Search Results for: mitochondria

Are Damaged Mitochondria Causing Autoimmune Diseases?

Fluoroquinolone toxicity looks and feels a lot like multiple autoimmune diseases including rheumatoid arthritis, lupus, MS, thyroid autoimmune diseases, and others. Some people have proposed that fluoroquinolone toxicity is its own autoimmune disease, but the auto-antibodies have not yet been identified and thus it is not treated as an independent autoimmune disease. In some people, …

Mitochondria Summit

I just had surgery (just a couple hours ago as I write this), so this post is going to be short and sparse. BUT, I wanted to let you all know that there is a summit about Mitochondria that is happening THIS WEEK (December 9-15). You can access it through clicking on the image above, …

New Study Finds that Ciprofloxacin Depletes Mitochondrial DNA

An excellent article about the effects of ciprofloxacin (a fluoroquinolone antibiotic) on mitochondrial DNA was recently published in the journal, Nucleic Acids Research. The article, Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2, by Anu Hangas, Koit Aasumets, Nina J Kekäläinen, Mika Paloheinä, Jaakko L Pohjoismäki, Joachim M Gerhold, and Steffi Goffart, gives a …

Mitochondria, Neuropathy, HIV, and Fluoroquinolones

Mitochondria and Peripheral Neuropathy – Article out of Johns Hopkins I highly recommend reading this article – Feet First? Old Mitochondria Might Be Responsible For Neuropathy In The Extremities It’s a fascinating article out of Johns Hopkins Medicine. It goes over the connection between mitochondrial damage and peripheral neuropathy. As an explanation as to how …

NSAIDs and FQs Damage Mitochondria, Increase Oxidative Stress, and Cause Cell Death

As I noted in the post, Why NSAIDs Suck for Floxies (and Probably Everyone Else Too), NSAIDs often exacerbate fluoroquinolone toxicity symptoms, and there are several mechanisms through which NSAIDs can interact with fluoroquinolones. The results of a recent article published in the Journal of Molecular and Cellular Cardiology by researchers at UC Davis, Different effects of …

The Mitochondrial Link – Fearless Parent Podcast #81

In my first episode as a host of the Fearless Parent Podcast, I interviewed Dr. Chris Meletis about mitochondria, and how mitochondrial damage relates to health and chronic illness.  Dr. Meletis is brilliant and insightful and it was an honor to have him on the show! You can learn more about the show, and download …

Study Finds that Ciprofloxacin Depletes Mitochondrial DNA

This post contains quotes from the article “Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in Ciprofloxacin-Treated Mammalian Cells” that was published in Molecular Pharmacology in 1996.  It’s a good article.  It’s an interesting and damning article.  It’s a difficult article.  It would be nice if more people read it, and I wish that its implications were …

Fluoroquinolones Damage Mitochondrial Lipids

Fluoroquinolones are Mito-Toxic Many articles about how fluoroquinolones damage mitochondria and lead to mitochondrial dysfunction have been published.  In Science Translational Medicine, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells,” it is noted that bactericidal antibiotics, including ciprofloxacin, a fluoroquinolone, “damage mammalian tissues by triggering mitochondrial release of reactive oxygen species (ROS).”  Additionally, …

Mitochondria, Neuropathy, HIV and Fluoroquinolones

I wrote the following post and put it on one of my other sites, Mito Madness. Mitochondria, Neuropathy, HIV and Fluoroquinolones Though the damage done by fluoroquinolones to mitochondria is well documented, as is the connection between mitochondrial damage and many illnesses and maladies, the knowledge of the connections is not widespread.  Hopefully, some emerging …

Dr. Robert Rountree’s Presentation about Mitochondria

I highly recommend that you watch this – http://www.viddler.com/v/703896d9?secret=27514482 It’s a video of Dr. Robert Rountree giving a presentation about mitochondria. It’s fascinating! Fluoroquinolones damage mitochondria. Here are my posts about fluoroquinolones damaging mitochondria – Fluoroquinolone Antibiotics Damage Mitochondria – FDA Does Little The Fluoroquinolone Time-Bomb – Answers in the Mitochondria Same Disease, Different Symptoms: …

Fluoroquinolone Antibiotics Damage Mitochondria – FDA Does Little

The Pharmacovigilance folks at the FDA know that fluoroquinolones are damaging mitochondria.  Yet, they look the other way.  Adding a more severe warning about peripheral neuropathy to the warning label isn’t helpful.  People should know that they are increasing their risk of every chronic disease associated with mitochondrial damage and oxidative stress when they take …

Same Disease, Different Symptoms: It’s all in the Mitochondria

Fluoroquinolone toxicity affects everyone differently. Why? Because that’s how mitochondrial dysfunction works. WHY? Because mitochondrial produced ROS influence gene expression and we all have different genes. WHAT? Yup, ROS affect gene expression. Perhaps we should be more careful with our mitochondria. After all, our genes are at stake. Same Disease, Different Symptoms:  It’s all in …

Your Mighty Mitochondria

  Fun facts – Nalidixic acid, the chemical compound that is the base of all fluoroquinolones, was discovered in 1962. Mitochondrial DNA was discovered in 1967 (by Lynn Margulis who happened to be married to Carl Sagan). So, if you are under the impression that naladixic acid was tested for its affects on mitochondrial DNA, …

Mitochondrial Dysfunction and Related Diseases

  This post, entitled “Some Doctors Don’t Believe In This Disease Yet it Predisposes Many Diseases” was published on Collective Evolution on 03/17/14. http://www.collective-evolution.com/2014/03/17/mitochondrial-diseases/ Frustratingly little is known about mitochondria and the role that they play in human illness.  I hope that this will change soon.    

The Fluoroquinolone Time-Bomb – answers in the Mitochondria

Adverse reactions to fluoroquinolones are often delayed and people can tolerate a certain number of fluoroquinolones before they experience an adverse reaction. Delayed reactions and tolerance thresholds are perplexing mysteries until you take a look at mitochondrial dysfunction. Both delayed reactions and tolerance thresholds are actually typical for disease states that are caused by mitochondrial dysfunction. …

Article Breakdown – “Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria”

Do you have a headache?  Do you want one?  If so, read this article – “Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria” written by Dean P. Jones, John J. Lemasters, Derick Han, Urs A. Boelsterli, Neil Kaplowitz If you want a headache that lasts a while, read these articles that give …

Fluoroquinolone Caused Mitochondrial Damage and Oxidative Stress – What are the Consequences for Floxies?

I’m working on a couple of posts/articles/essays right now about how all sorts of chronic diseases, from diabetes to alzheimer’s to autism, are caused by mitochondrial damage and oxidative stress.  I’m pointing out that pharmaceuticals cause mitochondrial damage and oxidative stress.  Of course, I’m focusing on my least-favorite pharmaceuticals, fluoroquinolones, and am trying to make …

Article Breakdown – “Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression: Mechanism of Ciprofloxacin-Mediated Immunosuppression”

I’ve read this article 14 times. I think that I understand it. It’s not an easy article to read. Actually, it’s a beast. I’m going to go over what I think are the interesting points of the article in this post. I’m also going to go over something that I think the researchers got wrong, …

Floxed in the time of COVID-19

The world has shifted. Most of us started the year as if 2020 was going to be a continuation of the norm of 2019, but the world shook, and all assumptions are now out the door. We are dealing with a global pandemic. COVID-19, the novel coronavirus, has reached every state in the U.S. and …

Fluoroquinolone Toxicity Studies

A couple fluoroquinolone toxicity studies are being conducted. Dr. Charles Bennett, a Professor at the University of South Carolina College of Pharmacy, is conducting a study of genes related to fluoroquinolone toxicity. Dr. Bennett is seeking “floxed” participants in the study. In the “Floxed Friday” newsletter sent out by Michelle Polacinski – Floxie, Director, and …

Erin’s Story of Chronic Illness, Fluoroquinolone Toxicity, and Healing

Hi, my name is Erin and I’m almost in my 7th year post-Cipro. Like many of you, my experience has been long, confusing, hard to pull apart, and lacking certainty. I’ll share my story anyway in case it gives you hope, perseverance, permission to grieve, or a clue that may be helpful to you! In …

Hazel’s Recovery Story: Visual System Damage from Avelox

Welcome to my Avelox Floxing story. Firstly, 1000 thanks to Lisa and all the contributors to Floxie Hope: your kindness and advice has eased me through the worst of the FQ trauma. I’m still finding my way back to full recovery, if that’s possible, but I’m sending this out now because I’d like to hear …

Dr. Bennett identifies what the government should be doing — but isn’t — to guard against unsafe prescription drugs

Dr. Charles Bennett has been an advocate for addressing fluoroquinolone safety concerns for many years. He has has filed multiple petitions with the FDA to get them to change the warning labels for fluoroquinolones–one of the petitions is to get the FDA to add Psychiatric Adverse Events to the Levaquin/levofloxacin warning label, another is to …

Why All Recovered Floxies Are Only 99% Better

Every Friday Michelle Polacinski, a Floxie as well as the Director and Producer of ‘Floxed,’ sends out a newsletter to those who have subscribed to the ‘Floxed’ newsletter. The Floxed Friday updates are always interesting and thoughtful, and Michelle has given me permission to share them here.    If you would like to receive the …

Study Finds That Antibiotics Make Viral Infections More Deadly

New research out of the Francis Crick Institute in London found that antibiotics can worsen viral infections and increase mortality when viral exposure occurs. The research findings published in Cell Reports, “Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection” noted that: “Our study argues that caution should be exercised when …

Floxed Friday – Levofloxacin in the Hospital

Every Friday Michelle Polacinski, a Floxie as well as the Director and Producer of ‘Floxed,’ sends out a newsletter to those who have subscribed to the ‘Floxed’ newsletter. The Floxed Friday updates are always interesting and thoughtful, and Michelle has given me permission to share them here.    If you would like to receive the …

The A to Z of Fluoroquinolone Toxicity Syndrome

The following was written by Kim Jansen. You can read Kim’s story of fluoroquinolone toxicity HERE.  If you are interested in writing a guest-post for floxiehope.com, please let me know. Here is a post with more information about writing for floxiehope. Here is a version of this post that is easier to read and print. …

Ciprofloxacin Depletes Exosomal DNA

The study, “Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA” published in Nature, found that, “ciprofloxacin induced the release of both DNA (mitochondrial and chromosomal sequences) and DNA-binding proteins on the exofacial surfaces of small extracellular vesicles referred to in this paper as exosomes.” And, “Our results reveal for the first time that …

Dan’s Story – War with Chronic Pain

Note from Lisa – This is an unusual story for Floxie Hope. Most of the stories on this site are recovery stories. The people who shared them have been through fluoroquinolone toxicity, and now consider themselves to be recovered. Many people have had ups and downs, but at the time that they write their story …

Al’s Recovery Story – Cipro Toxicity along with Lyme Disease

I was put on a dose on Cipro to treat an infection called Bartonella, which is a coinfection of Lyme Disease. I lasted about a day (2 doses) before my ankles started aching. 3 days in I could barely stand. I called the Doctor and he told me to stop the drug and replace it …

Ross’s Story of Fluoroquinolone Toxicity

My Fluoroquinolone Story – My long term health issues make me a little different to the rest of you. In the late 1980’s I developed Acromegaly. Acromegaly is an excess of Growth Hormone due to an enlarged Pituitary Gland up under the brain next to the Hypothalamus. Subsequent to this I have had Trans-sphenoidal surgery …

Are Fluoroquinolones Causing Connective Tissue Disorders that are Leading to ME/CFS?

The symptoms of fluoroquinolone toxicity often mimic those of ME/CFS (Myalgic encephalomyelitis/chronic fatigue syndrome). Many people suffering from fluoroquinolone toxicity experience debilitating fatigue, and some are bed-bound and permanently disabled from this symptom, along with all the others that come along with fluoroquinolone toxicity. Both fluoroquinolone toxicity and ME/CFS are multi-symptom, chronic syndromes that are …

The Loss of a Loved Community Member

The “floxie” community lost a wonderful person last week. His name is Marc Thavenot, and Levaquin killed him. Marc struggled with fluoroquinolone toxicity for three years. He fought for his life every day of those three years. However, in November 2018 he lost his battle. Officially, his cause of death was suicide. But the truth …

Fluoroquinolone Toxicity Awareness Friday

Today, Friday November 9th 2018, is the first Fluoroquinolone Toxicity Awareness Friday. Please join me, and other fluoroquinolone toxicity awareness advocates, in spreading the news far and wide about the dangers of fluoroquinolones, and the devastation and destruction that fluoroquinolones have brought to too many lives. Mark A Girard, fellow fluoroquinolone victim and advocate, posted …

Letter to the EMA

Following is a letter that I (Lisa Bloomquist) wrote to the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP). The CHMP will be reviewing fluoroquinolones starting on November 12, 2018, and they will make recommendations for use, marketing, and restriction of fluoroquinolones. Please consider sending a similar letter to them before 11/12/18. …

EMA Decision on Fluoroquinolones – Next Steps

The EMA (European Medicines Agency) review of fluoroquinolones is ongoing, and your input is requested/needed. On June 13, 2018, the EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) heard testimony from Europeans who suffered from fluoroquinolone toxicity, and on May 10, 2018, the PRAC issued their recommendations. (You can read and view the patient/victim testimonials HERE, HERE, …

Salim’s Story – Ofloxacin Poisoning and Recovery

My name is Salim, I’m french, 45 years old, married and we have a son. One year ago, in September 2017, I got a gallbladder infection and ER doctors gave me a 14 days ofloxacin course. This was not the first time I had to take a fluoroquinolone, two years ago after a suspicion of …

Melissa’s Story – Floxed Twice

I was floxed twice. The first time was in July of 2016 for a suspected UTI. There was no UTI. The bacterial culture came back negative, but no one ever called me to tell me to stop the antibiotics. I finished the entire prescribed dose of Cipro. Something was happening to me but I never …

Healing from Fluoroquinolone Toxicity Takes Time, Perseverance, Strength, and Kindness

Ruth wrote this as an update/guest post. You can read Ruth’s story of fluoroquinolone toxicity in “Ruth’s Story – Cipro Toxicity.” You can also listen to Ruth’s story through her episode of The Floxie Hope Podcast. Ruth has offered her insight and wisdom to thousands of “floxies” over the years. As of the publishing of this post, …

EMA Hearing on Fluoroquinolone Toxicity Part 3

In the first post about the EMA hearings (EMA Hearing on Fluoroquinolone Toxicity Part 1) I summarized the testimonials provided by Elizabeth Carmouche, Manex Bettan Arguinzoniz, Richard Cooknell, Markus Hamedinger, and Miriam Knight (who also spoke on behalf of Raymond Miller and Geoffrey Robinson), and in the second post about the EMA hearings (EMA Hearing on Fluoroquinolone Toxicity Part 2) …

EMA Hearing on Fluoroquinolone Toxicity Part 2

In the first post about the EMA hearings (EMA Hearing on Fluoroquinolone Toxicity Part 1) I summarized the testimonials provided by Elizabeth Carmouche, Manex Bettan Arguinzoniz, Richard Cooknell, Markus Hamedinger, and Miriam Knight (who also spoke on behalf of Raymond Miller and Geoffrey Robinson). In Part 2, and all subsequent posts about the EMA hearings, rather than summarizing my take …

EMA Hearing on Fluoroquinolone Toxicity Part 1

The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) held a hearing regarding the risks of permanent and disabling effects of fluoroquinolones (i.e. Fluoroquinolone Toxicity) on Wednesday June 13, 8018. More than 100 patient testimonials were submitted to the PRAC, and several dozen people who suffered from fluoroquinolone toxicity testified before the …

Rochelle’s Story – Recovery from Fluoroquinolone Toxicity

Rochelle’s story of fluoroquinolone toxicity and recovery.

Tony’s Story – Recovery from Cipro Toxicity

My name is Tony and here is my story. I have been “floxed” twice not knowing what “floxed” was until the second time. The first time was about 8 years ago. I was 20 years old and took Cipro for an infection. I had a bad reaction after finishing the prescription but never pin pointed …

Fluoroquinolone Toxicity Featured in NATURE

Fluoroquinolone toxicity is highlighted and featured in NATURE – one of the oldest, most reputable, journals in the world. This is so exciting!! You can read the article, When antibiotics turn toxic, that was published in Nature on March 21, 2018 HERE. Here are some highlights from the Nature article: First, thank you to Dr. Miriam van Staveren …

A Delicate Balance: Fluoroquinolones Disrupt Cellular Homeostasis

This post was inspired by, “My Father’s Body, at Rest and in Motion: His systems were failing. The challenge was to understand what had sustained them for so long.” by Siddhartha Mukherjee, published in the January 8, 2018 issue of The New Yorker. (When not noted otherwise, all quotes are from “My Father’s Body, at …

Toni’s Story of Recovery from Cipro Toxicity

I was a 56 year old mother of two, athletic runner and busy massage therapist until February 5, 2016 when my life changed forever. I went to a new dentist that fateful Friday afternoon and during a root canal was horribly injured and went straight from the maniacal dentist’s chair to ER to ICU for …

Hope for Floxies

This was originally sent to the people on the Floxie Hope Email List. If you would like posts like this sent to you, please sign up for the list HERE. Thank you!  I believe that hope is healing. I believe that seeing the possibility of healing and recovery are necessary for both healing and recovery. …

Fluoroquinolones and the Vagus Nerve

This was originally sent to the people on the Floxie Hope Email List. If you would like posts like this sent to you, please sign up for the list HERE. Thank you!  I was on Bulletproof Radio – It was amazing! Did you hear me on Bulletproof Radio with Dave Asprey? We chatted about fluoroquinolone …

Persistent Fluoroquinolones in the Body and Delayed Adverse Reactions

This is a guest post written by Gary. You can read Gary’s story HERE. It contains a wonderful wealth of knowledge, insight, and advice.  Fluoroquinolone side effects are often multisymptom affecting a wide range of bodily functions, ie: CNS, Muscles, Tendons, Brain, etc (Halkin, 1988l Mattappalil and Mergenhagen, 2014; Menzies et al., 1999; Moorthy et …