Tag Archives: depression

Floxie Hope Podcast Episode 18 – Clara

I had the pleasure of interviewing Clara for episode 18 of The Floxie Hope Podcast.

Please check it out!

http://www.floxiehopepodcast.com/episode-018-clara/

https://itunes.apple.com/us/podcast/floxie-hope-podcast/id945226010

You can download all episodes of The Floxie Hope Podcast through any podcatcher app that connects to iTunes.

In this episode of The Floxie Hope Podcast Clara goes over her fluoroquinolone toxicity symptoms, as well as some things that have helped her. She gives wonderful insight and advice!

After taking Cipro, Clara’s toxicity symptoms included:

  • Nausea
  • Loss of appetite
  • Insomnia
  • Loose teeth
  • Bleeding gums
  • Getting sick easily / suppressed immune system
  • Anxiety
  • Depression
  • Fatigue
  • Brain fog
  • And more

Clara has improved greatly with the assistance of a naturopathic doctor who focuses on balancing her hormones. She has also benefitted from an anti-candida diet, and several supplements. Please listen to the podcast for more information about her journey.

Thank you so much for being on the podcast, Clara! Your journey is inspirational and valuable!

 

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Serious Psychiatric Reactions from Fluoroquinolones

Heather McCarthy News Story

Please read and share post, “Psychiatric Adverse Reactions to Pharmaceuticals Ignored” that was published on Hormones Matter. It highlights the tragic story of Shea McCarthy, a young man who lost his life after suffering from a severe psychiatric adverse reaction to Levaquin.

The severe psychiatric adverse reactions to fluoroquinolones need to be recognized and acknowledged. No one is choosing to have a severe psychiatric adverse reaction to a drug, yet people with psychiatric adverse reactions are often ignored and disregarded. As you can see from Shea’s tragic story, not listening to people who have psychiatric adverse reactions to drugs can have tragic consequences.

Here is the video of the news story, “CALL 6: Mother blames antibiotic for son’s death – Purdue University student took Levaquin:”

There are several possible mechanisms through which fluoroquinolones can cause anxiety, depression, insomnia, psychosis, and other severe psychiatric adverse-effects. Oxidative stress may be the mechanism through which fluoroquinolones cause severe psychiatric problems, as I described in “Can Antibiotics Induce Psychiatric Reactions?” Maybe gut microbiome destruction by fluoroquinolones leads to the psychiatric adverse effects. The Psychology Today article, “The Gut-Brain Connection, Mental Illness, and Disease” goes over evidence that our gut microbiome is intricately linked to our mental health. Obviously, fluoroquinolones are powerful antibiotics that destroy the gut microbiome. Another possibility, one that I have not previously explored, is that fluoroquinolones cause severe psychiatric reactions because they have a piperazine attachment to the quinolone core. In the picture below, the quinolone core is zone 4 and the piperazine attachment is zone 3.

Cipro Molecular Structure

Ciprofloxacin is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid.

Piperazine blocks GABA activity. GABA is gamma-Aminobutyric acid, “the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays the principal role in reducing neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone.” (wiki) When GABA is blocked, people feel edgy, agitated, excited (not in a good way), anxious, and can suffer from insomnia, muscle spasms, seizures, and more.

Piperazine is often used “for making fake ecstasy because of the similarity in taste, and at certain doses, a user may experience favorable side effects and feel ‘high.’” (source) It is also often mixed with MDMA in ecstasy.

Additionally, it is noted in “Acetylcholine (ACh) – Related Damage” on http://fluoroquinolonethyroid.com/ that:

“Piperazines (anti-parasiticals which kill parasites by paralyzing them) have neuromuscular effects which are thought to be caused by blocking acetylcholine at the myoneural junction. (Plenty of pets have been poisoned with over the counter piperazine toxicity from wormers – so no, it’s not just helminths they affect). Among the numerous properties of Piperazine derivatives, they are not only muscarinic antagonists, but also are the basis for recreational drugs with euphoria and stimulant properties, such as amphetamines, BZP, MDMA [rather, ecstasy, as noted above], and TFMPP, along with all the negative side effects of these drugs (no wonder I was hallucinating during my acute reaction). So now we have a toxic neuromuscular agent with amphetamine/ecstasy-like effects (piperazine), along with a toxic iodine displacer (fluorine), attached to a chemotherapeutic agent with an intracellular, intranuclear, and intra-mitochondrial genotoxic mechanism of action (quinolone) – a synthetic, fluoridated, neurotoxic, genotoxic chemotherapeutic poison masquerading as an antibiotic and being given en masse to the human and animal population.”

Fluoroquinolones “are known to non-competitively inhibit the activity of the neurotransmitter, GABA, thus decreasing the activation threshold needed for that neuron to generate an impulse.” (source, source, source) Fluoroquinolones have also been shown to have similar effects on GABA neurotransmitters as benzodiazepine withdrawal (source).

The inhibition of GABA by the piperazine part of fluoroquinolones is a plausible, even likely, mechanism for the many horrible psychiatric effects that people suffer from after taking fluoroquinolones.

In a survey of 94 people who experienced adverse reactions to Levaquin/levofloxacin, a fluoroquinolone antibiotic, 72% reported experiencing anxiety, 62% reported depression, 48% reported insomnia, 37% reported panic attacks, 33% reported brain fog and/or cognitive impairment, 29% reported depersonalization and/or derealization, 24% reported thoughts of suicide and 22% reported psychosis. (source, source)

More than 20 million prescriptions for fluoroquinolones are given out in the U.S. each year. If even only 1% of the people who take fluoroquinolones experience a psychiatric adverse-reaction, that’s still a lot of people whose minds aren’t their own, who are suffering from depression, anxiety, insomnia and worse, because of an antibiotic that is made with a chemical that has amphetamine/ecstasy-like effects.

These effects can have tragic consequences, as can be seen in the video and article mentioned above about Shea McCarthy.

Psychiatric adverse effects of prescription drugs are serious, and they should be taken seriously. They are not a choice. No one would choose to feel psychotic, or even anxious.

There are many plausible mechanisms through which fluoroquinolones can cause psychiatric problems. Perhaps it is time that the psychiatric effects of fluoroquinolones become more widely recognized.

 

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The Hardest Topic – Suicide

People who are in pain, and depressed, and desperate for help, and who have had everything that they cherish taken away from them–their health, their mental health, their job, their family, their money, their stability, and more–often reach out to me. I am happy to do what I can to help. I tend to be at a loss for words when people are suicidal though. I don’t know the right thing to say or do when people are considering ending their life. I can tell them that I’m so sorry for all the pain and anguish, and I am–I truly feel sorrow. I can tell them that it will change and it will pass–but those things sound trite when a person is in constant pain and they’re wondering if the pain will ever end, or when a person is feeling like their life is already over, or when a loved one leaves them because they don’t understand.

I tell people to reach out to suicide prevention counseling services. I think they should. If you are suicidal as you read this, please, please reach out to a suicide prevention counseling service. Here are a couple:

 

National Suicide Prevention Lifeline

http://www.suicidepreventionlifeline.org/

1-800-273-8255

 

IM Alive

http://hopeline.com/

1.800.SUICIDE (1-800-784-2433)

 

The people who answer those phone lines are trained, and they know what to say to help you to get through to tomorrow. Please reach out to them if you need to.

I’m not particularly good at helping people who are suicidal because I was never “there.” There were moments in my fluoroquinolone toxicity journey when I thought that life as I knew it was over, but I never considered ending my life.

There are other floxies who have gone through such pain and anguish (physical, mental, emotional and spiritual) that they did consider ending their life. There are floxies who have gotten through periods of being suicidal who can tell you from first-hand experience that it passes and gets better. There are even people who were severely floxed, and suicidal, who have recovered. They truly understand how horrible it can be, and they also know that it gets better.

I think that it would be helpful to floxies who are currently scared and suicidal to talk to people who have been through what they’re going through. If you’re a person who has gone through the worst of fluoroquinolone toxicity, who is willing and able to talk to other floxies who are in this horrible position, please let me know through the Contact link above, and I will put you in touch with people who can use your empathy and guidance when they reach out through this site.

If we can work together to help people who are suicidal because of the effects of fluoroquinolones, maybe we can help to save some lives.

Please, friends, use the resources that are available if you are feeling suicidal. The hotlines mentioned above are open 24/7.

And please know that there are people who understand, who have been “there,” who have made it through to a better place, and who are thankful that they lived to see the better place. Hang in there, keep going, it gets better, one step at a time, you can do this.

 

 

A few floxies have lost their lives recently, and my heart truly aches for their loved ones. To everyone who is grieving for the loss of a loved one, I am truly sorry for your loss. You are in my thoughts. My deep-felt condolences to you and your loved ones.

 

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The Floxie Hope Podcast Episode 12 – Elise

Elise Floxie Hope Podcast

 

I had the pleasure of interviewing Elise for Episode 12 of The Floxie Hope Podcast.

Elise shares a lot of valuable information in her podcast.  She goes over her long journey of fluoroquinolone toxicity, and things that she has done to heal, in the podcast.

You can listen to the podcast through these links –

http://www.floxiehopepodcast.com/episode-012-elise/

https://itunes.apple.com/us/podcast/floxie-hope-podcast/id945226010

Elise has generously offered to help anyone who wants to reach out to her –

Elise’s facebook info: https://www.facebook.com/elise.child.5

Email: elisedchild@gmail.com

In the podcast, Elise mentions that her naturopathic doctor, Dr. Cynthia Buxton, has helped her immensely.  Dr. Buxton can be found through this link – http://naturalhealthcarenw.com/?p=346

Elise was also helped by eating for her blood type.  Information about that can be found here – http://www.4yourtype.com/

The TQI diet also helped Elise – http://toquietinflammation.com/

Univera Xtra also helped Elise – https://www.newunivera.com/en-us/search?Text=xtra&Area=Products

Elise also found Cleansing/gut health options to be helpful: https://humaworm.com/, http://www.renewlife.com/herbal-cleansing/paragone.html

Liver support: Elise currently takes a tincture with milk thistle, dandelion, etc.

Elise noted, “I forgot to mention the value of amino acid therapy in my own healing, which can be extremely helpful with depression, anxiety, insomnia, getting off of antidepressants, etc. I feel it is very important to do this with one’s doctor for dosage, length of use and quality of supplements. Amino Acid Therapy Info: (some examples, lots of info out there) http://www.neurogistics.com/thescience/aminoacids.asp, http://www.antianxietyfoodsolution.com/wp/wp-content/uploads/2014/11/Anxiety-mood-emotional-eating-sugar-cravings-mood-quiz-by-Trudy-ScottV2.pdf

If you have any questions about any of these products, please contact Elise.

Thank you for listening to The Floxie Hope Podcast!  Stay hopeful, friends!

 

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Can Antibiotics Induce Psychiatric Reactions?

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Fluoroquinolones cause mitochondrial damage and oxidative stress.  Mitochondrial damage and oxidative stress have been causally linked to all sorts of psychiatric disorders, including, but not limited to bipolar disorder, depression, attention deficit hyperactivity disorder, anxiety, etc.  Fluoroquinolones are bad for your brain.  Reactive oxygen species have hugely deleterious effects on all parts of the body and mind.

 

The full post can be found here –

https://www.hormonesmatter.com/antibiotics-psychiatric-reactions/

 

Thank you, as always, for reading and sharing information about the dangers of fluoroquinolones!

 

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