healthy. I spend way too much money on supplements and I am only sure of the benefits of some of them. Iron, magnesium and chlorophyll help me immensely. I eat beets and brewer’s yeast daily and I think that something in them (probably the uridine) is helpful. What helped me may not help you so only take that for what it’s worth, not a lot, only a teensy bit more than your doctor’s advice, seeing as he/she knows nothing about this. (I say that tongue-in-cheek – but don’t take my advice as medical advice, seriously, don’t.)

It would be really, really, really nice if our doctors could acknowledge what happened to us, note that they don’t know how to fix us, and explore alternative treatments with us.  Hahahahahaha, I know, pipe dream, hahahahahahaha – I crack myself up.

I’m sure that it’s frustrating for doctors to hear from patients, “I heard about this remedy on the internet,” but if they can’t give any answers, seriously, what are we supposed to do?

I see the people who look for answers to their ailments on the internet as hopeful. We HOPE that there is something out there that can help us, that can cure us. We hope that someone else has found the magic combination of supplements and diet that will lift our brain-fog and cure our connective tissues. I don’t care if this hope is entirely false, hope is a good thing. I hope that the stories of hope and healing in this web site are helpful to you and that what worked for others works for you as well. Please don’t hurt yourself with supplements or diet, and especially don’t get hurt with pharmaceuticals again. And as always, have hope.

 

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