Mark W’s Recovery Story – Cipro Toxicity

Cipro Side Effects Recovery Story

*The following is an individual’s story of surviving fluoroquinolone toxicity. It is not medical advice. Please see the disclaimer at the bottom of the story. Thank you, and please be cautious with all treatments. 

Mark W 06/29/2012

I am a 35 year old math professor. I took Cipro 500mg twice per day for a UTI over 4 days from May 11th to May 15th 2010. After 8th pill I had a horrible reaction. Usual symptoms, cramping, burning, muscle twitching, brain fog, nightmares, felt like I was being dried out and like my head was being twisted in a vice. Could barely walk for months afterwards. I felt utterly destroyed and thought I would never recover. I also thought my career as a research mathematician was over and that I would end up permanently disabled and unable to cope with any sort of stress or responsibility. I read all sorts of horrifying stories online about cipro damage which utterly smashed my morale. One promise I did make was that if I ever recovered, I would post it somewhere to give hope to those who may feel now as I felt then. My heart goes out to all of you. I am now happy to say that I am running, biking, lifting weights and playing football (“soccer” to you Americans) regularly. Getting better has been a long and difficult road involving physical therapy, acupuncture and copious amounts of magnesium (both oral and topical) and vitamins B, D and E. Whether or not some or all of these therapies were placeboes is impossible to say. They certainly felt like they helped. All I know is that, bar some minor aches and pains, I am much much better. NEVER EVER GIVE UP.

** The story above is truthful, accurate and told to the best of the ability of the writer. It is not intended as medical advice. No person who submits his or her story, nor the people associated with Floxie Hope, diagnoses or treats any illness. The story above should not be substituted for professionally provided medical advice. Please consult your doctor before trying anything that has been mentioned in this story, or in any other story on this site. Please also note that people have varying responses to the treatments mentioned in each story. What helps one person may not help, and may even hurt, another person. It is important that you understand that supplements, IVs, essential oils, and all other treatments, effect people differently depending on the millions of variables that make each of us unique. Please use appropriate caution and prudence, and get professional medical advice.

43 thoughts on “Mark W’s Recovery Story – Cipro Toxicity

  1. Hurley Rez September 17, 2013 at 8:05 am Reply

    Excellent! Thank you for sharing Mark 🙂 May you have a happy body for the rest of your days 🙂 I am still fighting this, did not know what is was until 6 months ago, but mine stated almost 3 years ago! I appreciate your posting such fabulous news.

  2. Teresa October 29, 2013 at 10:16 am Reply

    Glad to here from you Mark. I knew on pill 4 of levaquin I had been poisoned. I’ve been swallowing lots of vitamins and looking forward to days with out pain too!

  3. Brian December 8, 2013 at 7:19 am Reply

    Mark, did you experience muscle loss which you then reversed ? I am 8 months out , and really lean ,due to a job that is very strenuous . But I wasn’t lean prior to flox , and I am talking about loss of muscle mass . About 30 lbs worth . Just curious as to if your journey is similar to mine . Thanks. 🙂

    • Kristina March 2, 2019 at 5:28 pm Reply

      I have muscle loss too! Would love to hear if others have recovered muscle mass.

      • Juliet December 15, 2020 at 2:29 pm Reply

        Kristina-how are your muscles? Have you been able to regain any of them?

  4. Jane December 19, 2013 at 3:16 pm Reply

    How long did it take you to recover? I’m struggling after 8 months post floxie.

  5. cj February 14, 2014 at 2:50 am Reply

    I,m not well.6 years out.i think my tendon issues are permanent and more pop up every month.

  6. Charles Tooraen April 1, 2014 at 1:21 pm Reply

    Brian, I lost about 30lbs in the first two months. Now going on month 4 I have gained about 10 lbs back. But my digestion has gotten better, so I assume I am absorbing more nutrients. It’s a long process. I am currently not taking anything since I seem to have reactions to everything I take.

  7. Charles Tooraen April 1, 2014 at 6:06 pm Reply

    Does anyone know how Mark is doing now, 4 years out?

    • Lisa Bloomquist April 1, 2014 at 7:05 pm Reply

      When I chatted with Mark in September, 2013 he was doing well. Life had returned to normal.

  8. Charles Tooraen April 1, 2014 at 7:11 pm Reply

    WooHoo!! Now If I could only fast forward and still keep my job…. 🙂

  9. ifi April 2, 2014 at 6:54 am Reply

    For men with pains,check testosterone levels.

    • Mark May 31, 2014 at 3:23 pm Reply

      Please go into more detail about the testosterone.

      I got 2x500mg Cipro for 10 days and pain started 2 days after the last pill.
      Not it has been 2 weeks since the last pill and I still got tendon pain all over anxiety and ringing in my ear
      Why I’m asking: I’m on testosterone replacement therapy and should have gotten my next shot 3 weeks ago but I’m pushing it further because I’m scared that it could worsen my symptoms.

      Can you please shed some light?


      • Brian May 31, 2014 at 7:27 pm Reply

        Mark, I’m also on TRT and my shots didn’t worsen my flox symptoms. Stopping your TRT suddenly will probably make you feel worse both mentally and physically. That would be true even for non-floxies.


      • Mark June 1, 2014 at 1:19 am Reply

        Brian, I can’t respond to you directly don’t know why…

        How did your muscle react to the needle?

        Did your symptoms get better after each shot?


        • Azz July 10, 2020 at 2:22 am

          Hi Mark, it’s been a few years but I’m in the same boat as you. Did you end up taking trt again? And did you get a reaction?

      • Brian June 1, 2014 at 10:10 am Reply


        My muscles reacted the same to needle as they did pre-flox. The shots didn’t seem to affect my flox symptoms one way or the other.


      • Mark June 1, 2014 at 10:24 am Reply

        Could you please go into a little more detail as to:
        -what your symptoms at the time were

        -how much/frequently you got testosterone and in which form

        -how high your testosterone level was during treatment

        -how long it took you to heal from the cipro

        -if you kept your muscle and weight

        -if you got depression and axiety

        -what else you did to help your situation?

        I’m asking a lot but I just am so happy to have found someone that took Cipro and is on TRT to talk about.


  10. Jocelyn May 3, 2014 at 5:51 am Reply

    Mark said that he had the muscle twitching and this is one of my worst symptoms. Is there any way to ask Mark when the twitching stopped or if anything helped the twitching?? Thank you! (I am about 4 months out and twitching has slowed down and is mainly in my legs)

  11. Brian May 3, 2014 at 11:35 am Reply

    I am glad to hear that you are still metabolizing nutrients. I too have lost a good 30 plus muscle pounds, and was able to put 20 back on as gut weight. Still hoping someone can find a way to regain muscle. Power to you Mark.

  12. Brian May 3, 2014 at 11:40 am Reply

    Magnesium helped me, twitching stopped around the 3 month mark. It is losing muscle…the magnesium is used to send signals to relax the muscle, minimizing the pain and offsetting the calcium signaling (that tightens muscle) . FQs deplete magnesium. Add some to your diet if you can tolerate it. I am one year out.

    • Mark June 26, 2014 at 2:53 am Reply


      How are you now?
      Did your situation improve?


  13. Jocelyn May 3, 2014 at 4:55 pm Reply

    Thx. I have been on a lot of magnesium for about three months (4 months since taking levaquin). Twitching has slowed down but still quite constant in calves and feet. What kind of magnesium did you take and how much? I can almost tolerate the pain more than twitching. At one year are you seeing the light at end of tunnel?? This does get better right?!?

  14. brian June 2, 2014 at 8:50 am Reply

    Hi Mark,

    My symptoms were less severe than many floxies, but I’ll try to answer your questions.

    -what your symptoms at the time were
    Some joint, muscle, tendon pain.

    -how much/frequently you got testosterone and in which form
    Tesosterone Cypionate 200mg injected every other week.

    -how high your testosterone level was during treatment
    Sorry, don’t remember.

    -how long it took you to heal from the cipro
    Well, I’m not really completely healed yet. Still have tinnitus and insomnia and occasional (mild) musle/joint pain.

    -if you kept your muscle and weight
    I lost some muscle and weight, but not too much.

    -if you got depression and axiety

    -what else you did to help your situation?
    Magnesium. I haven’t tried many other supplements.

    Hope this helps.


    • Mark June 2, 2014 at 9:07 am Reply


      Yes thank you.
      I got the shot today and I felt it immediately.

      During the shot my muscle twitched a little which was stressful.
      My tendons are a little stiffer now and hurt slightly more, it kinda felt like the bodywater came back into my body, can’t tell if that’s a bad or a good thing.

      Anyways it’s good to hear that you didn’t get bad symptoms, maybe it’s related.

      Can you tell me how long it has been since your last Cipro tablet and for how long/how much you got it?


  15. brian June 2, 2014 at 11:27 am Reply

    Hi Mark,

    It’s been a little over a year and a half since the Cipro. I was on 2 courses. The first was a 7-day course of 250mg/day. The second was 1.5 weeks of 500mg twice a day. It was supposed to be a 6-week course, but I stopped it when my symptoms flared up.


    • Mark June 3, 2014 at 4:18 am Reply

      Sorry to ask so many questions.

      How old are you?

      Did you have symptoms after the first treatment?

      What did you do to recover?


    • Mark June 3, 2014 at 4:19 am Reply

      Oh and when did the symptoms peak?

  16. brian June 3, 2014 at 5:55 am Reply

    Hi Mark,

    I’m 53. It was about 1 week into the second course of Cipro before I started having symptoms. I haven’t completely recovered, but as I said, magnesium glycinate helped. I didn’t take any other supplements. I take 10mg amitryptilene at night which helps my sleep a little, but that’s about it. I tried accupuncture, but it didn’t do much for me. Aside from that, I’m just hoping this goes away with time.


    • Mark June 3, 2014 at 7:56 am Reply

      And after the symptoms started after the first week, did it continue to get better slowly or became worse gradually before becoming better?

  17. brian June 4, 2014 at 8:54 am Reply

    My symptoms worsened a bit before they became better.


    • Mark June 4, 2014 at 2:06 pm Reply

      Man I know that I’m getting on your nerves, sorry for that, but how long until they started to get better?

  18. brian June 4, 2014 at 5:08 pm Reply

    I’m sorry Mark, I really don’t remember. -brian

  19. Britain June 6, 2014 at 4:44 pm Reply

    Jocelyn, it’s been a change of lifestyle for me…..mag glycinate absorbs better. So does citrate….oxide is junk for our needs. I have made permanent changes to diet and activity to cease loss of muscle and enjoy my body longer. That is my perception of matters as I am experiencing them. Be well. (:

    • Mark June 7, 2014 at 4:06 am Reply

      Hi Britain,

      How long has it been for you?
      Are you healed yet?

      What made symptoms worse and what made them better?


  20. Billy Sosa April 23, 2015 at 10:28 pm Reply

    Mark, what was the brand of topical Magnesium you used after being floxed? I was floxed on June 29th, 2014. It’ s been 9 months since being floxed. My knees hurt and are super stiff when I run still. I take Magnesium Citrate and have done acupuncture. I have not tried a topical magnesium yet.

  21. Linda February 1, 2016 at 10:25 am Reply

    So good to hear. Thank you for posting this.

  22. vittle December 9, 2016 at 3:10 pm Reply

    Glad to hear you recovered Mark. It’s been 9 months since I took a 7 day course of cipro (500mg x2 a day) and I still can’t work more that 50 yards without my achilles feeling like they are going to snap. I also lost 30 lbs of muscle. Just skin and bones now. How were you doing in terms of walking/running around the 9th month?

  23. Rob Ferguson BS BioCh April 17, 2017 at 7:44 pm Reply

    My symptoms decreased substantially when I began to double dose PQQ and CoQ10. I believe cipro mimics PQQ in the body and poisons the sites it catalyzes. Cipro is essentially PQQ with a Fluorine group and a few extra carbons.

    • Amy September 13, 2017 at 8:38 pm Reply

      I just ordered MitoQ. I hope it works well at healing.

    • Azz November 21, 2017 at 8:20 pm Reply

      Hi a bit off topic but it seems you have some knowledge of things, I was on testosterone therapy (testosterone enanthate) prior to being floxed and have been terrified to take it again incase it made things worse. In your opinion would it be safe to take again? As it contains carboxylic acid heptanoic.


    • Anna Paula Zanardi Ursini May 6, 2020 at 1:44 pm Reply

      Como assim?
      O pqq melhora ou piora os sintomas?

  24. Dan Jervis March 2, 2019 at 4:30 pm Reply

    Dear Mark, I am Dan Jervis, the last one on the long list. Would you please consider sharing your story to CBS 60 Minutes?

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