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Regulator Information
FDA Warning Label – Ciprofloxacin (Cipro)
FDA Warning Label – Levofloxacin (Levaquin)
FDA Warning Label – Moxifloxacin (Avelox)
FDA general warning regarding all fluoroquinolones
11/23/11 Pediatric Advisory Committee Meeting, “Pediatric Focused Safety Review: Levaquin (levofloxacin)”
11/5/15 – Briefing for the FDA’s November 5, 2015 meeting to review “The Benefits and Risks of Systemic Fluoroquinolone Antibacterial Drugs for the Treatment of Acute Bacterial Sinusitis (ABS), Acute Bacterial Exacerbation of Chronic Bronchitis in Patients Who Have Chronic Obstructive Pulmonary Disease (ABECB-COPD), and Uncomplicated Urinary Tract Infections (uUTI)” can be found HERE.
11/5/15 FDA Committee meeting transcript.
FDA Anti-infective Drugs Advisory Committee – 62nd meeting – Development of Fluoroquinolones for Use in Pediatric Patients. (Here is an easier to read link on a Russian site – http://lib.znate.ru/docs/index-121694.html)
European Medicines Agency (EMA) “Public hearing on quinolone and fluoroquinolone medicines – Written interventions received from speaker requests“
EMA Public Hearing on Quinolone and Fluoroquinolone Antibiotics (video)
Media
Contagion Live, “Future of Fluoroquinolones: Risks, Benefits of Antibiotic Workhorse“
Web MD, “Fluoroquinolones Overprescribed Despite Dangers“
Carte Blanche, “Antibiotic Alert” (also on Youtube)
You and Yours (radio show) “Vet ownership, Antibiotic warnings, Online movie reviews“
Nature, “Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA“
Al Jazeera English, “Left paralyzed from Fluoroquinolone antibiotic toxicity“
The Herald Scotland, “The crippling side effects of routinely prescribed antibiotics“
Wall Street Journal, “FDA Requires Stronger Warnings for Antibiotics’ Side Effects“
Washington Post, “It pays to read the warnings when you open up a prescription” and it was re-published in the Hartford Curant as, “Poisoned: The Dramatic Side Effects Of Some Prescription Drugs“
Washington Post, “Prescription for Disaster“
Washington Post, “Postal Workers Sue Maker of Cipro“
New York Times by Jane Brody, “Popular Antibiotics May Carry Serious Side Effects”
New York Times, “Certain Antibiotics May Increase Risk of Birth Defects“
Video / Documentary PBS Frontline expose about fluoroquinolones
The Daily Mail, “Antibiotics got rid of her chest infection – but Jane says they destroyed her health“
The Daily Mail, “Why ARE doctors still doling out antibiotics that have left thousands in crippling pain?“
The Daily Mail, “Common antibiotic doctors say could give you organ failure as millions of Britons are at risk of devastating permanent side effect as a result of over-prescribing“
New Zealand Herald, “Calls for more rules on use of antibiotic“
Business Day South Africa, “Medicines regulator warns of severe side effects of two antibiotics“
Health Europa, “Ciprofloxacin side effects dramatically affect the mitochondrial genome“
KFVS 12 “Potentially dangerous antibiotics“
CBS Local, “Paralyzed By A Prescription: Doctor ‘Poisoned’ By Common Antibiotic“
ABC 15 Arizona, “Experts: Top antibiotic carries hidden side effects not listed on the label” (This story was also run on USA Today, the Detroit Free Press, ABC Detroit, ABC The Indy Channel, NBC West Palm Beach, WCPO Cincinnati, ABC 10 San Diego)
ABC 15 Arizona, “FDA Committee recommends label changes, warnings for popular antibiotics like Cipro, Levaquin”
ABC 15 Arizona, “FDA announces meeting to discuss safety of popular antibiotics like Cipro, Levaquin”
ABC 15 Arizona, “Woman warns of painful side effects from UTI medication“
12 News Arizona, “Be warned: FDA issues new stronger caution about risk of common antibiotics”
WSB TV 2 Atlanta, “Local woman says popular antibiotic killed her husband” (Kathy Dannelly)
WSB TV 2 Atlanta, “Local woman says popular antibiotic killed her husband” (Sandy Davis)
WSB TV 2 Atlanta, “Patients suffer devastating side effects from popular antibiotic”
WSB TV 2 Atlanta, “New calls for stronger warning about popular antibiotic”
WSB TV 2 Atlanta, “New medical research underway on popular antibiotic”
WSB TV 2 Atlanta, “Gwinnett woman to testify about controversial antibiotic”
WSB TV 2 Atlanta, “FDA advisory panel hears from Georgia woman about Levaquin”
WSB TV 2 Atlanta, “Channel 2 investigates Levaquin dangerous side effects”
WSB TV 2 Atlanta, “Clark Howard says near-fatal disease possibly caused by popular antibiotic“
WBZ CBS 4 Boston, “I-Team: Patients Say Popular Drug Caused Devastating Side Effects” and it was also aired on CBS Philly, CBS Sacramento
WBZ CBS 4 Boston, “I-Team: Mass. Families To Share Horror Stories With FDA“
CBS Miami, “Powerful Antibiotic Could Be A Prescription for Danger“
CBS Miami, “Powerful Antibiotic Could Be A Prescription For Danger Pt. II“
Fox Carolina, “FDA releases new warning about common antibiotics”
South Florida Local 10 “Popular antibiotic linked to adverse reactions”
NBC Charlotte, “Devastating side effects prompt local push to ban antibiotic” also shown on KTVE 10 KARD 14 and NBC News and InfoWars and King 5 Seattle and KGW Portland
CBS Sacramento, “Patients Say Popular Antibiotic Caused Devastating Side Effects“
CW6 San Diego, “FDA strengthens warnings on potentially dangerous family of antibiotics”
Eyewitness 3 News CT, “Griswold man sues drug maker over side effects”
KSTP Eyewitness 5 News, “Painful Prescription: Princeton Woman Urges Patients to Research Side Effects” and the follow up story, “FDA Reviewing Warning Labels for Popular Antibiotics”
KSTP Eyewitness 5 News, “FDA Strengthens Warning For Poplar Antibiotics“
CBS Dallas Fort Worth, “Dangerous Antibiotic Could Be Responsible For Deaths“
CBS 11 Dallas, “Rowlett Woman Testifies About Antibiotic Complications“
CBS Los Angeles, “Southland Firefighter Says Popular Antibiotic Poisoned His Body, His Life“
KCTV 5 News Kansas City, “FDA evaluates popular antibiotic that patients say makes them sicker” and it was picked up by 19 Action News in Cleveland
CBS Chicago, “Safety Advocate: Powerful Antibiotics Being Overprescribed“
WSET Virginia, “Popular Antibiotic May Be Causing Permanent Damage“
CBS 4 Denver, “Patients Reporting Serious Adverse Reactions To Popular Antibiotics“
CBS 2 Iowa, “Consumer Alert: Medication Warning“
KCCI Iowa, “Central Iowa family warns about dark side of miracle drug”
KOB 4 Eyewitness News Albuquerque “Common antibiotic linked to serious, potentially-deadly side effects” Part 2 HERE. Part 3 HERE.
NBC News, “FDA warns some antibiotics can cause serious heart damage“
NBC Connecticut, “Prescription Drugs Labels Under Fire“
Metro Philadelphia, “How doctor-prescribed antibiotics left a Philly man disabled“
NBC 2 Fort Myers, “NBC2 Investigators: Thousands call for stronger antibiotic warning“
YLE Areena – News segment in Finnish
WFTS Tampa Bay, “It’s a popular antibiotic, but is it dangerous? Thousands report devastating side effects” also reported on ABC 5 Cleveland and WPTV Palm Beach
WFTS Tampa Bay, “Powerful and popular antibiotic sometimes comes without warning:
Adverse side effects and be devastating”
Click 2 Houston, “Thousands of adverse reactions reported from common antibiotics” and it was also aired in Orlando.
Bay News 9, “FDA Warns Cipro, Levaquin May Increase Aneurysm Risk“
CNN, “Certain antibiotics may cause aortic aneurysm, FDA warns“
ABC 8 News Richmond WRIC, “Commonly prescribed antibiotics can cause potentially deadly ruptures, FDA warns”
ABC 8 News Richmond WRIC, ““Cipro had fried her liver”: Virginia woman says common antibiotic killed her mother”
ABC 8 News Richmond WRIC, “8News Investigates: Could this antibiotic permanently damage your health?” and PART 2
ABC 8 News Richmond WRIC, “Doctors left in dark about prescription drug dangers”
ABC 8 News Richmond WRIC, “FDA to hear patient complaints about commonly prescribed antibiotics”
ABC 8 News Richmond WRIC, “Patients share horror stories from commonly used antibiotics” It was also shared on WIAT.com.
ABC 8 News Richmond WRIC, “Federal lawsuit filed against former FDA Commissioner”
ABC 8 News Richmond WRIC, “FDA issues new label changes for common antibiotics”
ABC 8 News Richmond WRIC, “FDA warns of mental health risks linked to commonly prescribed antibiotics”
WSOCTV Charlotte, “Action 9: Some blame certain antibiotics for devastating side effects”
WSOCTV Charlotte, “Update: FDA to hear from patients about possible side effects of antibiotics”
WSOCTV Charlotte, “Charlotte woman urges senators to police FDA better”
WSOCTV Charlotte, “FDA changes warning label on popular antibiotics“
WSOCTV Charlotte, “Some worry doctors don’t know about new warnings on some antibiotics”
CBS San Francisco, “Patients Call For Strong FDA Warning After Complications From Popular Antibiotics Reported“
KJRH Tulsa, “Levaquin: FDA fails to disclose additional serious side effects of antibiotic linked to deaths” and “Man warns those considering Levaquin of dangerous possible side effects”
Newsnet 5 Cleveland, “Levaquin: FDA fails to disclose additional serious side effects of antibiotic linked to deaths.“
ABC Action News WFTS, “Popular and powerful antibiotic label fails to list all of the severe side effects.”
ABC Action News, “The worst side effects of one of the most popular antibiotics is buried in fine print“
ABC Action News WFTS, “FDA warns antibiotic can cause fatal heart damage“
San Diego ABC 10, “Levaquin: FDA fails to disclose additional serious side effects of antibiotic linked to deaths”
RTV 6, “CALL 6 Investigates: Patients raise concerns about powerful antibiotics”
RTV 6, “CALL 6: Mother blames antibiotic for son’s death“
Fox 25 Boston, “FOX25 Investigates: Some blame certain antibiotics for devastating side effects“
Fox 25 Boston, “Fighting Dangerous Antibiotics.”
Fox 13 Memphis, “FOX13 Investigates: Powerful antibiotics with potential for danger“
WJZ CBS Baltimore, “Patients Want Drug Off The Market Following Crippling Side Effects“
WMAR Baltimore, “FDA holds meeting to discuss Levaquin, other fluoroquinolone side effects”
WMAR Baltimore, “FDA advisory committee vote could spark changes in Levaquin, Cipro labeling”
WMAR Baltimore, “Overprescription of antibiotics creating resistance, while patients endure unnecessary side effects”
WMAR Baltimore, “FDA advises use of Cirpo and Levaquin be restricted“
WSOC Charlotte, “FDA to hear from patients about possible side effects of antibiotic”
TMJ4, “I-Team Investigation: Antibiotic side effects that could damage your health“
TMJ4, “FDA adds more warnings to popular antibiotics“
WRTV 6 The Indy Channel, “FDA announces antibiotic label changes following Call 6 report“
WRTV 6 The Indy Channel, “Drug maker stopped making popular antibiotic Levaquin amid concerns about mental health side effects“
New Jersey News 12, “Kane in Your Corner: Did FDA wait too long to warn about popular antibiotic Levaquin?“
KETV 7 Omaha, “Runners warn of getting ‘floxed’ following FDA warning on antibiotics“
Times Union, “Quinolone or Stand Alone?“
CBS News video, Antibiotics May Damage Human Tissues and Cells
CBS News, “Class of antibiotics gets stronger warning due to dangerous side effects“
Forbes, “Antibiotic Alert: The Drug the Doctor Ordered Could Cause Deadly Side Effects”
Forbes, “Yet Another Warning On Fluoroquinolone Antibiotic Side Effects“
Forbes, “FDA Warns About What Fluoroquinolone Antibiotics May Do To Your Aorta“
Mother Jones, “My Big Levaquin Adventure“
The Vancouver Sun, “Popular antibiotics implicated in nerve damage, says study with B.C. links“
Articles from Dr. Mercola about fluoroquinolones
Antiobiotic Alert: The Drug the Doctor Ordered Could Cause Deadly Side Effects
Warning: Fluoroquinolone Antibiotics May Cause Permanent Nerve Damage
Video / Documentary specifically about Fluoroquinolone Toxicity – Certain Adverse Events. It is also available on Youtube.
Book – Bitter Pills: Inside the Hazardous World of Legal Drugs by Stephen Fried
Prohealth, by Jason Alexander Uttley, “The Poisoning of America: The Rise of “Mystery” Illnesses Including Chronic Fatigue Syndrome, Fibromyalgia and Gulf War Syndrome”
News piece on Youtube about fluoroquinolones, also called “Bitter Pills” (though not related to the book, I believe).
Wall Street Journal, “Surge in Use of Cipro Spurs Concerns About Side Effects”
Wall Street Journal, “Lingering Pain from the Anthrax Attacks: Cipro Side Effects“
Wall Street Journal, “FDA Panel Seeks Tougher Antibiotic Labels” and Business Insider picked up the story – “We’re finding out more and more about the risks of a common medicine once considered a wonder drug“
The Ecologist article by Andrew Wasley, “Popular Antibiotic Ciprofloxacin Linked to UK Deaths.”
Medline Plus article by Robert Preidt, “Certain Antibiotics Tied to Blood Sugar Swings”
News@JAMA, “Fluoroquinolones Pose Blood Sugar Risks for People With Diabetes“
Health Day, “Certain Antibiotics Tied to Blood Sugar Swings in Diabetics“
Point of Return, Description of Effects of Fluoroquinolones
Article in The Air Force Times: New FDA Warnings on Cipro May tie into Gulf War Illness
Science Daily, “Risk of Kidney Disease Doubled with use of Fluoroquinolone Antibiotics”
Science Daily, “Ciprofloxacin has dramatic effects on the mitochondrial genome“
US News and World Reports, by Steven Reinberg, “Antiobiotics Linked to Retinal Detachment Risk: The Risk is Very Small and the Reasons aren’t Known, Researchers Say”
US News and World Reports, by Michael Schroeder, “Could Taking That Antibiotic Have Serious, Long-Term Consequences?“
Fox News, “Common Antibiotics Tied to Eye Emergencies Study Says”
News@JAMA, by Mike Mitka “Retinal Detachment Risk Associated with Use of Some Antibiotics”
The Vancouver Sun, “Popular antibiotics to carry new warning about retinal detachment“
Dear Doctor letter written by Dr. Plumb, a doctor who was Floxed
Dear Doctor letter by Miriam J. de Jong M.D.
Drug Safety Monitor, “Study Shows that Moxifloxacin Associated with High Rates of Hospitalizations Due to Drug Reactions”
European Journal of Clinical Microbiology and Infectious Diseases, “Quinolone antimicrobial agents: Adverse effects and bacterial resistance“
Journal of Clinical Neuromuscular Disease, “Carpal tunnel syndrome after Ciprofloxacin-induced tendinitis“
Mail Online, “Taking Antibiotics Ruptured my Tendon: The Hidden Dangers of Everyday Drugs we Assume are Harmless“
Diabetic Medicine, “Levofloxacin-associated hypoglycaemia complicated by pontine myelinolysis and quadriplegia.“
Medscape Medical News, “New Evidence of Dysglycemia with Gatifloxacin“
New England Journal of Medicine, “Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults“
Medscape MultiSpecialty, “Antibiotics and Neuropathy: What’s the Latest?“
Medscape MultiSpecialty, “Safety of the Fluoroquinolone Antibiotics: Focus on Molecular Structure”
Medscape MultiSpecialty, “Limit Fluoroquinolone Use in Light of Risks, FDA Says“
Medscape, “More Fluoroquinolone Safety Concerns“
Egyptian Newspaper article about FQs, in Arabic “Antibiotics: A Two Edged Sword“
Natural News, “Magnesium Heals Cipro Damage“
News Inferno, “Study: Fluoroquinolone-Cortisteroid Combo Increases Adverse Effects“
Boise Weekly, “The Cure that Kills: When the Side-Effects of Medications are Worse Than the Ailments They’re Prescribed For“
Medscape Heartwire, “Cardiac Risks with Antibiotics Azythromycin, Levofloxacin Supported by VA Data“
JAMA Internal Medicine, “Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone“
Baylor College of Medicine, “Ciprofloxacin increases risk of tears, rupture in mouse aortas“
BMJ, “Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study“
Chiropractic & Manual Therapies, “Spontaneous cervical artery dissection: a fluoroquinolone induced connective tissue disorder?“
BMJ, “Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study“
Oklahoma’s NewsOn6, “Broken Arrow Woman Deals with Medication Side-Effects 1 Year Later“
Green Med Info, “Fluoroquinolone Antibiotics Linked To Severe Liver Damage“
Los Angeles Times, “Downside of Widespread Cipro Use“
Salon, “In Cipro We Trust“
AZ Central, “Critics demand stronger warnings for potent antibiotics“
The People’s Chemist, “Drug Rep Exposes Antibiotics: Risks Outweigh Benefits, You Have Alternatives“
Nursing Link, “Clinically Significant Drug Interaction with the Cytochrome P450 Enzyme System”
The Legal Examiner, “Connecting the dots: Reasons why fluoroquinolones such as Levaquin destroy connective tissue matrices found in tendons all over the body”
Cape Breton Post, “Antibiotics linked to kidney damage: study”
David Perlmutter, MD, “Fluoroquinolones and Peripheral Neuropathy“
Emergency Medicine News, “Adverse Reactions to Fluoroquinolones“
Academic Life in Emergency Medicine, “Beware of fluoroquinolones: You, your patient, and the FDA“
Counterpunch, “The Ignored Risks of Fluoroquinolones“
2 Minute Medicine, “Fluoroquinolones linked with risk of aortic dissection and aneurysm“
ID Week, “Fluoroquinolones Are Overprescribed for Routine Urinary Tract Infections“
Star Tribune, “Former Edina band director faces health challenge with grace“
Tech Times, “Fluoroquinolones Need Stronger Warnings About Side Effect Risks, Says FDA Panel“
Medscape Medical News, “FDA Panel Says Fluoroquinolones Need Stronger Warnings“
Medpage Today, “Evidence Lacking for Some Fluoroquinolone Use–FDA panel says risk-benefit data don’t support current labeling“
Medpage Today, “FDA Warns on Aortic Aneurysms With Fluoroquinolones – Adds to already long list of issues with popular antibiotic class“
KSTP ABC 5, “FDA Committee: Better Safety Warnings Needed for Popular Antibiotic”
The Times of India, “Widely-prescribed antibiotics need stronger warnings: USFDA panel“
MPR, “Fluoroquinolones Linked to More Than Tendon Ruptures“
Medium.com, “Fluoroquinolones: An FDA advisory panel urge drug companies for clearer and prominent label warnings on side effects“
About Health, “Fluoroquinolone Antiobiotics and Your Thyroid Medication: Interactions“
Fox 2 Detroit, “Monroe woman who suffered Levaquin drug side effects ‘wanted to die'”
Consumer Reports, “Fluoroquinolones Are Too Risky for Common Infections“
Consumer Reports, “Make Sure Your Doctor Prescribes the Right Antibiotic: There are safer, better options than fluoroquinolones and other frequently prescribed broad-spectrum drugs“
Consumer Reports, “Meds That Cause Blurred Vision, Hearing Loss, and More: Painkillers, antibiotics, and other common drugs can trigger surprising side effects“
Consumer Reports, “Surprising Remedy for Deadly Hospital Infections: New study suggests doctors cut back on antibiotics. Here’s what you need to know.“
Huffington Post, “Why the FDA’s New Warning Labels for Popular Antibiotics Matter“
Runner’s World, “FDA Warns of Tendon Damage Linked to Antibiotics“
The Facts, “WHEN THE CURE IS WORSE: Lake Jackson woman reaches out about danger of prescription drugs“
AAP News, “AAP report details use of fluoroquinolones in children“
Snopes, “Could Cipro and Other Fluoroquinolone Antibiotics Cause Irreversible Tendon Damage?“
BenzoInfo.com, “Hidden Dangers of Fluoroquinolone Antibiotics in the Benzodiazepine-Dependent Population“
Stern (German Publication), “Why you should be aware of these antibiotics“
New Zealand Herald, “Kiwi surfing legend Bob Davie’s family speaks out on fluoroquinolones, the medication they believe caused his suicide“
The Pharmaceutical Journal, “EMA confirms suspension or restriction of quinolone and fluoroquinolone antibiotics”
Courthouse News Services, “Doc Claims Bayer|Falsified Cipro Data“
Research
“Treatment of the Fluoroquinolone Associated Disability – the pathobiochemical implications“
Journal of American Medicine (JAMA), “New Fluoroquinolone Warning“
Journal of American Medicine (JAMA), “Fluoroquinolone Use and Concern About the Cerebral Vasculature“
British Journal of Medicine (BMJ), “Fluoroquinolone-induced serious, persistent,
multisymptom adverse effects“
Mechanisms in Medicine, video, “Fluoroquinolones: Mechanisms of Action and Resistance”
Medication Sense articles by Jay S. Cohen, M.D.
- New Warnings for Cipro, Levaquin, and other Quinolone Antibiotics
- Peripheral neuropathy associated with fluoroquinolones
- Reactions to Cipro, Levaquin, and Other Fluoroquinolone Antibiotics
- Fluoroquinolone Toxicity Syndrome: A Letter to the Senate Committee on Health, Education & Labor
- New Warnings for Cipro, Levaquin, and other Quinolone Antibiotics
- Severe Reactions to Levaquin, Cipro and Other Fluoroquinolone Antibiotics: Are Doctors in Denial?
Chiropractic and Manual Therapies, “Spontaneous cervical artery dissection: a fluoroquinolone induced connective tissue disorder?“
Chemotherapy, “History of Quinolones and Their Side Effects“
Journal of Medicinal Chemistry, “Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity.”
ACS Publications, “Examining the Impact of Antimicrobial Fluoroquinolones on Human DNA Topoisomerase IIα and IIβ“
Chemico-Biological Interactions, “Relationship of cellular topoisomerase IIα inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells.“
Therapeutics and Clinical Risk Management, “Personalized therapeutics for levofloxacin: a focus on pharmacokinetic concerns“
Mutagenesis, “Type II topoisomerases—inhibitors, repair mechanisms and mutations“
Journal of Pharmacy & Pharmaceutical Sciences, “Nonclassical biological activities of quinolone derivatives.”
The Journal of Biological Chemistry, “The Mechanism of Inhibition of Topoisomerase IV by Quinolone Antibacterials.”
Clinical Chemistry, “Interference of Ofloxacin with Determination of Urinary Porphyrins“
Antimicrobial Agents and Chemotherapy, “Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.“
Nucleic Acids Research, “Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2“
Nucleic Acids Research, “The DNA cleavage reaction of topoisomerase II: wolf in sheep’s clothing“
Antimicrobial Agents and Chemotherapy, “Effect of Levofloxacin on Glycosaminoglycan and DNA Synthesis of Cultured Rabbit Chondrocytes at Concentrations Inducing Cartilage Lesions In Vivo“
The Journal of Biological Chemistry, “Mechanism of Quinolone Action
A DRUG-INDUCED STRUCTURAL PERTURBATION OF THE DNA PRECEDES STRAND CLEAVAGE BY TOPOISOMERASE IV“
Mutation Research, “Recombinagenic and mutagenic activities of fluoroquinolones in Drosophila melanogaster.“
Proceedings of the National Academy of Sciences of the United States, Biochemistry, “Quinolone Binding to DNA Mediated by Magnesium Ions”
Austin Journal of Computational Biology and Bioinformatics, “Combination of Molecular Modeling and Quantum Mechanical Studies to Understand Quinolone Resistance Mechanism of Mycobacterium Tuberculosis“
Antimicrobial Agents and Chemotherapy, “Effect of magnesium complexation by fluoroquinolones on their antibacterial properties.“
Mutation Research, “Ciprofloxacin: Mammalian DNA Topoisomerase Type II Poison In Vivo“
International Journal of Developmental Neuroscience, “Analysis of age dependent changes of Topoisomerase II alpha and beta in rat brain.“
Toxicology Mechanisms and Methods, “Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms.“
Journal of Neurosurgery, “Abnormal coagulation studies associated with levofloxacin. Report of three cases.“
Annals of Epidemiology, “Peripheral Neuropathy and Guillain-Barre Syndrome Risks Associated with Exposure to Systemic Fluoroquinolones: A Pharmacovigilance Analysis“
Journal of Investigative Medicine HIGH IMPACT CASE REPORTS, “Permanent Peripheral Neuropathy
A Case Report on a Rare but Serious Debilitating Side-Effect of Fluoroquinolone Administration”
Neurology Today, “New Support for Association Between Fluoroquinolones and Peripheral Neuropathy“
Clinical Infectious Diseases, “Temafloxacin Syndrome: Review of 95 Cases”
Drug Safety, “The withdrawal of temafloxacin. Are there implications for other quinolones?“
BMJ, “Ciprofloxacin interacts with thyroid replacement therapy“
The British Journal of General Practice, “Benzodiazepine tolerance, dependency, and withdrawal syndromes and interactions with fluoroquinolone antimicrobials“
The British Journal of Clinical Pharmacology, “Possible interaction of fluoroquinolones with the
benzodiazepine-GABAA-receptor complex“
Antimicrobial Agents and Chemotherapy, “Ciprofloxacin and sparfloxacin penetration into human brain tissue and their activity as antagonists of GABAA receptor of rat vagus nerve.“
African Journal of Pharmacy and Pharmacology, “Evaluation of the effects of ciprofloxcin or gatifloxacin on neurotransmitters levels in rat cortex and hippocampus“
Antimicrobial Agents and Chemotherapy, “Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor.”
Pharmacology Weekly, “What is the mechanism by which the fluoroquinolone antibiotics (e.g., ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin) can increase a patient’s risk for developing a seizure or worsen epilepsy?“
Annals of Pharmacotherapy, “Seizure with ciprofloxacin and theophylline combined therapy.“
Livewello, “Levofloxacin and Risk Of Seizures“
Journal of Antimicrobial Chemotherapy, “The effects of quinolones and NSAIDs upon GABA-evoked currents recorded from rat dorsal root ganglion neurones“
European Journal of Pharmacology, “Effects of quinolone carboxylic acid derivatives on GABAA receptor-mediated stimulation of gastric acid secretion and intestinal motility.“
Neuropharmacology, “A Patch Clamp Study of the Effects of Ciprofloxacin and Biphenyl Acetic Acid on Rat Hippocampal Neurone GABA, and Ionotropic Glutamate Receptors.“
Drug Safety, “Potential Interactions of the Extended-Spectrum Fluoroquinolones with the CNS“
Turkish Journal of Hemotology, “Ciprofloxacin: A Novel Therapeutic Agent for Iron Overload?“
Antimicrobial Agents and Chemotherapy, “The Fluoroquinolone Levofloxacin Triggers the Transcriptional Activation of Iron Transport Genes That Contribute to Cell Death in Streptococcus pneumoniae“
Journal of Biological Chemistry “Non-antibiotic effects of fluoroquinolones in mammalian cells.“
Renal Failure, “Ciprofloxacin-Induced Acute Interstitial Nephritis and Autoimmune Hemolytic Anemia“
Case Reports in Infectious Diseases, “Autoimmune Hemolytic Anemia Induced by Levofloxacin“
Antimicrobial Agents and Chemotherapy, “Levofloxacin and Moxifloxacin Increase Human Gut Colonization by Candida Species.“
BMC Microbiology, “Comparative Transcription Analysis and Toxin Production of Two Fluoroquinolone-Resistant Mutants of Clostridium Perfringens” FDA write-up
Current Medicinal Chemistry, “Recent Advances in the Discovery and Development of Quinolones and Analogs as Antitumor Agents”
Urology, “Quinolone antibiotics: a potential adjunct to intravesical chemotherapy for bladder cancer“
International Journal of Oncology, “Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC“
British Journal of Cancer, “Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells“
Journal of Photochemistry and Photobiology, “Structure–activity relationship and role of oxygen in the potential antitumour activity of fluoroquinolones in human epithelial cancer cells“
Cancer Epidemiological Biomarkers, “Infant Leukemia: Finding the Needle in the Haystack“
Archive of Pharmacology, “From chloroquine to antineoplastic drugs? The story of antibacterial quinolones“
Asian Pacific Journal of Cancer Prevention, “Comparative Evaluation of Antiproliferative Activity and
Induction of Apoptosis by some Fluoroquinolones with a Human Non-small Cell Lung Cancer Cell Line in Culture“
Biochemical Pharmacology, “Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways“
Cell Science at a Glance, “Lysosomal cell death at a glance“
Toxicological Sciences, “Inhibition of Human Topoisomerase IIa by Fluoroquinolones and Ultraviolet A Irradiation“
Experimental Gerontology, “DNA topoisomerases in mtDNA maintenance and ageing”
Antimicrobial Agents and Chemotherapy, “Modulation of Gyrase-Mediated DNA Cleavage and Cell Killing by ATP“
Nature, “Unexpected Link Between and Antibiotic, Pannexin Channels and Apoptosis“
Cancer Biol. Ther., “Ciprofloxacin-induced G2 arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation”
The Journal of Biological Chemistry, “Cytotoxicity of Quinolones toward Eukaryotic Cells: Identification of Topoisomerase II as the Primary Cellular Target for the Quinolone CP-115,953 in Yeast“
Inorganic Chemistry, “New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium.“
Journal of Physiology and Pharmacology, “Ciprofloxacin Inhibits Proliferation and Promotes Generation of Aneuploidy in Jurkat Cells“
Nepal Medical College Journal, “Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro”
Journal of Applied Toxicology, “Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells“
Toxicology and Applied Pharmacology, “The effects of levofloxacin on rabbit fibroblast-like synoviocytes in vitro.“
Antimicrobial Agents and Chemotherapy, “Ciprofloxacin Induces an Immunomodulatory Stress Response in Human T Lymphocytes“
Journal of Leukocyte Biology, “Several Gene Programs are Induced in Ciprofloxacin Treated Human Lymphocytes as Revealed by Microarray Analysis”
Archives of Toxicology, “A Comparative Analysis of Chromosomal Abberations in Cultured Human Lymphcytes Due to Fluoroquinolone Drugs at Different Expression Periods“
Food Additives and Contaminants, “Antibodies to the quinolones and fluoroquinolones for the development of generic and specific immunoassays for detection of these residues in animal products.“
Oxford Journals, “Specific Toxicologic Aspects of the Quinolones”
Science Translational Medicine, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells”
Toxicology Mechanisms and Methods, “Toxicity of Broad Spectrum Antibacterials in Normal Rat Liver: The Role of Mitochondrial Membrane Permeability Transition Pore.”
Cell, “A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics“
Molecular Systems Biology, “Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli“
Medical Science Monitor, “Toxic Effects of Levofloxacin on Rat Annulus Fibrosus Cells: An In-vitro Study“
Free Radical Research, “The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells“
Toxicologic Pathology, “Histological Examination on Achilles Tendon Lesions Induced by Quinolone Antibacterial Agents in Juvenile RatsF”
QJM, “Achilles is Not Alone!!! Ciprofloxacin Induced Tendinopathy of Gluteal tendons“
BMC Complimentary & Alternative Medicine, “TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells”
African Journal of Pharmacy and Pharmacology, “Effect of ciprofloxacin and levofloxacin
on some oxidative stress parameters in brain regions of male albino rats“
Antimicrobial Agents and Chemotherapy, “Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components“
Wyss Institute for Biologically Inspired Engineering at Harvard University, “Dodging Antibiotic Side Effects”
Journal of Advanced Pharmacy Education and Research, “Fluoroquinolone Induced Neurotoxicity: A Review“
American Journal of Pharmacology and Toxicology, “CIPROFLOXACIN INDUCED CHONDROTOXICITY AND TENDINOPATHY“
Journal of Toxicology and Environmental Health, “Toxicity of quinolone antimicrobial agents“
The Ultrasound Site UK, “Fluoroquinolone Induced Achilles Tendinopathy“
Antimicrobial Agents & Chemotherapy, “Diminished Ciprofloxacin-Induced Chondrotoxicity by Supplementation with Magnesium and Vitamin E in Immature Rats“
Current Microbiology, “Ciprofloxacin-Induced Antibacterial Activity is Reversed by Vitamin E and Vitamin C“
Archives of Toxicology, “Ciprofloxacin Causes Cytoskeletal Changes and Detachment of Human and Rat Chondrocytes in Vitro“
Journal of Bone and Joint Surgery, “Fluoroquinolone’s effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation.”
Veterinary Pathology, “In Vitro Evidence of Effects of Magnesium Supplementation on Quinolone Treated Horse and Dog Condrocytes“
Veterinary and Human Toxicology, “Serum sickness secondary to ciprofloxacin use.”
Academic Journals, “Toxicology of Baytril“
Antimicrobial Agents and Chemotherapy, “Serum sickness-like illness associated with ciprofloxacin.“
Archives of Toxicology, “Integrins on Joint Cartilage Chondrocytes and Alterations by Ofloxacin or Magnesium Deficiency in Immature Rats“
European Journal of Cell Biology, “Integrins Mediate the Effects of Quinolones and Magnesium Deficiency on Cultured Rat Chondrocytes“
Journal of Pharmacology and Experimental Therapeutics, “Effects of fluoroquinolones on cultured articular chondrocytes flow cytometric analysis of free radical production“
Antimicrobial Agents and Chemotherapy, “Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.”
Nature Reviews: Microbiology, “How Antibiotics Kill Bacteria: From Targets to Networks“
Nature, “Topoisomerases Facilitate Transcription of Long Genes Linked to Autism” (Note that Fluoroquinolones are topoisomerase interrupters and I wrote this post about the Nature article – http://www.collective-evolution.com/2013/09/18/a-horrifying-cause-of-autism-dna-damage-from-synthetic-antibiotics/)
Journal of Neurosciences in Rural Practices, “Levofloxacin Induced Acute Anxiety and Insomnia”
BMJ Clinical Research, “Drug Points: Sleep disturbance in children treated with ofloxacin“
Antimicrobial Agents and Chemotherapy, “Effects of Novel Fluoroquinolones on the Catalytic Activities of Eukaryotic Topoisomerase II: Influence of the C-8 Fluorine Group“
Chemistry and Biology, “Trovofloxacin, a Fluoroquinolone Antibiotic with Hepototoxic Potential, Causes Mitochondrial Peroxinitrate Stress in a Mouse Model of Underlying Mitochondrial Dysfunction“
Journal of Pharmacology, “Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response“
Current Medicinal Chemistry, “The quinolone family: from antibacterial to anticancer agents.“
Drug Metabolism and Disposition, “Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells“
The Journal of Antibiotics, “Modulation of Salmonella gene expression by subinhibitory concentrations of quinolones“
Molecular Pharmacology, “Delayed Cytotocicity and Cleavage of Mitochondrial DNA in Ciprofloxacin Treated Mammalian Cells”
MIT Media Relations, “Pinpointing How Antibiotics Work”
European Journal of Medicinal Chemistry, “Antibacterial Action of Quinolones: From Target to Network“
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, “Damage to Mitochondrial DNA Induced by the Quinolone Bay y 3118 in Embryonic Turkey Liver”
Molecular Nutrition and Food Research, “Medication Induced Mitochondrial Damage and Disease” (Note that this article is about drug induced mitochondrial damage generally, not about fluoroquinolones specifically.)
Alternative and Complimentary Therapies, “Mitochondria and Disease – What Clinicians Need to Know and Why” (Also about mitochondria generally – and the author didn’t get his note about what antibiotics damage mitochondria right, but it’s still a decent article.)
Cleveland Clinic Journal of Medicine, “Mitochondrial cytopathy in adults: What we know so far“
CSH Perspectives, “The Maintenance of Mitochondrial DNA Integrity—Critical Analysis and Update“
Biochim Biophys Acta, “Mitochondrial DNA Damage and its Consequences for Mitochondrial Gene Expression“
Toxicology and Applied Pharmacology, “Mitochondrial abnormalities–a link to idiosyncratic drug hepatotoxicity?“
Antimicrobial Agents and Chemotherapy, “Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components“
Antimicrobial Agents and Chemotherapy, “Effects of New Quinolones on Transepithelial Electrical Potential Difference of Tracheal Mucosa In Vivo“
Reproductive Sciences, “Role of Mitochondria in Ciprofloxacin-Induced Apoptosis in Murine Sperm Cells“
American Physiological Society, “Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production“
Molecular Neurodegeneration, “Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases“
Toxicological Sciences, “Review: Mitochondria as a Target of Environmental Toxicants“
Environmental Toxicology and Chemistry, “Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater“
Human Molecular Genetics, “Mitochondrial dynamics – fusion, fission, movemente, and mitophagy – in neurogenerative diseases“
Journal of Antimicrobial Chemotherapy, “Peripheral Sensory Disturbances Related to Treatment with Fluoroquinolones”
The Canadian Journal of Infectious Diseases, “Safety of Fluoroquinolones: An Update“
Clinical and Experimental Allergy, “T Cell Mediated Hypersensitivity to Quinolones: Mechanisms and Cross-Reactivity” delayed reactions
Journal of Pharmacotherapy & Pharmacotherapeutics, “Cross sensitivity between ciprofloxacin and levofloxacin for an immediate hypersensitivity reaction“
Clinical Infectious Diseases, “Quinolone Arthropy in Animals vs. Children” (When you see the conclusion that these drugs are safe for children, please take into consideration that the study was commissioned by Pfizer.)
BMJ Case Studies, “Fluoroquinolone Use in a Child Associated with Development of Osteochondritis Dissecans“
Toxicology and Applied Pharmacology, “TNF/TNFR1 pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes“
The Journal of Immunology, “Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression: Mechanism of Ciprofloxacin Mediated Immunosuppression“
Antimicrobial Agents and Chemotherapy, “Calcium Signals are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA Content in Jurkat Cells“
Muscle & Nerve, “Fluoroquinolones influence the intracellular calcium handling in individuals susceptible to malignant hyperthermia.“
Molecular Systems Biology, “Gyrase Inhibitors Induce an Oxidative Damage Cellular Death Pathway in Escherichia Coli“
Clinical Infectious Diseases, “Risk of Severe Dysglycemia Among Diabetic Patients Receiving Levofloxacin, Ciprofloxacin, or Moxifloxacin in Taiwan“
BMJ, “Diabetes Inspidus Induced by Ofloxacin“
Medical Hypotheses, “Fluoroquinolone antibiotics and type 2 diabetes mellitus“
British Journal of Pharmacology, “Increase in insulin release from rat pancreatic islets by quinolone antibiotics.“
European Journal of Pharmaceutical Sciences, “Effect of fluoroquinolones on mitochondrial function in pancreatic beta cells.“
The Annals of Pharmacotherapy, “Safety Concerns with Fluoroquinolones“
Canadian Medical Association Journal, “Risk of Acute Kidney Injury Associated With the Use of Fluoroquinolones”
American Journal of Kidney Diseases, “Levofloxacin-induced granulomatous interstitial nephritis.”
Toxicology Letters, “Disturbance of Cellular Glucose Transport by Two Prevalently Used Fluoroquinolone Antibiotics Ciprofloxacin and Levofloxacin Involves Glucose Transporter Type 1”
The Journal of the American Medical Association (JAMA), “Oral Fluoroquinolones and the Risk of Retinal Detachment”
Clinical Infectious Diseases, “Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study.“
Journal of Rheumatology, “Malignant hyperthermia susceptibility revealed by myalgia and rhabdomyolysis during fluoroquinolone treatment.”
Intensive Care Medicine, “Moxifloxacin-induced rhabdomyolysis“
Annals of Pharmacotherapy, “Acute Rhabdomyolysis Associated with Ofloxacin/Levofloxacin Therapy“
BMJ Case Reports, “Ciprofloxacin and statin interaction: a cautionary tale of rhabdomyolysis.”
Canadian Journal of Clinical Pharmacology, “RHABDOMYOLYSIS DUE TO AN UNCOMMON INTERACTION OF CIPROFLOXACIN WITH SIMVASTATIN“
Antimicrobial Agents and Chemotherapy, “Effects of Ciprofloxacin and Ofloxacin on Adult Human Cartilage In Vitro“
Physical Medicine and Rehabilitation (PM & R) “Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population“
The Journal of Clinical and Aesthetic Dermatology, “The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture: What Does The Clinician Need To Know?“
Journal of the American Board of Family Medicine, “Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature“
Clinical Update, “Drug induced muscle disorders“
Chang Gung Medical Journal, “Fluoroquinolone-associated Tendinopathy“
The American Journal of Sports Medicine, “Fluoroquinolones Impair Tendon Healing in a Rat Rotator Cuff Repair Model – A Preliminary Study“
Toxicologic Pathology, “Toxic Effects of Quinolone Antibacterial Agents on the Musculoskeletal System in Juvenile Rats“
Drugs Under Experimental and Clinical Research, “Possible involvement of nitric oxide in the quinolone-induced tendon lesions in rats.“
Antimicrobial Agents and Chemotherapy, “Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to Collagen“
Physical Therapy, “Physical Therapist Management of Fluoroquinolone-Induced Achilles Tendinopathy“
Antimicrobial Agents and Chemotherapy, “Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 fluoroquinolones and effects of anti-inflammatory compounds.“
BMC Ophthalmology, “Effect of topical fluoroquinolones on the expression of matrix metalloproteinases in the cornea“
Current Pharmaceutical Design, “Hypersensitivity Reactions to Ophthalmic Products“
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, “Deciphering the pathogenesis of tendinopathy: a three-stages process”
Journal of Antimicrobial Chemotherapy, “Contribution of Reactive Oxygen Species to Pathways of Quinolone Mediated Bacterial Cell Death“
The American Journal of Sports Medicine, “The Effect of Ciprofloxacin on Tendon, Paratenon, and Capsular Fibroblast Metabolism“
The Tohoku Journal of Experimental Medicine, “Fluoroquinolone Induced Tendinopathy: Etiology and Preventative Measures“
Clinical Infectious Diseases, “Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature“
International Journal of Antimicrobial Agents, “Synergystic Effects of Dexamethasone and Quinolones on Human Derived Tendon Cells“
Antimicrobial Agents and Chemotherapy, “Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium Deficient Diet“
Laboratorie de Toxicologie, “In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress“
Arthritis and Rheumatism, “Ciprofloxacin Mediated Cell Proliferation Inhibition and G2 M Cell Cycle Arrest in Rat Tendon Cells”
BMJ, “FDA adds “black box” warning label to fluoroquinolone antibiotics“
Journal of Young Pharmacists, “Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients“
Drug and Chemical Toxicology, “Ciprofloxacin‐Induced Glutathione Redox Status Alterations in Rat Tissues“
Journal of Hazardous Materials, “Oxidative stress response of two fluoroquinolones with catalase and erythrocytes: a combined molecular and cellular study.”
International Science Index, “Effects of Ciprofloxacin and Levofloxacin Administration on Some Oxidative Stress Markers in the Rat“
Molecular Degeneration, “Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases“
Chemotherapy, “Fleroxacin Enhancement of Superoxide Production by Polymorphonuclear Leukocytes: The Role of Protein Kinases“
Archives of Biochemistry and Biophysics, “Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents“
Photodermatology, Photoimmunology & Photomedicine, “Photolocalized purpura during ciprofloxacin therapy.“
Toxicology Letters, “Mechanisms of quinolone phototoxicity“
Nucleic Acids Research, “DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib“
Dermatology Online Journal, “Stasis Dermatitis as a Complication of Recurrent Levofloxacin-Associated Bilateral Leg Edema“
Drug Metabolism and Disposition, “Acyl Glucuronidation of Fluoroquinolone Antibiotics by the UDP-Gulucuronosyltransferase 1A Subfamily in Human Liver Microsomes“
Current Drug Metabolism, “Acyl Glucuronides: Mechanistic Role in Drug Toxicity?“
Expert Opinion on Drug Metabolism & Toxicology, “Metabolic activation of carboxylic acids“
Molecular Interventions, “Mechanisms of Pathogenesis in Drug Hepatoxicity Putting the Stress on Mitochondria“
Medical Hypotheses, “Epigenetic side-effects of common pharmaceuticals: A potential new
field in medicine and pharmacology“
African Journal of Pharmacy and Pharmacology, “Ultra structural study of gentamicin and ofloxacin effect
on testis tissue in rats: Light and transmission electron microscopy“
Chemico-biological Interactions, “Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction.”
American Journal of Health-System Pharmacy, “Risk of hepatotoxicity associated with fluoroquinolones: A national case-control safety study“
The Journal of Pharmacology, “In Vetro Discrimination of Fluoroquinolones on Tendon Cells: Involvement of Oxidative Stress”
Journal of Pharmacy Practice, “What Role do Fluoroquinolone Antimicrobial Agents Play in Cardiac Dysfunction and Altered Glycemic Control?“
Annals of Family Medicine, “Azithromycin and Levofloxacin Use and Increased Risk of Cardiac Arrhythmia and Death“
Journal of Antimicrobial Chemotherapy, “Quinolone-induced QT interval prolongation: a not-so-unexpected class effect“
Journal of Cardiovascular Electrophysiology, “Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.“
Emergency Medicine News, “Adverse Reactions to Fluoroquinolones”
Journal of Antimicrobial Chemotherapy, “Mechanisms of quinolone action and microbial response“
BMC Infectious Diseases, “Unnecessary Use of Fluoroquinolone Antibiotics in Hospitalized Patients”
Mayo Clinic Proceedings, “The Fluoroquinolones” (“Because they may affect the development of cartilage, all fluoroquinolones are contraindicated in children, adolescents, and pregnant or breast-feeding women.”)
Clinical Infectious Diseases, “Antimicrobial Safety: Focus on Fluoroquinolones“
Drug Safety (Journal), “Drug Interactions with Quinolone Antibacterials“
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, “4 Quinolones Cause a Selective Loss of Mitochondrial DNA from Mouse L1210 Leukemia Cells“
International Journal of Oncology, “Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC“
Antimicrobial Agents and Chemotherapy, “Ciprofloxacin, a Quinolone Carboxylic Acid Compound Active Against Aerobic and Anaerobic Bacteria“
Antimicrobial Agents and Chemotherapy, “Protein Binding: Do We Ever Learn?“
Post Marketing Surveillance, “NSAIDs Quinolones and Convulsions: An Epidemiologic Approach“
The Annals of Pharmacotherapy, “Neurologic adverse effects during concomitant treatment with ciprofloxacin, NSAIDS, and chloroquine: possible drug interaction.”
Canadian Family Physician, “Case report: severe neurologic reaction to ciprofloxacin.“
IOSR Journal of Pharmacy and Biological Sciences, “Ciprofloxacin induced hormonal changes in the thyroid gland of rats and Anti-oxidant vitamin A, C and E as rescue agents“
The Annals of Pharmacotherapy, “Peripheral Neuropathy Associated with Fluoroquinolones“
Neurology, “Oral fluoroquinolone use and risk of peripheral neuropathy“
The Journal of Family Practice, “The Perils of Prescribing Fluoroquinolones“
The European Respiratory Journal, “Ciprofloxacin-induced Acute Interstitial Pneumonitis“
African Journal of Pharmacy and Pharmacology, “Effect of ciprofloxacin and levofloxacin on some
oxidative stress parameters in brain regions of male albino rats“
JAMA Ophthalmology, “Acute Psychosis Following the Use of Topical Ciprofloxacin“
Urology, “Ciprofloxacin-induced acute psychosis“
Indian Journal of Psychiatry, “Levofloxacin-induced acute psychosis“
The American Journal of Medicine, “Acute psychoses associated with the use of ciprofloxacin and trimethoprim-sulfamethoxazole“
Journal of Clinical Diagnostic Research, “Ofloxacin Induced Hypomania“
Journal of Psychopharmacology, “Antimicrobial-induced mania (antibiomania): a review of spontaneous reports.“
Connecticut Medicine, “A Possible Case of Levofloxacin Associated Amnesia, Depression, and Paresthesia“
Indian Journal of Psychiatry, “Levofloxacin Induced Acute Psychosis“
Indian Journal of Pharmacology, “Ofloxacin-induced hallucinations“
Neurological Sciences, “Levofloxacin-induced delirium“
Drug Safety, “Quinolones: review of psychiatric and neurological adverse reactions.“
General Hospital Psychiatry, “Levofloxacin-induced delirium with psychotic features.“
British Journal of Clinical Pharmacology, “Neurotoxic effects associated with antibiotic use: management considerations“
Annals of Pharmacotherapy, “Association of a Tourette-like syndrome with ofloxacin.“
Journal of Rheumatology, “Achilles Tendinopathy After Treatment With Ophthalmic Moxifloxacin“
Journal of Medical Microbiology, “Comparison of the Effects of Subinhibitory Concentrations of Ciprofloxacin and Colistin on the Morphology of Cardiolipin Domains in Escherichia Coli Membranes“
Biophysical Journal, “Characterization of the Interactions between Fluoroquinolone Antibiotics and Lipids: a Multitechnique Approach“
Brain Research, “Effects of the quinoline derivatives quinine, quinidine, and chloroquine on neuromuscular transmission.”
Clinics and Practice, “Fluoroquinolone Toxicity Symptoms in a Patient Presenting with Back Pain“
Biomed Central: Journal of Medical Case Reports, “Death Following Bilateral Complete Achilles Tendon Rupture in a Patient on Fluoroquinolone Therapy: A Case Report“
Indo American Journal of Pharmaceutical Research, “CIPROFLOXACIN INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS“
Journal of the American Dental Association, “Drug interactions in dentistry: the importance of knowing your CYPs.“
Pediatric Infectious Disease Journal, “CIPROFLOXACIN IN NEONATES AND ITS POSSIBLE ADVERSE EFFECT ON THE TEETH.“
Clinical Pharmacology & Therapeutics, “Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2“
Drug Metabolism and Disposition, “Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.“
Journal of Pharmacology and Pharmacotherapeutics, “Ciprofloxacin-induced erythema multiforme“
Journal of Antimicrobial Chemotherapy, “Antimicrobial effect of diallyl sulphide on Campylobacter jejuni biofilms” GARLIC is more effective against resistant biofilms than Ciprofloxacin.
International Journal of Tissue Reactions, “Effect of levofloxacin and ciprofloxacin injection on permeability of the tail vein in mice and skin microvasculature in rats.“
Journal of Pharmacy and Pharmacology, “Characterization of Histamine Release Induced by Fluoroquinolone Antibacterial Agents In-vivo and In-vitro“
Archives of Toxicology, “Differential response of mast cells separated from various organs and basophils of dogs to the fluoroquinolone antimicrobial levofloxacin“
Current Pharmaceutical Design, “Hypersensitivity Reactions to Quinolones“
Naunyn-Schmiedeberg’s Archives of Pharmacology, “How do basic secretagogues activate mast cells?“
Nature, “Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions“
Clinical and Experimental Allergy, “T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity“
Current Pharmaceutical Design, “Editorial [Hot Topic: An Update on the Diagnosis of Allergic and Non-Allergic Drug Hypersensitivity (Executive Editors: M.T. Ventura and A. Romano) ]“
New Trends in Allergy III, “Adverse Reactions to Quinolones“
Current Pharmaceutical Design, “Type II Topoisomerases as Targets for Quinolone Antibacterials Turning Dr. Jekyll into Mr. Hyde.“
Human & Experimental Toxicology, “Structural and functional changes by Ciprofloxacin of rat submandibular gland.“
Clinical Infectious Disease, “Clinical-trial design and selected drug safety issues for community acquired pneumonia“
Drug Metabolism and Disposition, “Quantitative Brain Microdialysis Study on the Mechanism of Quinolones Distribution in the Central Nervous System“
Antimicrobial Agents and Chemotherapy, “Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits.”
BMJ Open, “Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study“
Yes, I know that wikipedia isn’t the most credible source, but these articles have good information and citations and they’re easy to read:
Fluoroquinolone
Levofloxacin
Ciprofloxacin
Avelox
Other Research
Dropbox file of Fluoroquinolone Research
Data
Adverse Events
Cipro
Levaquin
Avelox
Support
Quinolone Vigilance Foundation
Fluoroquinolone Victims Advocacy Network
Forum for German speakers – http://fluorchinolone-forum.de/
The Fluoroquinolone Toxicity Group on Facebook – https://www.facebook.com/groups/floxies/
Subreddit for floxies – https://www.reddit.com/r/floxies/
Blogs
Cipro Poisoning: Have You Been Floxed?
Johnson & Johnson Levaquin Reaction Pain Art
Quick Health Notes, “Fluoroquinolones Can Cause Fibromyalgia“
http://www.ciprovictim.blogspot.com/
Beyond the Mirror: The Scary Monster has Appeared
FLUOROKINOLONI ANTIBIOOTTIEN PITKÄAIKAISET HAITTAVAIKUTUKSET
Fluoroquinolone Toxicity of the Thyroid
Stories of Adverse Effects
Facebook Fluoroquinolone Wall of Pain containing various stories of pain and suffering told by victims of fluoroquinolone toxicity. Click on the photos and scroll through them for the stories.
Ask a Patient
Cipro
Levaquin
Avelox
Recovery
Mark won a bike race about 2 years post-floxing. Go Mark! You rock!!!
This Needs to Stop
Girl, 2, in brave battle against arthritis after being bedridden for months with mystery illness
AWESOME article about the failure of the FDA to protect American consumers
Law firms
Misc.
Doctors Choose the Strongest Types of Drugs when Choosing Antibiotics
A Statement of Hope by Dr. Savely Yurkovsky
This is disgusting. A fluoroquinolone that has been removed from the market because it killed people was tested extensively on Nigerian children. It killed them.
Dartmouth, “Deconstructing Molecules: Cipro“
Academia, “SYNTHESIS OF NEW LEVOFLOXACIN DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY INTRODUCTION“
Animals Being Hurt by Fluoroquinolones
Veterinary Medicine, Czech, “Quinolones: A Class of Antimicrobial Agents“
Veterinary Opthamology, “Enrofloxacin Associated Retinal Degeneration in Cats“
PLoS ONE, “Antibiotics Threaten Wildlife: Circulating Quinolone Residues and Disease in Avian Scavengers“
great page, Lisa !
Lisa, this is a great website offering both good information and encouragement. I’m still coming up to speed and wanted to read the Flox report, but the link above is dead. Can you help?
Andrew
Help
As I’m sure all of you can also understand and attest to, in my never-ending quest for answers post-floxing since about 2.5 years ago, it feels like I’ve stumbled upon tons of articles, medical journals, and research papers on anything related to our conditions caused by Fluoroquinolones. I’ve searched and still manage to miss many that Lisa and others manage to post here.
I’ve found another to share in case any of you have not seen or read it. It is a medical research paper that appears to be dated back to 2013-2014:
https://www.academia.edu/8318168/Fluoroquinolone_Genotoxicity_and_DNA-Adducts?source=swp_share
Although the paper focuses on roughly a handful of affected gene mutations and DNA adducts, the very small, fine print mentions many more being affected. A key take away for me in this article is that the type of damage our bodies undergo from being Floxed is one that is normally attributed to exposure to heavy metals/environmental toxins, nuclear radiation/exposure, and inherited gene mutations. The author of this paper continues to state that the only commonality between the research participants was the FQ’s. Just as he states, instead of liking a Floxie’s experience to a typical “adverse reaction”, our bodies are responding to being poisoned from a toxic substance.
One of the effected DNA adducts also stands out for me in the provided list: CYP
I’ve understood that additional exposure to fluoride and other related chemicals (and ones that can effect post-floxing conditions such as ones causing issues with the thyroid) seemed to make my conditions either persist or increase, but didn’t realize it was also related to this DNA adduct. For any of you who have not yet tried to eliminate or reduce your exposure to chemicals in your everyday environment, I’ve found referencing resources on http://www.ewg.org (Environmental Working Group) to be helpful in that endeavor. The list of cleaning and body products tends to be my most visited and has helped me to reduce additional exposures to myself and my family that I was unaware of previously.
I hope this information and resource may offer some additional help and healing.
German (and French) speaking Floxie Site: https://www.fluorchinolone.info
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I appreciate you sharing this blog post. Thanks Again. Cool.
very informative articles or reviews at this time.
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Great information shared.. really enjoyed reading this post thank you author for sharing this post .. appreciated
Lisa, This is a fantastic website that provides helpful advice and inspiration. I wanted to read the Flox report because I’m still getting up to speed, but the link is broken. Can you assist?
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Lisa, This is a wonderful website that offers insightful guidance and motivation. As I’m still getting up to speed, I wanted to read the Flox report, but the link is broken. Can you help me? I’ve listed the top coupon websites for you to use, Andrew. Next, go check out the Thomas Cook Coupon Code.
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I was told there is a list of all fluoroquinolone meds here, but I’ve looked around a lot and I can’t find it.
I was floxed 5 years ago. Shortly after putting every recommendation from Lisa, into my daily routine= healing! I found a local doctor from a resource link from the old Floxie hope page. I cannot find that link that had doctors broken out by state. I now have a friend in need, and would like to seek a doctor like the one I found that helped me in my healing journey. Does anyone know where that page / link might be stored? Thank you in advance for your assistance.
make the resource tab easier to find, like it used to be. IT should have it’s own heading on the home page