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Kevin
8 years ago
…or to ask the question another way – in the absence of any other major symptoms (so a v minor floxing) does anyone have a view of when the caffeine intolerance gets better/disappears as this is a good measure of recovery of the CYP1A2 enzyme.
Many thanks for any contributions,
K
Debs
8 years ago
Page 110-114 of the flox report explains the Liver P450 enzyme pathway inhibition due to FQs in more detail . Mine have not yet recovered. I still cannot tolerate coffee & have been unable to tolerate any drug I have been prescribed since my most damaging floxing many years ago. The timeline in regards to recovery of these enzymes imo does seem to be dependent somewhat on severity of reaction.
Bruce Brannan
8 years ago
What has happened to Jason??? Has he assumed a new identity such as Paul, Angie A. or someone else or did he just take that dude up on the offer and move to the Bahamas???
Paul
8 years ago
I just trying to figure out this Oxalate dilemma. Isn’t having too much oxalates the same as having too much Uric Acid which is the cause of gout? Last year I had my Uric acid tested and it came in at 6.6 MG/DL which falls in the normal range was (2.6-8.7) for someone not floxed. I’m no expert on this but wouldn’t this be the way to see if you need to restrict oxalates from your diet? I was also reading that someone has been working on a probiotic to replace the certain bacteria that was eliminated during our floxing? Has this not been approved by now?
joanneg
8 years ago
Hi Everyone,
Just letting you all know my parathyroid surgery is scheduled for April 14th. I will post how it went, and if it helped with any of my floxing symptoms.
Paul
8 years ago
what probiotic works well to get our flora back to health without breaking the bank? there are so many.
Cindy Jones
8 years ago
So would going on a low oxalate diet without Vit D b safe I wonder?
Cipropoisoned
8 years ago
So, has anyone really recovered completely from this poisoning? I am 4 years and 2 months—- I am better, but not normal. Can I expect to ever go back to normal/baseline health? I personally doubt this is oxadative stress/Mitochondrial damage, etc. I think this is an autoimmune disease and we need to find a test that will look for those antibodies. Perhaps, the solution will be in immunosuppression like other autoimmune illnesses, or even Plasmaphoresis.
Having also been damaged myself from years of psychotropic drugs & also noting similar reaction in withdrawal from the same & the connection there with homeostasis ( psychotropic drugs cause chemical imbalances in the brain which are not there before you take them & withdrawal symptoms many experience from these are the brain desperately trying to regain homeostasis ( rebalance itself ) I personally am suspicious that as what happens when the brain is changed by psychotropic drugs that cycling in floxing has somewhat of a connection to the body again trying to rebalance itself in some way, is this something that just occurs ? do we take or use something which unbalances this new tightrope we walk ?. in regards to delayed symptoms FQs are chemo drugs, chemotherapy itself is known to cause delayed ADRs, further problems sometimes many years later down the line, otherwise known in oncology as ‘ late effects ‘. I note as with many, that my body is aging quicker than It should. mitochondrial damage / oxidative stress ? . The metabolites, what happens there ?. cellular senescence ? etc etc. questions upon questions. Whether I will still be around when this rubiks cube is eventually solved, how long is a piece of string as they say. at the end of the day even after so many years in this world i never stop learning, we are all to various degrees shooting in the dark here & hoping desperately to hit something. I believe floxing involves so many factors & so many variables, & imo even though we now know far more than we did, I feel we are only just beginning to scratch the surface .
Debs
8 years ago
This is one of the most common issues we unfortunately generally have to deal with the horrendous bodily weakness, I have this ongoing. exarcebated by various degrees of exertion, it earned me a misdiagnosis of ME/CFS. being floxed multiple times over many years has not helped. this bodily weakness has varied throughout the years in severity. This issue for me only went away for the time when I felt recovered from my first floxing. I eventually learned to adapt my life around this issue, fighting it just made me worse, & I being a dancer before my first floxing & not understanding why I could not get back to how I was before i got unwell found this very hard to do. I kept seeking answers & in fact my worse relapse was caused by me being put on a graded exercise programme for my misdiagnosed ME/CFS . However to stop fighting this , & adapting my life to encompass my new normal was one of the most helpful things I managed to do . I stopped beating myself up over it & I now live life at a different pace, live my life in the slow lane.
One positive thing floxing has taught me in regards to having to adapt my life in this way, something for which I will always be very grateful for, is that it taught me to appreciate the little things in life, which are in fact actually the biggest things. My family friends, my pets, nature, etc the tiny intricate details, a spiders web a cloud a beautiful sunset , so many people just rush headlong through life, they may look but do not actually see, So many people just do not realise this truth until it is much too late … that’s if they ever do.
Cipropoisoned
8 years ago
Hi joanneg,
I am glad my up dates provided you some comfort. Again, I have noticed progressive improvement, which hasn’t been linear, but nevertheless it has been improvement. My life is essentially normal, except that I can’t play soccer like I could. Unfortunately, late Jan. of this year, I noticed night sweats and from thereafter I had recurrence of the initial symptoms of 4 years ago: aches and pains in my joints, recurrent pin point skin pains that lasted a second or so that was diffuse and involved just about every part of my body, changes in my sleep pattern, had some anxiety recur after 3 years, dry mouth that was more noticeable than my early days of being floxed, my nose and eyes became cotton dry, the headaches recurred, fear crept into my life again, I lost interest in my normal activities for about 2 weeks, and I noticed a rash around my eyes (spider hemangioma) which I never had before, and my eyelids became dark (my kids call them raccoon eyes).
I know I am just going through another cycle—one that is more intense than the previous ones, but overall, I am very grateful for where I am. Anyhow, I still haven’t read a complete recovery story, which upsets me. I want to play soccer again :-(.
Last but not least, I wish you a safe surgery.
Cindy Jones
8 years ago
Hi cipropoisoned
Please do not be alarmed but I was concerned when you mentioned the night sweats. I had some serious night sweats for several months. I was eventually and I mean eventually diagnosed with a thyroid disorder caused by the antibiotics aka poison attacking the thyroid gland.
I was wondering if your thyroid funxtion has been screened or if you have had an ultra sound scan of your thyroid to rule out any thyroid disoders.
I also had antibody tests done . The ana was positive as was the test for glandular fever which is the ebv.
I am sorry to hear you are still having signs and symptoms.
I would like to see the perpetrators of these drugs behind bars.
Sorry about the rant.
SusanG
8 years ago
Hi I’m new. I took cipro 500 mg twice a day for 5 days 3 weeks ago for a misdiagnosed kidney infection from urgent care. Since then I’ve been feeling uncontrollably cold, lightheaded at times, and weak. My doctor took a bunch of blood tests and they all came back fine. When will I feel better? What do i do now? Was I poisoned is it gonna get worse? I’m so scared. I have a 3 year old daughter and I used to work out every day but I can’t now. I’m just lost about what to do to get better. Please help.
Angie A.
8 years ago
Has anyone heard any explanation (putting oxalate issue aside) why/how Cipro destroys magnesium levels in the body for days, weeks, months after stopping the medication?
Angie A.
8 years ago
Lisa, Did you get the DNA testing done for FQ damage? If so, wondering how that went?
Also wondering if there’s any labs doing this currently, or if it was just that one study? The more I read the deeper it gets and the deeper my fear for the long term : (
Ryan
8 years ago
I have never posted on any bog related to these drugs. What I know for certain: these drugs have seriously wounded my once pain free body.
I took Avelox TEN different times over 4 years, to treat recurring sinus infections (ignorant of the real cause: yeast overgrowth in the gut ruining my immune sytem’s ability to crush these constant infections. Since solved with high end probiotics…:)
I have had 4 different knee surgeries and a total knee replacement. Each knee injury took place during or shortly after a round of Avelox. Of course at the time I did not put the relationship
together.
Joint pain and tinnitus are a daily battle.
The majority of doctors I meet are completely unaware of the danger. My neighbor is an infectious disease specialist. She wrote my last script in fact. Completely clueless until I told her about the havoc the meds she slings around cause ou there.
Educate everyone you know. Tell them about the 2000 lawsuits J&J settled in 2012. Tell doctors. Tell anyone treating a sinus infection. Tell Physical therapists. I don’t make it a pity party: I don’t want anyone suffering the same or worse than I. They know when you sincerely care, and appreciate it immensely.
It’s my chiropractor who knows more about these nightmare drugs than any doctor I have ever met!
Good luck in your fight.
Mike
8 years ago
Ryan, do you mind me asking how old you are? You said you had 4 knee surgeries and a total knee. What kind of knee surgeries? Meniscus tears? Did your knees heal after surgery? I’m curious, I have popping, grinding, sand/ gravel feeling in my joints. The pain has spread over the years from my forearms to my shoulders to my knees to my hips to my wrists, ankles, hands, thumb and toes. I have torn ligaments that I am wondering if they will heal if I do surgery. My joints are falling apart. I can’t see how they would heal after surgery but I am going crazy being sedentary. My knees are by far the worst.
Can you elaborate on the 2000 lawsuits J & J settled in 2012?
…or to ask the question another way – in the absence of any other major symptoms (so a v minor floxing) does anyone have a view of when the caffeine intolerance gets better/disappears as this is a good measure of recovery of the CYP1A2 enzyme.
Many thanks for any contributions,
K
Page 110-114 of the flox report explains the Liver P450 enzyme pathway inhibition due to FQs in more detail . Mine have not yet recovered. I still cannot tolerate coffee & have been unable to tolerate any drug I have been prescribed since my most damaging floxing many years ago. The timeline in regards to recovery of these enzymes imo does seem to be dependent somewhat on severity of reaction.
What has happened to Jason??? Has he assumed a new identity such as Paul, Angie A. or someone else or did he just take that dude up on the offer and move to the Bahamas???
I just trying to figure out this Oxalate dilemma. Isn’t having too much oxalates the same as having too much Uric Acid which is the cause of gout? Last year I had my Uric acid tested and it came in at 6.6 MG/DL which falls in the normal range was (2.6-8.7) for someone not floxed. I’m no expert on this but wouldn’t this be the way to see if you need to restrict oxalates from your diet? I was also reading that someone has been working on a probiotic to replace the certain bacteria that was eliminated during our floxing? Has this not been approved by now?
Hi Everyone,
Just letting you all know my parathyroid surgery is scheduled for April 14th. I will post how it went, and if it helped with any of my floxing symptoms.
what probiotic works well to get our flora back to health without breaking the bank? there are so many.
So would going on a low oxalate diet without Vit D b safe I wonder?
So, has anyone really recovered completely from this poisoning? I am 4 years and 2 months—- I am better, but not normal. Can I expect to ever go back to normal/baseline health? I personally doubt this is oxadative stress/Mitochondrial damage, etc. I think this is an autoimmune disease and we need to find a test that will look for those antibodies. Perhaps, the solution will be in immunosuppression like other autoimmune illnesses, or even Plasmaphoresis.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249743/
http://m.molpharm.aspetjournals.org/content/50/5/1178.abstract
FYI Bruce that quote re prophylactic antibiotic is from American Family Physician http://www.aafp.org/afp/1998/0601/p2731.html
Having also been damaged myself from years of psychotropic drugs & also noting similar reaction in withdrawal from the same & the connection there with homeostasis ( psychotropic drugs cause chemical imbalances in the brain which are not there before you take them & withdrawal symptoms many experience from these are the brain desperately trying to regain homeostasis ( rebalance itself ) I personally am suspicious that as what happens when the brain is changed by psychotropic drugs that cycling in floxing has somewhat of a connection to the body again trying to rebalance itself in some way, is this something that just occurs ? do we take or use something which unbalances this new tightrope we walk ?. in regards to delayed symptoms FQs are chemo drugs, chemotherapy itself is known to cause delayed ADRs, further problems sometimes many years later down the line, otherwise known in oncology as ‘ late effects ‘. I note as with many, that my body is aging quicker than It should. mitochondrial damage / oxidative stress ? . The metabolites, what happens there ?. cellular senescence ? etc etc. questions upon questions. Whether I will still be around when this rubiks cube is eventually solved, how long is a piece of string as they say. at the end of the day even after so many years in this world i never stop learning, we are all to various degrees shooting in the dark here & hoping desperately to hit something. I believe floxing involves so many factors & so many variables, & imo even though we now know far more than we did, I feel we are only just beginning to scratch the surface .
This is one of the most common issues we unfortunately generally have to deal with the horrendous bodily weakness, I have this ongoing. exarcebated by various degrees of exertion, it earned me a misdiagnosis of ME/CFS. being floxed multiple times over many years has not helped. this bodily weakness has varied throughout the years in severity. This issue for me only went away for the time when I felt recovered from my first floxing. I eventually learned to adapt my life around this issue, fighting it just made me worse, & I being a dancer before my first floxing & not understanding why I could not get back to how I was before i got unwell found this very hard to do. I kept seeking answers & in fact my worse relapse was caused by me being put on a graded exercise programme for my misdiagnosed ME/CFS . However to stop fighting this , & adapting my life to encompass my new normal was one of the most helpful things I managed to do . I stopped beating myself up over it & I now live life at a different pace, live my life in the slow lane.
One positive thing floxing has taught me in regards to having to adapt my life in this way, something for which I will always be very grateful for, is that it taught me to appreciate the little things in life, which are in fact actually the biggest things. My family friends, my pets, nature, etc the tiny intricate details, a spiders web a cloud a beautiful sunset , so many people just rush headlong through life, they may look but do not actually see, So many people just do not realise this truth until it is much too late … that’s if they ever do.
Hi joanneg,
I am glad my up dates provided you some comfort. Again, I have noticed progressive improvement, which hasn’t been linear, but nevertheless it has been improvement. My life is essentially normal, except that I can’t play soccer like I could. Unfortunately, late Jan. of this year, I noticed night sweats and from thereafter I had recurrence of the initial symptoms of 4 years ago: aches and pains in my joints, recurrent pin point skin pains that lasted a second or so that was diffuse and involved just about every part of my body, changes in my sleep pattern, had some anxiety recur after 3 years, dry mouth that was more noticeable than my early days of being floxed, my nose and eyes became cotton dry, the headaches recurred, fear crept into my life again, I lost interest in my normal activities for about 2 weeks, and I noticed a rash around my eyes (spider hemangioma) which I never had before, and my eyelids became dark (my kids call them raccoon eyes).
I know I am just going through another cycle—one that is more intense than the previous ones, but overall, I am very grateful for where I am. Anyhow, I still haven’t read a complete recovery story, which upsets me. I want to play soccer again :-(.
Last but not least, I wish you a safe surgery.
Hi cipropoisoned
Please do not be alarmed but I was concerned when you mentioned the night sweats. I had some serious night sweats for several months. I was eventually and I mean eventually diagnosed with a thyroid disorder caused by the antibiotics aka poison attacking the thyroid gland.
I was wondering if your thyroid funxtion has been screened or if you have had an ultra sound scan of your thyroid to rule out any thyroid disoders.
I also had antibody tests done . The ana was positive as was the test for glandular fever which is the ebv.
I am sorry to hear you are still having signs and symptoms.
I would like to see the perpetrators of these drugs behind bars.
Sorry about the rant.
Hi I’m new. I took cipro 500 mg twice a day for 5 days 3 weeks ago for a misdiagnosed kidney infection from urgent care. Since then I’ve been feeling uncontrollably cold, lightheaded at times, and weak. My doctor took a bunch of blood tests and they all came back fine. When will I feel better? What do i do now? Was I poisoned is it gonna get worse? I’m so scared. I have a 3 year old daughter and I used to work out every day but I can’t now. I’m just lost about what to do to get better. Please help.
Has anyone heard any explanation (putting oxalate issue aside) why/how Cipro destroys magnesium levels in the body for days, weeks, months after stopping the medication?
Lisa, Did you get the DNA testing done for FQ damage? If so, wondering how that went?
Also wondering if there’s any labs doing this currently, or if it was just that one study? The more I read the deeper it gets and the deeper my fear for the long term : (
I have never posted on any bog related to these drugs. What I know for certain: these drugs have seriously wounded my once pain free body.
I took Avelox TEN different times over 4 years, to treat recurring sinus infections (ignorant of the real cause: yeast overgrowth in the gut ruining my immune sytem’s ability to crush these constant infections. Since solved with high end probiotics…:)
I have had 4 different knee surgeries and a total knee replacement. Each knee injury took place during or shortly after a round of Avelox. Of course at the time I did not put the relationship
together.
Joint pain and tinnitus are a daily battle.
The majority of doctors I meet are completely unaware of the danger. My neighbor is an infectious disease specialist. She wrote my last script in fact. Completely clueless until I told her about the havoc the meds she slings around cause ou there.
Educate everyone you know. Tell them about the 2000 lawsuits J&J settled in 2012. Tell doctors. Tell anyone treating a sinus infection. Tell Physical therapists. I don’t make it a pity party: I don’t want anyone suffering the same or worse than I. They know when you sincerely care, and appreciate it immensely.
It’s my chiropractor who knows more about these nightmare drugs than any doctor I have ever met!
Good luck in your fight.
Ryan, do you mind me asking how old you are? You said you had 4 knee surgeries and a total knee. What kind of knee surgeries? Meniscus tears? Did your knees heal after surgery? I’m curious, I have popping, grinding, sand/ gravel feeling in my joints. The pain has spread over the years from my forearms to my shoulders to my knees to my hips to my wrists, ankles, hands, thumb and toes. I have torn ligaments that I am wondering if they will heal if I do surgery. My joints are falling apart. I can’t see how they would heal after surgery but I am going crazy being sedentary. My knees are by far the worst.
Can you elaborate on the 2000 lawsuits J & J settled in 2012?